spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, T.
Right arrow Articles by Rubin, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, T.
Right arrow Articles by Rubin, G. M.

Development, Vol 117, Issue 4 1223-1237, Copyright © 1993 by Company of Biologists


JOURNAL ARTICLES

Analysis of genetic mosaics in developing and adult Drosophila tissues

T Xu and GM Rubin
Howard Hughes Medical Institute, University of California, Berkeley 94720.

We have constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila. Each of these strains carries an FRT element, the target for the yeast FLP recombinase, near the base of a major chromosome arm, as well as a gratuitous cell-autonomous marker. Novel markers that carry epitope tags and that are localized to either the cell nucleus or cell membrane have been generated. As a demonstration of how these strains can be used to study a particular gene, we have analyzed the developmental role of the Drosophila EGF receptor homolog. Moreover, we have shown that these strains can be utilized to identify new mutations in mosaic animals in an efficient and unbiased way, thereby providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.


This article has been cited by other articles:


Home page
J. Biol. Chem.Home page
D. S. Andersen and N. Tapon
Drosophila MFAP1 Is Required for Pre-mRNA Processing and G2/M Progression
J. Biol. Chem., November 7, 2008; 283(45): 31256 - 31267.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. Nusinow, L. Greenberg, and V. Hatini
Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium
Development, September 15, 2008; 135(18): 3031 - 3041.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. Strutt and S. J. Warrington
Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production
Development, September 15, 2008; 135(18): 3103 - 3111.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
D. Chen, J. Berger, M. Fellner, and T. Suzuki
FLYSNPdb: a high-density SNP database of Drosophila melanogaster
Nucleic Acids Res., September 10, 2008; (2008) gkn583v1.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
L. R. Braid and E. M. Verheyen
Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network
Genetics, September 1, 2008; 180(1): 283 - 299.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. del Alamo and M. Mlodzik
Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor
Development, September 1, 2008; 135(17): 2895 - 2904.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. Y. Park and M. Asano
The origin recognition complex is dispensable for endoreplication in Drosophila
PNAS, August 26, 2008; 105(34): 12343 - 12348.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
A. M. O'Reilly, H.-H. Lee, and M. A. Simon
Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary
J. Cell Biol., August 25, 2008; 182(4): 801 - 815.
[Abstract] [Full Text] [PDF]


Home page
DMMHome page
D. Nguyen and T. Xu
The expanding role of mouse genetics for understanding human biology and disease
Dis. Model. Mech., July 1, 2008; 1(1): 56 - 66.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
G. Lebreton, C. Faucher, D. L. Cribbs, and C. Benassayag
Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster
Development, July 1, 2008; 135(13): 2301 - 2309.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
W.-L. Chang, W. Liou, H.-C. Pen, H.-Y. Chou, Y.-W. Chang, W.-H. Li, W. Chiang, and L.-M. Pai
The gradient of Gurken, a long-range morphogen, is directly regulated by Cbl-mediated endocytosis
Development, June 1, 2008; 135(11): 1923 - 1933.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
X. Wu, M. Yamada-Mabuchi, E. J. Morris, P. S. Tanwar, L. Dobens, S. Gluderer, S. Khan, J. Cao, H. Stocker, E. Hafen, et al.
The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival
PNAS, April 8, 2008; 105(14): 5414 - 5419.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
K. L. Bates, M. Higley, and A. Letsou
Raw Mediates Antagonism of AP-1 Activity in Drosophila
Genetics, April 1, 2008; 178(4): 1989 - 2002.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
M. E. Kaplow, A. H. Korayem, and T. R. Venkatesh
Regulation of Glia Number in Drosophila by Rap/Fzr, an Activator of the Anaphase-Promoting Complex, and Loco, an RGS Protein
Genetics, April 1, 2008; 178(4): 2003 - 2016.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
R. I. Johnson, M. J. Seppa, and R. L. Cagan
The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning
J. Cell Biol., March 24, 2008; 180(6): 1191 - 1204.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. Sun, X. Wu, M. Han, T. Xu, and Y. Zhuang
A mitotic recombination system for mouse chromosome 17
PNAS, March 18, 2008; 105(11): 4237 - 4241.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Benchabane, E. G. Hughes, C. M. Takacs, J. R. Baird, and Y. Ahmed
Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
Development, March 1, 2008; 135(5): 963 - 971.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
L. Wang, Z. Li, and Y. Cai
The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche
J. Cell Biol., February 25, 2008; 180(4): 721 - 728.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C. Estella and R. S. Mann
Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg
Development, February 15, 2008; 135(4): 627 - 636.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A.-G. Tian and W.-M. Deng
Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
Development, February 1, 2008; 135(3): 463 - 471.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
T. Shimizu, L.-L. Ho, and Z.-C. Lai
The mob as tumor suppressor Gene Is Essential for Early Development and Regulates Tissue Growth in Drosophila
Genetics, February 1, 2008; 178(2): 957 - 965.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
N. Yakoby, J. Lembong, T. Schupbach, and S. Y. Shvartsman
Drosophila eggshell is patterned by sequential action of feedforward and feedback loops
Development, January 15, 2008; 135(2): 343 - 351.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
Z. Li, L. Wang, T. S. Hays, and Y. Cai
Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity
J. Cell Biol., January 10, 2008; 180(1): 31 - 38.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
D. K. Dickman, P. T. Kurshan, and T. L. Schwarz
Mutations in a Drosophila {alpha}2{delta} Voltage-Gated Calcium Channel Subunit Reveal a Crucial Synaptic Function
J. Neurosci., January 2, 2008; 28(1): 31 - 38.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
X. Zhou and L. M. Riddiford
rosy Function Is Required for Juvenile Hormone Effects in Drosophila melanogaster
Genetics, January 1, 2008; 178(1): 273 - 281.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
T. V. Lee, T. Ding, Z. Chen, V. Rajendran, H. Scherr, M. Lackey, C. Bolduc, and A. Bergmann
The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously
Development, January 1, 2008; 135(1): 43 - 52.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
B. Boettner and L. Van Aelst
The Rap GTPase Activator Drosophila PDZ-GEF Regulates Cell Shape in Epithelial Migration and Morphogenesis
Mol. Cell. Biol., November 15, 2007; 27(22): 7966 - 7980.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
H. T. Nguyen, F. Voza, N. Ezzeddine, and M. Frasch
Drosophila mind bomb2 is required for maintaining muscle integrity and survival
J. Cell Biol., October 22, 2007; 179(2): 219 - 227.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
K. J. T. Venken and H. J. Bellen
Transgenesis upgrades for Drosophila melanogaster
Development, October 15, 2007; 134(20): 3571 - 3584.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
G. B. Call, J. M. Olson, J. Chen, N. Villarasa, K. T. Ngo, A. M. Yabroff, S. Cokus, M. Pellegrini, E. Bibikova, C. Bui, et al.
Genomewide Clonal Analysis of Lethal Mutations in the Drosophila melanogaster Eye: Comparison of the X Chromosome and Autosomes
Genetics, October 1, 2007; 177(2): 689 - 697.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
N. Bogard, L. Lan, J. Xu, and R. S. Cohen
Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary
Development, October 1, 2007; 134(19): 3413 - 3418.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
R. Bastock and D. Strutt
The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
Development, September 1, 2007; 134(17): 3055 - 3064.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
S. Berger, N. A. Bulgakova, F. Grawe, K. Johnson, and E. Knust
Unraveling the Genetic Complexity of Drosophila stardust During Photoreceptor Morphogenesis and Prevention of Light-Induced Degeneration
Genetics, August 1, 2007; 176(4): 2189 - 2200.
[Abstract] [Full Text] [PDF]


Home page
CSH ProtocolsHome page
L. Luo
Single-Neuron Labeling Using the Genetic MARCM Method
CSH Protocols, July 1, 2007; 2007(14): pdb.prot4789 - pdb.prot4789.
[Abstract] [Full Text]


Home page
DevelopmentHome page
B. V. Shravage, G. Altmann, M. Technau, and S. Roth
The role of Dpp and its inhibitors during eggshell patterning in Drosophila
Development, June 15, 2007; 134(12): 2261 - 2271.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
Y. A. Zeng, M. Rahnama, S. Wang, W. Sosu-Sedzorme, and E. M. Verheyen
Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation
Development, June 1, 2007; 134(11): 2061 - 2071.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
S. Chung, S. Kim, J. Yoon, P. N. Adler, and J. Yim
The Balance Between the Novel Protein Target of Wingless and the Drosophila Rho-Associated Kinase Pathway Regulates Planar Cell Polarity in the Drosophila Wing
Genetics, June 1, 2007; 176(2): 891 - 903.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
J. Xie, S. L. Bessling, T. K. Cooper, H. C. Dietz, A. S. McCallion, and S. Fisher
Manipulating Mitotic Recombination in the Zebrafish Embryo Through RecQ Helicases
Genetics, June 1, 2007; 176(2): 1339 - 1342.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J. B. Cordero, D. E. Larson, C. R. Craig, R. Hays, and R. Cagan
Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina
Development, May 15, 2007; 134(10): 1861 - 1871.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. P. Bruinsma, R. L. Cagan, and T. J. Baranski
Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye
PNAS, April 24, 2007; 104(17): 7098 - 7103.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
D. Pan
Hippo signaling in organ size control
Genes & Dev., April 15, 2007; 21(8): 886 - 897.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
M. Grammont
Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
J. Cell Biol., April 9, 2007; 177(1): 139 - 150.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Lee, B. G. Stultz, and D. A. Hursh
The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development
Development, April 1, 2007; 134(7): 1301 - 1310.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
T. Sasamura, H. O. Ishikawa, N. Sasaki, S. Higashi, M. Kanai, S. Nakao, T. Ayukawa, T. Aigaki, K. Noda, E. Miyoshi, et al.
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila
Development, April 1, 2007; 134(7): 1347 - 1356.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Letizia, R. Barrio, and S. Campuzano
Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning
Development, April 1, 2007; 134(7): 1337 - 1346.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
S. Lee and L. Cooley
Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis
J. Cell Biol., March 26, 2007; 176(7): 941 - 952.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
E. Assa-Kunik, I. L. Torres, E. D. Schejter, D. S. Johnston, and B.-Z. Shilo
Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways
Development, March 15, 2007; 134(6): 1161 - 1169.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. D. Muzumdar, L. Luo, and H. Zong
From the Cover: Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)
PNAS, March 13, 2007; 104(11): 4495 - 4500.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
W. Wang, M. Warren, and A. Bradley
From the Cover: Induced mitotic recombination of p53 in vivo
PNAS, March 13, 2007; 104(11): 4501 - 4505.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
D. M. Tyler, W. Li, N. Zhuo, B. Pellock, and N. E. Baker
Genes Affecting Cell Competition in Drosophila
Genetics, February 1, 2007; 175(2): 643 - 657.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
A. Garg, A. Srivastava, M. M. Davis, S. L. O'Keefe, L. Chow, and J. B. Bell
Antagonizing Scalloped With a Novel Vestigial Construct Reveals an Important Role for Scalloped in Drosophila melanogaster Leg, Eye and Optic Lobe Development
Genetics, February 1, 2007; 175(2): 659 - 669.
[Abstract] [Full Text] [PDF]


Home page
GENES CELLSHome page
N. Sasaki, T. Sasamura, H. O. Ishikawa, M. Kanai, R. Ueda, K. Saigo, and K. Matsuno
Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells.
Genes Cells, January 1, 2007; 12(1): 89 - 103.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
M. Sese, M. Corominas, H. Stocker, T. I. Heino, E. Hafen, and F. Serras
The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye
J. Cell Sci., December 15, 2006; 119(24): 5047 - 5056.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
R. M. Goodman, S. Thombre, Z. Firtina, D. Gray, D. Betts, J. Roebuck, E. P. Spana, and E. M. Selva
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
Development, December 15, 2006; 133(24): 4901 - 4911.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Singh, X. Shi, and K.-W. Choi
Lobe and Serrate are required for cell survival during early eye development in Drosophila.
Development, December 1, 2006; 133(23): 4771 - 4781.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
L. A. Ekas, G.-H. Baeg, M. S. Flaherty, A. Ayala-Camargo, and E. A. Bach
JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
Development, December 1, 2006; 133(23): 4721 - 4729.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
F. A. Martin and G. Morata
Compartments and the control of growth in the Drosophila wing imaginal disc
Development, November 15, 2006; 133(22): 4421 - 4426.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
L. F. de Navas, D. L. Garaulet, and E. Sanchez-Herrero
The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway
Development, November 15, 2006; 133(22): 4495 - 4506.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
C. Molnar, A. Lopez-Varea, R. Hernandez, and J. F. de Celis
A Gain-of-Function Screen Identifying Genes Required for Vein Formation in the Drosophila melanogaster Wing
Genetics, November 1, 2006; 174(3): 1635 - 1659.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
V. Mirouse, E. Formstecher, and J.-L. Couderc
Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila
Development, October 15, 2006; 133(20): 4005 - 4013.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
T. E. Rusten, L. M.W. Rodahl, K. Pattni, C. Englund, C. Samakovlis, S. Dove, A. Brech, and H. Stenmark
Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Controls Trafficking but Not Silencing of Endocytosed Receptors
Mol. Biol. Cell, September 1, 2006; 17(9): 3989 - 4001.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C. Laplante and L. A. Nilson
Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila
Development, August 15, 2006; 133(16): 3255 - 3264.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Herranz, G. Morata, and M. Milan
calderon encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues
Development, July 15, 2006; 133(14): 2617 - 2625.
[Abstract] [Full Text] [PDF]