|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 117, Issue 4 1409-1420, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
R Moore and FS Walsh
Department of Experimental Pathology, UMDS, Guy's Hospital, London, UK.
The spatiotemporal distribution of M-cadherin mRNA has been determined by in situ hybridization in the mouse embryo and in adult skeletal muscle following experimental regeneration and denervation. M-cadherin mRNA is highly tissue specific and is found only in developing skeletal muscle. In contrast, N-cadherin mRNA has a broader tissue distribution in the embryo, being found on both neural elements and skeletal and cardiac muscle. M-cadherin is expressed in the myotomes shortly after they form, along with the myogenic regulatory factor myogenin. M-cadherin is expressed in muscles derived from the myotomes and is detected in forelimb bud precursor cells at embryonic day 11.5. In the latter case M-cadherin expression appears co-ordinately with that of myogenin and cardiac alpha-actin. Shortly before birth, M-cadherin expression is down regulated. M-cadherin can, however, be re-expressed following experimental regeneration of skeletal muscle. Here M-cadherin is transiently expressed on regenerating myoblasts but not myotubes. Following muscle denervation no evidence was found for re-expression of M-cadherin under conditions where there was strong expression of the nicotinic acetylcholine receptor on myofibres. The highly specific tissue distribution and unique developmental profile distinguishes M-cadherin from other cadherins and suggests a role in cell surface events during early myogenesis.
This article has been cited by other articles:
|
|
 |
|
  K. Rouger, B. Fornasari, V. Armengol, G. Jouvion, I. Leroux, L. Dubreil, M. Feron, L. Guevel, and Y. Cherel Progenitor Cell Isolation From Muscle-derived Cells Based on Adhesion Properties J. Histochem. Cytochem., June 1, 2007; 55(6): 607 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Charrasse, F. Comunale, M. Fortier, E. Portales-Casamar, A. Debant, and C. Gauthier-Rouviere M-Cadherin Activates Rac1 GTPase through the Rho-GEF Trio during Myoblast Fusion Mol. Biol. Cell, May 1, 2007; 18(5): 1734 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charrasse, F. Comunale, Y. Grumbach, F. Poulat, A. Blangy, and C. Gauthier-Rouviere RhoA GTPase Regulates M-Cadherin Activity and Myoblast Fusion Mol. Biol. Cell, February 1, 2006; 17(2): 749 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Doherty, A. Cave, D. B. Davis, A. J. Delmonte, A. Posey, J. U. Earley, M. Hadhazy, and E. M. McNally Normal myoblast fusion requires myoferlin Development, December 15, 2005; 132(24): 5565 - 5575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Krauss, F. Cole, U. Gaio, G. Takaesu, W. Zhang, and J.-S. Kang Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact J. Cell Sci., June 1, 2005; 118(11): 2355 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maier and A. Bornemann M-cadherin transcription in satellite cells from normal and denervated muscle Am J Physiol Cell Physiol, March 1, 2004; 286(3): C708 - C712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. P. CHARGE and M. A. RUDNICKI Cellular and Molecular Regulation of Muscle Regeneration Physiol Rev, January 1, 2004; 84(1): 209 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Kang, J. L. Feinleib, S. Knox, M. A. Ketteringham, and R. S. Krauss Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation PNAS, April 1, 2003; 100(7): 3989 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hollnagel, C. Grund, W. W. Franke, and H.-H. Arnold The Cell Adhesion Molecule M-Cadherin Is Not Essential for Muscle Development and Regeneration Mol. Cell. Biol., July 1, 2002; 22(13): 4760 - 4770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Beauchamp, L. Heslop, D. S.W. Yu, S. Tajbakhsh, R. G. Kelly, A. Wernig, M. E. Buckingham, T. A. Partridge, and P. S. Zammit Expression of CD34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells J. Cell Biol., December 11, 2000; 151(6): 1221 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kuschel, Z. Yablonka–Reuveni, and A. Bornemann Satellite Cells on Isolated Myofibers from Normal and Denervated Adult Rat Muscle J. Histochem. Cytochem., November 1, 1999; 47(11): 1375 - 1384. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Lu, L KASer, and M MUNtener Experimental changes to limb muscles elicit contralateral reactions: the problem of controls J. Exp. Biol., January 6, 1999; 202(12): 1691 - 1700. [Abstract]
|
|
|
|
|
|
M Zeschnigk, D Kozian, C Kuch, M Schmoll, and A Starzinski-Powitz Involvement of M-cadherin in terminal differentiation of skeletal muscle cells J. Cell Sci., January 9, 1995; 108(9): 2973 - 2981. [Abstract] [PDF]
|
|
|
|
|
|
A Paululat, S Burchard, and R Renkawitz-Pohl Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila Development, January 8, 1995; 121(8): 2611 - 2620. [Abstract] [PDF]
|
|
