|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 117, Issue 4 1345-1353, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
CF Ibanez, P Ernfors, T Timmusk, NY Ip, E Arenas, GD Yancopoulos and H Persson
Department of Medical Chemistry II, Karolinska Institute, Stockholm, Sweden.
The cellular localization of mRNA for neurotrophin-4 (NT-4), a novel neurotrophic factor, in the developing whisker follicles and skin of the embryonic rat is demonstrated by in situ hybridization. Levels of NT-4 mRNA in the whisker pad decrease between embryonic day 13 (E13) and E20, correlating in time with the onset of naturally occurring neuronal death in the innervating trigeminal ganglion. In addition to NT-4, brain-derived neuotrophic factor (BDNF) mRNA is also shown to be expressed in the rat embryonic whisker follicles although in a different cellular localization, which combined with previous data on the expression of NGF and NT-3 mRNAs, shows that all four neurotrophins are expressed during development of this structure. NT-4 protein is shown to elicit neurite outgrowth from explanted embryonic trigeminal ganglia and to promote neuronal survival of dissociated trigeminal ganglion neurons when cultured during the phase of cell death. NT-4 and NT-3 mainly support different neuronal subpopulations, whereas some NT-4-responsive cells appear to respond also to NGF and BDNF. Analysis of mRNAs for members of the Trk family of neurotrophin receptors in neurons rescued by different neurotrophins demonstrates the presence of distinct neuronal subpopulations that respond to specific combinations of these factors. Based on these results we propose that NT-4, together with the other three neurotrophins, orchestrate the innervation of the different structures of the developing whisker pad by the trigeminal ganglion, acting as target-derived neurotrophic factors for different subpopulations of trigeminal ganglion neurons.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Grigaliunas, R. M. Bradley, D. K. MacCallum, and C. M. Mistretta Distinctive Neurophysiological Properties of Embryonic Trigeminal and Geniculate Neurons in Culture J Neurophysiol, October 1, 2002; 88(4): 2058 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Fox, R. J. Phillips, E. A. Baronowsky, M. S. Byerly, S. Jones, and T. L. Powley Neurotrophin-4 Deficient Mice Have a Loss of Vagal Intraganglionic Mechanoreceptors from the Small Intestine and a Disruption of Short-Term Satiety J. Neurosci., November 1, 2001; 21(21): 8602 - 8615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Baudet, A Mikaels, H Westphal, J Johansen, T. Johansen, and P Ernfors Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins Development, January 10, 2000; 127(20): 4335 - 4344. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Fried, C. Nosrat, C. Lillesaar, and C. Hildebrand Molecular Signaling and Pulpal Nerve Development Critical Reviews in Oral Biology & Medicine, January 1, 2000; 11(3): 318 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Bennett, S. R. Zeiler, and K. R. Jones Patterned Expression of BDNF and NT-3 in the Retina and Anterior Segment of the Developing Mammalian Eye Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2996 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. BOTCHKAREV, N. V. BOTCHKAREVA, P. WELKER, M. METZ, G. R. LEWIN, A. SUBRAMANIAM, S. BULFONE-PAUS, E. HAGEN, A. BRAUN, M. LOMMATZSCH, et al. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control FASEB J, February 1, 1999; 13(2): 395 - 410. [Abstract] [Full Text]
|
|
|
|
|
|
C. L. Stucky, T. DeChiara, R. M. Lindsay, G. D. Yancopoulos, and M. Koltzenburg Neurotrophin 4 Is Required for the Survival of a Subclass of Hair Follicle Receptors J. Neurosci., September 1, 1998; 18(17): 7040 - 7046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nosrat, J Blomlof, W. ElShamy, P Ernfors, and L Olson Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively Development, January 4, 1997; 124(7): 1333 - 1342. [Abstract] [PDF]
|
|
|
|
|
|
J. T. Erickson, J. C. Conover, V. Borday, J. Champagnat, M. Barbacid, G. Yancopoulos, and D. M. Katz Mice Lacking Brain-Derived Neurotrophic Factor Exhibit Visceral Sensory Neuron Losses Distinct from Mice Lacking NT4 and Display a Severe Developmental Deficit in Control of Breathing J. Neurosci., September 1, 1996; 16(17): 5361 - 5371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo Development, January 2, 1996; 122(2): 715 - 724. [Abstract] [PDF]
|
|
|
|
 |
|
 H Funakoshi, N Belluardo, E Arenas, Y Yamamoto, A Casabona, H Persson, and C. Ibanez Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons Science, June 9, 1995; 268(5216): 1495 - 1499. [Abstract] [PDF]
|
|
