Development, Vol 118, Issue 2 401-415, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

AH Brand and N Perrimon
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.

We have designed a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns. The gene encoding the yeast transcriptional activator GAL4 is inserted randomly into the Drosophila genome to drive GAL4 expression from one of a diverse array of genomic enhancers. It is then possible to introduce a gene containing GAL4 binding sites within its promoter, to activate it in those cells where GAL4 is expressed, and to observe the effect of this directed misexpression on development. We have used GAL4-directed transcription to expand the domain of embryonic expression of the homeobox protein even-skipped. We show that even-skipped represses wingless and transforms cells that would normally secrete naked cuticle into denticle secreting cells. The GAL4 system can thus be used to study regulatory interactions during embryonic development. In adults, targeted expression can be used to generate dominant phenotypes for use in genetic screens. We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway.
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				H. Deng, S. C. Hughes, J. B. Bell, and A. J. Simmonds Alternative Requirements for Vestigial, Scalloped, and Dmef2 during Muscle Differentiation in Drosophila melanogaster Mol. Biol. Cell, January 1, 2009; 20(1): 256 - 269. [Abstract] [Full Text] [PDF]

				J. Yun, J. H. Cao, M. W. Dodson, I. E. Clark, P. Kapahi, R. B. Chowdhury, and M. Guo Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not an Essential Component of the pink1/parkin Pathway In Vivo J. Neurosci., December 31, 2008; 28(53): 14500 - 14510. [Abstract] [Full Text] [PDF]

				K. Kirby, L. T. Jensen, J. Binnington, A. J. Hilliker, J. Ulloa, V. C. Culotta, and J. P. Phillips Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone J. Biol. Chem., December 19, 2008; 283(51): 35393 - 35401. [Abstract] [Full Text] [PDF]

				Y. Shang, L. C. Griffith, and M. Rosbash From the Cover: Feature Article: Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain PNAS, December 16, 2008; 105(50): 19587 - 19594. [Abstract] [Full Text] [PDF]