spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bodmer, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bodmer, R.

Development, Vol 118, Issue 3 719-729, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

R Bodmer
Department of Biology, University of Michigan, Ann Arbor 48109-1048.

The homeobox-containing gene tinman (msh-2, Bodmer et al., 1990 Development 110, 661-669) is expressed in the mesoderm primordium, and this expression requires the function of the mesoderm determinant twist. Later in development, as the first mesodermal subdivisions are occurring, expression becomes limited to the visceral mesoderm and the heart. Here, I show that the function of tinman is required for visceral muscle and heart development. Embryos that are mutant for the tinman gene lack the appearance of visceral mesoderm and of heart primordia, and the fusion of the anterior and posterior endoderm is impaired. Even though tinman mutant embryos do not have a heart or visceral muscles, many of the somatic body wall muscles appear to develop although abnormally. When the tinman cDNA is ubiquitously expressed in tinman mutant embryos, via a heatshock promoter, formation of heart cells and visceral mesoderm is partially restored, tinman seems to be one of the earliest genes required for heart development and the first gene reported for which a crucial function in the early mesodermal subdivisions has been implicated.


This article has been cited by other articles:


Home page
 Circ. Res.Home page
L. E. Briggs, M. Takeda, A. E. Cuadra, H. Wakimoto, M. H. Marks, A. J. Walker, T. Seki, S. P. Oh, J. T. Lu, C. Sumners, et al.
Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects
Circ. Res., September 12, 2008; 103(6): 580 - 590.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wang, H. Zhang, D. Iyer, X.-H. Feng, and R. J. Schwartz
Regulation of Cardiac Specific nkx2.5 Gene Activity by Small Ubiquitin-like Modifier
J. Biol. Chem., August 22, 2008; 283(34): 23235 - 23243.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Nagao, Y. Taniyama, T. Kietzmann, T. Doi, I. Komuro, and R. Morishita
HIF-1{alpha} Signaling Upstream of NKX2.5 Is Required for Cardiac Development in Xenopus
J. Biol. Chem., April 25, 2008; 283(17): 11841 - 11849.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Zmojdzian, J. P. Da Ponte, and K. Jagla
Cellular components and signals required for the cardiac outflow tract assembly in Drosophila
PNAS, February 19, 2008; 105(7): 2475 - 2480.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. F. van Loo, E. A. F. Mahtab, L. J. Wisse, J. Hou, F. Grosveld, G. Suske, S. Philipsen, and A. C. Gittenberger-de Groot
Transcription Factor Sp3 Knockout Mice Display Serious Cardiac Malformations
Mol. Cell. Biol., December 15, 2007; 27(24): 8571 - 8582.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Duan, C. Zhang, J. Chen, H. Sink, E. Frei, and M. Noll
A key role of Pox meso in somatic myogenesis of Drosophila
Development, November 15, 2007; 134(22): 3985 - 3997.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. S. Jakobsen, M. Braun, J. Astorga, E. H. Gustafson, T. Sandmann, M. Karzynski, P. Carlsson, and E. E.M. Furlong
Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network
Genes & Dev., October 1, 2007; 21(19): 2448 - 2460.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Karamboulas, A. Swedani, C. Ward, A. S. Al-Madhoun, S. Wilton, S. Boisvenue, A. G. Ridgeway, and I. S. Skerjanc
HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage
J. Cell Sci., October 15, 2006; 119(20): 4305 - 4314.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Zaffran, I. Reim, L. Qian, P. C. Lo, R. Bodmer, and M. Frasch
Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila
Development, October 15, 2006; 133(20): 4073 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
Y. Satou and N. Satoh
Gene regulatory networks for the development and evolution of the chordate heart
Genes & Dev., October 1, 2006; 20(19): 2634 - 2638.
[Full Text] [PDF]

Home page
 ScienceHome page
E. N. Olson
Gene regulatory networks in the evolution and development of the heart.
Science, September 29, 2006; 313(5795): 1922 - 1927.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Akasaka, S. Klinedinst, K. Ocorr, E. L. Bustamante, S. K. Kim, and R. Bodmer
The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
PNAS, August 8, 2006; 103(32): 11999 - 12004.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. A. Elliott, M. J. Solloway, N. Wise, C. Biben, M. W. Costa, M. B. Furtado, M. Lange, S. Dunwoodie, and R. P. Harvey
A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery
Development, April 1, 2006; 133(7): 1311 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Han, P. Yi, X. Li, and E. N. Olson
Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis
Development, March 15, 2006; 133(6): 1175 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. C. Serluca and M. C. Fishman
Big, bad hearts: From flies to man.
PNAS, March 14, 2006; 103(11): 3947 - 3948.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
V. Salvador-Recatala, W. J. Gallin, J. Abbruzzese, P. C. Ruben, and A. N. Spencer
A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit
J. Exp. Biol., February 15, 2006; 209(4): 731 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Wolf, H. Amrein, J. A. Izatt, M. A. Choma, M. C. Reedy, and H. A. Rockman
From The Cover: Drosophila as a model for the identification of genes causing adult human heart disease
PNAS, January 31, 2006; 103(5): 1394 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Reim and M. Frasch
The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila
Development, November 15, 2005; 132(22): 4911 - 4925.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Chi, P. K. Chatterjee, W. Wilson III, S.-X. Zhang, F. J. DeMayo, and R. J. Schwartz
Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules
PNAS, September 20, 2005; 102(38): 13490 - 13495.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Han and E. N. Olson
Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis
Development, August 1, 2005; 132(15): 3525 - 3536.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. A. Epstein and M. S. Parmacek
Recent Advances in Cardiac Development With Therapeutic Implications for Adult Cardiovascular Disease
Circulation, July 26, 2005; 112(4): 592 - 597.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Wang, Y. Tao, I. Reim, K. Gajewski, M. Frasch, and R. A. Schulz
Expression, Regulation, and Requirement of the Toll Transmembrane Protein during Dorsal Vessel Formation in Drosophila melanogaster
Mol. Cell. Biol., May 15, 2005; 25(10): 4200 - 4210.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H.-H. Lee and M. Frasch
Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction
Development, March 15, 2005; 132(6): 1429 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. S. Balakirev and F. J. Ayala
Nucleotide Variation in the tinman and bagpipe Homeobox Genes of Drosophila melanogaster
Genetics, April 1, 2004; 166(4): 1845 - 1856.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J.-A. Mas, E. Garcia-Zaragoza, and M. Cervera
Two Functionally Identical Modular Enhancers in Drosophila Troponin T Gene Establish the Correct Protein Levels in Different Muscle Types
Mol. Biol. Cell, April 1, 2004; 15(4): 1931 - 1945.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Stathopoulos, B. Tam, M. Ronshaugen, M. Frasch, and M. Levine
pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos
Genes & Dev., March 15, 2004; 18(6): 687 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M.-C. Marin, J.-R. Rodriguez, and A. Ferrus
Transcription of Drosophila Troponin I Gene Is Regulated by Two Conserved, Functionally Identical, Synergistic Elements
Mol. Biol. Cell, March 1, 2004; 15(3): 1185 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. J. Gruber and J. A. Epstein
Development Gone Awry: Congenital Heart Disease
Circ. Res., February 20, 2004; 94(3): 273 - 283.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Stute, K. Schimmelpfeng, R. Renkawitz-Pohl, R. H. Palmer, and A. Holz
Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(miliAlk) as receptor for Jeb signalling
Development, February 15, 2004; 131(4): 743 - 754.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Ueyama, H. Kasahara, T. Ishiwata, Q. Nie, and S. Izumo
Myocardin Expression Is Regulated by Nkx2.5, and Its Function Is Required for Cardiomyogenesis
Mol. Cell. Biol., December 15, 2003; 23(24): 9222 - 9232.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. B. McElhinney, E. Geiger, J. Blinder, D. Woodrow Benson, and E. Goldmuntz
NKX2.5 mutations in patients with congenital heart disease
J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1650 - 1655.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. Dell'Era, R. Ronca, L. Coco, S. Nicoli, M. Metra, and M. Presta
Fibroblast Growth Factor Receptor-1 Is Essential for In Vitro Cardiomyocyte Development
Circ. Res., September 5, 2003; 93(5): 414 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ueyama, H. Kasahara, T. Ishiwata, N. Yamasaki, and S. Izumo
Csm, a Cardiac-specific Isoform of the RNA Helicase Mov10l1, Is Regulated by Nkx2.5 in Embryonic Heart
J. Biol. Chem., August 1, 2003; 278(31): 28750 - 28757.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Reim, H.-H. Lee, and M. Frasch
The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp
Development, July 15, 2003; 130(14): 3187 - 3204.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. L. Klinedinst and R. Bodmer
Gata factor Pannier is required to establish competence for heart progenitor formation
Development, July 1, 2003; 130(13): 3027 - 3038.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Han and R. Bodmer
Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division
Development, July 1, 2003; 130(13): 3039 - 3051.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Ganga, H. M. Espinoza, C. J. Cox, L. Morton, T. A. Hjalt, Y. Lee, and B. A. Amendt
PITX2 Isoform-specific Regulation of Atrial Natriuretic Factor Expression: SYNERGISM AND REPRESSION WITH Nkx2.5
J. Biol. Chem., June 13, 2003; 278(25): 22437 - 22445.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Sachinidis, B. K. Fleischmann, E. Kolossov, M. Wartenberg, H. Sauer, and J. Hescheler
Cardiac specific differentiation of mouse embryonic stem cells
Cardiovasc Res, May 1, 2003; 58(2): 278 - 291.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Hosono, K. Takaira, R. Matsuda, and K. Saigo
Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development
Development, February 1, 2003; 130(3): 439 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Zhang, T. A. Yatskievych, X. Cao, and P. B. Antin
Regulation of Hex Gene Expression by a Smads-dependent Signaling Pathway
J. Biol. Chem., November 15, 2002; 277(47): 45435 - 45441.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L.-H. Wang, R. Chmelik, and M. Nirenberg
Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila
PNAS, October 1, 2002; 99(20): 12721 - 12726.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Zaffran and M. Frasch
Early Signals in Cardiac Development
Circ. Res., September 20, 2002; 91(6): 457 - 469.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Sepulveda, S. Vlahopoulos, D. Iyer, N. Belaguli, and R. J. Schwartz
Combinatorial Expression of GATA4, Nkx2-5, and Serum Response Factor Directs Early Cardiac Gene Activity
J. Biol. Chem., July 5, 2002; 277(28): 25775 - 25782.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Q. Gong and L. Li
Dermo-1, a Multifunctional Basic Helix-Loop-Helix Protein, Represses MyoD Transactivation via the HLH Domain, MEF2 Interaction, and Chromatin Deacetylation
J. Biol. Chem., March 29, 2002; 277(14): 12310 - 12317.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. Thisse and L. I. Zon
Organogenesis--Heart and Blood Formation from the Zebrafish Point of View
Science, January 18, 2002; 295(5554): 457 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
S. ZAFFRAN, X. XU, P.C.H. LO, H.-H. LEE, and M. FRASCH
Cardiogenesis in the Drosophila Model: Control Mechanisms during Early Induction and Diversification of Cardiac Progenitors
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 1 - 12.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
M. TANAKA, C.I. BERUL, M. ISHII, P.Y. JAY, H. WAKIMOTO, P. DOUGLAS, N. YAMASAKI, T. KAWAMOTO, J. GEHRMANN, C.T. MAGUIRE, et al.
A Mouse Model of Congenital Heart Disease: Cardiac Arrhythmias and Atrial Septal Defect Caused by Haploinsufficiency of the Cardiac Transcription Factor Csx/Nkx2.5
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 317 - 326.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc
Nkx2-5 Activity Is Essential for Cardiomyogenesis
J. Biol. Chem., November 2, 2001; 276(45): 42252 - 42258.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. Zaffran, A. Kuchler, H.-H. Lee, and M. Frasch
biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila
Genes & Dev., November 1, 2001; 15(21): 2900 - 2915.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Castanon, S. Von Stetina, J. Kass, and M. K. Baylies
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
Development, August 15, 2001; 128(16): 3145 - 3159.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. Banerjee-Basu and A. D. Baxevanis
Molecular evolution of the homeodomain family of transcription factors
Nucleic Acids Res., August 1, 2001; 29(15): 3258 - 3269.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Tanaka, M. Schinke, H.-S. Liao, N. Yamasaki, and S. Izumo
Nkx2.5 and Nkx2.6, Homologs of Drosophila tinman, Are Required for Development of the Pharynx
Mol. Cell. Biol., July 1, 2001; 21(13): 4391 - 4398.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Redkar, M. Montgomery, and J. Litvin
Fate map of early avian cardiac progenitor cells
Development, June 15, 2001; 128(12): 2269 - 2279.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. J. Marvin, G. Di Rocco, A. Gardiner, S. M. Bush, and A. B. Lassar
Inhibition of Wnt activity induces heart formation from posterior mesoderm
Genes & Dev., February 1, 2001; 15(3): 316 - 327.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
S. Hayes, J. Miller, and D. Hoshizaki
serpent, a GATA-like transcription factor gene, induces fat-cell development in Drosophila melanogaster
Development, January 4, 2001; 128(7): 1193 - 1200.
[Abstract] [PDF]

Home page
 Circ. Res.Home page
J. A. Epstein
Developmental Cardiology Comes of Age
Circ. Res., November 10, 2000; 87(10): 833 - 834.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. S. Belaguli, J. L. Sepulveda, V. Nigam, F. Charron, M. Nemer, and R. J. Schwartz
Cardiac Tissue Enriched Factors Serum Response Factor and GATA-4 Are Mutual Coregulators
Mol. Cell. Biol., October 15, 2000; 20(20): 7550 - 7558.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Fossett, Q. Zhang, K. Gajewski, C. Y. Choi, Y. Kim, and R. A. Schulz
The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo
PNAS, June 20, 2000; 97(13): 7348 - 7353.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Tanaka, N. Yamasaki, and S. Izumo
Phenotypic Characterization of the Murine Nkx2.6 Homeobox Gene by Gene Targeting
Mol. Cell. Biol., April 15, 2000; 20(8): 2874 - 2879.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
E. Ward and J. Skeath
Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo
Development, January 11, 2000; 127(22): 4959 - 4969.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Zaffran and M Frasch
Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity
Development, January 3, 2000; 127(5): 1115 - 1130.
[Abstract] [PDF]

Home page
 DevelopmentHome page
F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand
Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)
Development, January 1, 2000; 127(2): 225 - 235.
[Abstract] [PDF]

Home page
 ScienceHome page
K. P. White, S. A. Rifkin, P. Hurban, and D. S. Hogness
Microarray Analysis of Drosophila Development During Metamorphosis
Science, December 10, 1999; 286(5447): 2179 - 2184.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. Y. Choi, Y. M. Lee, Y. H. Kim, T. Park, B. H. Jeon, R. A. Schulz, and Y. Kim
The Homeodomain Transcription Factor NK-4 Acts as either a Transcriptional Activator or Repressor and Interacts with the p300 Coactivator and the Groucho Corepressor
J. Biol. Chem.,