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Development, Vol 118, Issue 3 719-729, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

R Bodmer
Department of Biology, University of Michigan, Ann Arbor 48109-1048.

The homeobox-containing gene tinman (msh-2, Bodmer et al., 1990 Development 110, 661-669) is expressed in the mesoderm primordium, and this expression requires the function of the mesoderm determinant twist. Later in development, as the first mesodermal subdivisions are occurring, expression becomes limited to the visceral mesoderm and the heart. Here, I show that the function of tinman is required for visceral muscle and heart development. Embryos that are mutant for the tinman gene lack the appearance of visceral mesoderm and of heart primordia, and the fusion of the anterior and posterior endoderm is impaired. Even though tinman mutant embryos do not have a heart or visceral muscles, many of the somatic body wall muscles appear to develop although abnormally. When the tinman cDNA is ubiquitously expressed in tinman mutant embryos, via a heatshock promoter, formation of heart cells and visceral mesoderm is partially restored, tinman seems to be one of the earliest genes required for heart development and the first gene reported for which a crucial function in the early mesodermal subdivisions has been implicated.
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F. Fremion, M. Astier, S. Zaffran, A. Guillen, V. Homburger, and M. Semeriva
The Heterotrimeric Protein Go Is Required for the Formation of Heart Epithelium in Drosophila
J. Cell Biol., May 31, 1999; 145(5): 1063 - 1076.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
I. Shiojima, I. Komuro, T. Oka, Y. Hiroi, T. Mizuno, E. Takimoto, K. Monzen, R. Aikawa, H. Akazawa, T. Yamazaki, et al.
Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4
J. Biol. Chem., March 19, 1999; 274(12): 8231 - 8239.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
K Gajewski, N Fossett, J. Molkentin, and R. Schulz
The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
Development, January 12, 1999; 126(24): 5679 - 5688.
[Abstract] [PDF]

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 DevelopmentHome page
M Fujioka, Y Emi-Sarker, G. Yusibova, T Goto, and J. Jaynes
Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
Development, January 6, 1999; 126(11): 2527 - 2538.
[Abstract] [PDF]

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 DevelopmentHome page
M. Su, M Fujioka, T Goto, and R Bodmer
The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision
Development, January 6, 1999; 126(14): 3241 - 3251.
[Abstract] [PDF]

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 DevelopmentHome page
M Tanaka, S. Wechsler, I. Lee, N Yamasaki, J. Lawitts, and S Izumo
Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
Development, January 4, 1999; 126(7): 1439 - 1450.
[Abstract] [PDF]

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 DevelopmentHome page
M Tanaka, Z Chen, S Bartunkova, N Yamasaki, and S Izumo
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
Development, January 3, 1999; 126(6): 1269 - 1280.
[Abstract] [PDF]

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 Mol. Cell. Biol.Home page
H. Kasahara and S. Izumo
Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5
Mol. Cell. Biol., January 1, 1999; 19(1): 526 - 536.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
Development, January 1, 1999; 126(1): 75 - 84.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton
Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells
J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
A. Carmena, S. Gisselbrecht, J. Harrison, F. Jiménez, and A. M. Michelson
Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm
Genes & Dev., December 15, 1998; 12(24): 3910 - 3922.
[Abstract] [Full Text]

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 Genes Dev.Home page
J. B. Weiss, T. Von Ohlen, D. M. Mellerick, G. Dressler, C. Q. Doe, and M. P. Scott
Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity
Genes & Dev., November 15, 1998; 12(22): 3591 - 3602.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
G. F. Wang, W. Nikovits Jr., M. Schleinitz, and F. E. Stockdale
A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis
Mol. Cell. Biol., October 1, 1998; 18(10): 6023 - 6034.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
M. Park, C. Lewis, D. Turbay, A. Chung, J.-N. Chen, S. Evans, R. E. Breitbart, M. C. Fishman, S. Izumo, and R. Bodmer
Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
PNAS, August 4, 1998; 95(16): 9366 - 9371.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
J. Schott, D. W. Benson, C. T. Basson, W. Pease, G. M. Silberbach, J. P. Moak, B. J. Maron, C. E. Seidman, and J. G. Seidman
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
Science, July 3, 1998; 281(5373): 108 - 111.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
Y. Lee, T. Shioi, H. Kasahara, S. M. Jobe, R. J. Wiese, B. E. Markham, and S. Izumo
The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression
Mol. Cell. Biol., June 1, 1998; 18(6): 3120 - 3129.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
J. L. Sepulveda, N. Belaguli, V. Nigam, C.-Y. Chen, M. Nemer, and R. J. Schwartz
GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression
Mol. Cell. Biol., June 1, 1998; 18(6): 3405 - 3415.
[Abstract] [Full Text]

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 Circ. Res.Home page
H. Kasahara, S. Bartunkova, M. Schinke, M. Tanaka, and S. Izumo
Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein
Circ. Res., May 19, 1998; 82(9): 936 - 946.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
J. T. Thompson, M. S. Rackley, and T. X. O'Brien
Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload
Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1569 - H1573.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. Haun, J. Alexander, D. Y. Stainier, and P. G. Okkema
Rescue of Caenorhabditis elegans pharyngeal development by a vertebrate heart specification gene
PNAS, April 28, 1998; 95(9): 5072 - 5075.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
Y Fu, W Yan, T. Mohun, and S. Evans
Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner
Development, January 11, 1998; 125(22): 4439 - 4449.
[Abstract] [PDF]

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 DevelopmentHome page
R. Searcy, E. Vincent, C. Liberatore, and K. Yutzey
A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice
Development, January 11, 1998; 125(22): 4461 - 4470.
[Abstract] [PDF]

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 DevelopmentHome page
G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson
Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice
Development, January 8, 1998; 125(16): 3037 - 3048.
[Abstract] [PDF]

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 DevelopmentHome page
L. Moore, H. Broihier, M Van Doren, and R Lehmann
Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila
Development, January 3, 1998; 125(5): 837 - 844.
[Abstract] [PDF]


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