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Development, Vol 118, Issue 3 719-729, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
R Bodmer
Department of Biology, University of Michigan, Ann Arbor 48109-1048.
The homeobox-containing gene tinman (msh-2, Bodmer et al., 1990 Development 110, 661-669) is expressed in the mesoderm primordium, and this expression requires the function of the mesoderm determinant twist. Later in development, as the first mesodermal subdivisions are occurring, expression becomes limited to the visceral mesoderm and the heart. Here, I show that the function of tinman is required for visceral muscle and heart development. Embryos that are mutant for the tinman gene lack the appearance of visceral mesoderm and of heart primordia, and the fusion of the anterior and posterior endoderm is impaired. Even though tinman mutant embryos do not have a heart or visceral muscles, many of the somatic body wall muscles appear to develop although abnormally. When the tinman cDNA is ubiquitously expressed in tinman mutant embryos, via a heatshock promoter, formation of heart cells and visceral mesoderm is partially restored, tinman seems to be one of the earliest genes required for heart development and the first gene reported for which a crucial function in the early mesodermal subdivisions has been implicated.
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M Tanaka, Z Chen, S Bartunkova, N Yamasaki, and S Izumo The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development Development, January 3, 1999; 126(6): 1269 - 1280. [Abstract] [PDF]
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H. Kasahara and S. Izumo Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5 Mol. Cell. Biol., January 1, 1999; 19(1): 526 - 536. [Abstract] [Full Text] [PDF]
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C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development, January 1, 1999; 126(1): 75 - 84. [Abstract] [PDF]
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I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910. [Abstract] [Full Text] [PDF]
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A. Carmena, S. Gisselbrecht, J. Harrison, F. Jiménez, and A. M. Michelson Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm Genes & Dev., December 15, 1998; 12(24): 3910 - 3922. [Abstract] [Full Text]
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J. B. Weiss, T. Von Ohlen, D. M. Mellerick, G. Dressler, C. Q. Doe, and M. P. Scott Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity Genes & Dev., November 15, 1998; 12(22): 3591 - 3602. [Abstract] [Full Text]
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G. F. Wang, W. Nikovits Jr., M. Schleinitz, and F. E. Stockdale A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis Mol. Cell. Biol., October 1, 1998; 18(10): 6023 - 6034. [Abstract] [Full Text]
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M. Park, C. Lewis, D. Turbay, A. Chung, J.-N. Chen, S. Evans, R. E. Breitbart, M. C. Fishman, S. Izumo, and R. Bodmer Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes PNAS, August 4, 1998; 95(16): 9366 - 9371. [Abstract] [Full Text] [PDF]
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J. Schott, D. W. Benson, C. T. Basson, W. Pease, G. M. Silberbach, J. P. Moak, B. J. Maron, C. E. Seidman, and J. G. Seidman Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5 Science, July 3, 1998; 281(5373): 108 - 111. [Abstract] [Full Text]
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Y. Lee, T. Shioi, H. Kasahara, S. M. Jobe, R. J. Wiese, B. E. Markham, and S. Izumo The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression Mol. Cell. Biol., June 1, 1998; 18(6): 3120 - 3129. [Abstract] [Full Text]
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J. L. Sepulveda, N. Belaguli, V. Nigam, C.-Y. Chen, M. Nemer, and R. J. Schwartz GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression Mol. Cell. Biol., June 1, 1998; 18(6): 3405 - 3415. [Abstract] [Full Text]
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H. Kasahara, S. Bartunkova, M. Schinke, M. Tanaka, and S. Izumo Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein Circ. Res., May 19, 1998; 82(9): 936 - 946. [Abstract] [Full Text] [PDF]
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 J. T. Thompson, M. S. Rackley, and T. X. O'Brien Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1569 - H1573. [Abstract] [Full Text] [PDF]
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C. Haun, J. Alexander, D. Y. Stainier, and P. G. Okkema Rescue of Caenorhabditis elegans pharyngeal development by a vertebrate heart specification gene PNAS, April 28, 1998; 95(9): 5072 - 5075. [Abstract] [Full Text] [PDF]
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Y Fu, W Yan, T. Mohun, and S. Evans Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner Development, January 11, 1998; 125(22): 4439 - 4449. [Abstract] [PDF]
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R. Searcy, E. Vincent, C. Liberatore, and K. Yutzey A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice Development, January 11, 1998; 125(22): 4461 - 4470. [Abstract] [PDF]
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G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice Development, January 8, 1998; 125(16): 3037 - 3048. [Abstract] [PDF]
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L. Moore, H. Broihier, M Van Doren, and R Lehmann Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila Development, January 3, 1998; 125(5): 837 - 844. [Abstract] [PDF]
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