|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 118, Issue 3 777-784, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
HS Coles, JF Burne and MC Raff
Department of Biology, University College London, UK.
Although normal cell death is known to occur in many developing vertebrate organs, it has not been thought to play an important part in the development of the mammalian kidney. We show here that normal cell death is found in both the nephrogenic region and medullary papilla of the developing rat kidney and, in each of these areas, it follows a distinct developmental time course. As many as 3% of the cells in these areas have a typical apoptotic morphology and the dead cells seem to be cleared rapidly (within 1-2 hours) by phagocytosis by neighbouring parenchymal cells. These values are similar to those in vertebrate neural tissues where 50% or more of the cells die during normal development, suggesting that large-scale death is a normal feature of kidney development. We also show that in vivo treatment with epidermal growth factor inhibits cell death in the developing kidney, consistent with the possibility that the cells normally die because they lack sufficient survival factors. Our findings suggest that the extent of normal cell death in developing animals is still greatly underestimated and they raise the possibility that many of these cell deaths may reflect limiting amounts of survival factors.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Ishibe, A. Karihaloo, H. Ma, J. Zhang, A. Marlier, M. Mitobe, A. Togawa, R. Schmitt, J. Czyczk, M. Kashgarian, et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology Development, January 15, 2009; 136(2): 337 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Saisho, E. Manesso, T. Gurlo, C.-j. Huang, G. M. Toffolo, C. Cobelli, and P. C. Butler Development of factors to convert frequency to rate for {beta}-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E89 - E96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Willing and A. G. Van Kessel Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig J Anim Sci, December 1, 2007; 85(12): 3256 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-K. Song, W.-Y. Kim, H.-W. Lee, E.-Y. Park, K.-H. Han, S. Nielsen, K. M. Madsen, and J. Kim Origin and Fate of Pendrin-Positive Intercalated Cells in Developing Mouse Kidney J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2672 - 2682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Singh, L. A. Cullen-McEwen, M. M. Kett, W.-M. Boon, J. Dowling, J. F. Bertram, and K. M. Moritz Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring J. Physiol., March 1, 2007; 579(2): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Petri, J. Ahnfelt-Ronne, K. S. Frederiksen, D. G. Edwards, D. Madsen, P. Serup, J. Fleckner, and R S. Heller The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J. Mol. Endocrinol., October 1, 2006; 37(2): 301 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kipari, J.-F. Cailhier, D. Ferenbach, S. Watson, K. Houlberg, D. Walbaum, S. Clay, J. Savill, and J. Hughes Nitric Oxide Is an Important Mediator of Renal Tubular Epithelial Cell Death in Vitro and in Murine Experimental Hydronephrosis Am. J. Pathol., August 1, 2006; 169(2): 388 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F.M Maree, R. Kublik, D. T Finegood, and L. Edelstein-Keshet Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Phil Trans R Soc A, May 15, 2006; 364(1842): 1267 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grieshammer, C. Cebrian, R. Ilagan, E. Meyers, D. Herzlinger, and G. R. Martin FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons Development, September 1, 2005; 132(17): 3847 - 3857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. M. Welham, P. R. Riley, A. Wade, M. Hubank, and A. S. Woolf Maternal diet programs embryonic kidney gene expression Physiol Genomics, June 16, 2005; 22(1): 48 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yamate, Y. Machida, M. Ide, M. Kuwamura, T. Kotani, O. Sawamoto, and J. LaMarre Cisplatin-Induced Renal Interstitial Fibrosis in Neonatal Rats, Developing as Solitary Nephron Unit Lesions Toxicol Pathol, February 1, 2005; 33(2): 207 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sato, K. Harada, K. Kizawa, T. Sanzen, S. Furubo, M. Yasoshima, S. Ozaki, M. Ishibashi, and Y. Nakanuma Activation of the MEK5/ERK5 Cascade Is Responsible for Biliary Dysgenesis in a Rat Model of Caroli's Disease Am. J. Pathol., January 1, 2005; 166(1): 49 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kultz Hypertonicity and TonEBP promote development of the renal concentrating system Am J Physiol Renal Physiol, November 1, 2004; 287(5): F876 - F877. [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Davies, M. Ladomery, P. Hohenstein, L. Michael, A. Shafe, L. Spraggon, and N. Hastie Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation Hum. Mol. Genet., January 15, 2004; 13(2): 235 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, J.-K. Chen, S.-w. Wang, G. Moeckel, and R. C. Harris Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic Injury J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3147 - 3154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dziarmaga, P. Clark, C. Stayner, J. P. Julien, E. Torban, P. Goodyer, and M. Eccles Ureteric Bud Apoptosis and Renal Hypoplasia in Transgenic PAX2-Bax Fetal Mice Mimics the Renal-Coloboma Syndrome J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2767 - 2774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Pham, N. K. MacLennan, C. T. Chiu, G. S. Laksana, J. L. Hsu, and R. H. Lane Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R962 - R970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Paris, C. Bernard-Kargar, M.-F. Berthault, L. Bouwens, and A. Ktorza Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic {beta}-Cell Mass in Vivo in Adult Rats Endocrinology, June 1, 2003; 144(6): 2717 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Bonventre Dedifferentiation and Proliferation of Surviving Epithelial Cells in Acute Renal Failure J. Am. Soc. Nephrol., June 1, 2003; 14(90001): S55 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Whitehead, K. A. Earle, J. Fetter, S. Xu, T. Hartman, D. C. Chan, T. L. M. Zhao, G. Piazza, A. J.P. Klein-Szanto, R. Pamukcu, et al. Exisulind-induced Apoptosis in a Non-Small Cell Lung Cancer Orthotopic Lung Tumor Model Augments Docetaxel Treatment and Contributes to Increased Survival Mol. Cancer Ther., May 1, 2003; 2(5): 479 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Thiruchelvam, P. Nyirady, D. M. Peebles, C. H. Fry, P. M. Cuckow, and A. S. Woolf Urinary Outflow Obstruction Increases Apoptosis and Deregulates Bcl-2 and Bax Expression in the Fetal Ovine Bladder Am. J. Pathol., April 1, 2003; 162(4): 1271 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hurbin, L. Dubrez, J.-L. Coll, and M.-C. Favrot Inhibition of Apoptosis by Amphiregulin via an Insulin-like Growth Factor-1 Receptor-dependent Pathway in Non-small Cell Lung Cancer Cell Lines J. Biol. Chem., December 13, 2002; 277(51): 49127 - 49133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bouchard, A. Souabni, M. Mandler, A. Neubuser, and M. Busslinger Nephric lineage specification by Pax2 and Pax8 Genes & Dev., November 15, 2002; 16(22): 2958 - 2970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Bottinger and M. Bitzer TGF-{beta} Signaling in Renal Disease J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2600 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kondo, A. Sekizawa, H. Saito, M. Jimbo, Y. Sugito, and T. Okai Fate of Fetal Nucleated Erythrocytes Circulating in Maternal Blood: Apoptosis Is Induced by Maternal Oxygen Concentration Clin. Chem., September 1, 2002; 48(9): 1618 - 1620. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Stuart and J. Hughes Apoptosis and autoimmunity Nephrol. Dial. Transplant., May 1, 2002; 17(5): 697 - 700. [Full Text] [PDF]
|
|
|
|
|
|
J. P. M. Barbera, T. A. Rodriguez, N. D. E. Greene, W. J. Weninger, A. Simeone, A. J. Copp, R. S. P. Beddington, and S. Dunwoodie Folic acid prevents exencephaly in Cited2 deficient mice Hum. Mol. Genet., February 1, 2002; 11(3): 283 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Fisher, L. Michael, M. W. Barnett, and J. A. Davies Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney Development, November 1, 2001; 128(21): 4329 - 4338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Burns and A. B. Hassan Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation Development, October 1, 2001; 128(19): 3819 - 3830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. CHA, Y.-H. KIM, J.-Y. JUNG, K.-H. HAN, K. M. MADSEN, and J. KIM Cell Proliferation in the Loop of Henle in the Developing Rat Kidney J. Am. Soc. Nephrol., July 1, 2001; 12(7): 1410 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-D. WAGNER, N. WAGNER, V. P. SUKHATME, and H. SCHOLZ Activation of Vitamin D Receptor by the Wilms' Tumor GeneProduct Mediates Apoptosis of Renal Cells J. Am. Soc. Nephrol., June 1, 2001; 12(6): 1188 - 1196. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. T. Finegood, M. D. McArthur, D. Kojwang, M. J. Thomas, B. G. Topp, T. Leonard, and R. E. Buckingham {beta}-Cell Mass Dynamics in Zucker Diabetic Fatty Rats: Rosiglitazone Prevents the Rise in Net Cell Death Diabetes, May 1, 2001; 50(5): 1021 - 1029. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Ozaki, M. Ishizaki, M. Ghazizadeh, and N. Yamanaka Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea Br J Ophthalmol, May 1, 2001; 85(5): 613 - 618. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Murray and D. Edgar Regulation of Programmed Cell Death by Basement Membranes in Embryonic Development J. Cell Biol., September 4, 2000; 150(5): 1215 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Torban, M. R. Eccles, J. Favor, and P. R. Goodyer PAX2 Suppresses Apoptosis in Renal Collecting Duct Cells Am. J. Pathol., September 1, 2000; 157(3): 833 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Raatikainen–Ahokas, T. M. Immonen, P. O. Rossi, K. M.H. Sainio, and H. V. Sariola An Artifactual In Situ Hybridization Signal Associated with Apoptosis in Rat Embryo J. Histochem. Cytochem., July 1, 2000; 48(7): 955 - 962. [Abstract] [Full Text]
|
|
|
|
|
|
S. NATHANSON, E. MOREAU, C. MERLET-BENICHOU, and T. GILBERT In Utero and in Vitro Exposure to {beta}-Lactams Impair Kidney Development in the Rat J. Am. Soc. Nephrol., May 1, 2000; 11(5): 874 - 884. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. El Mouedden, G. Laurent, M.-P. Mingeot-Leclercq, H. S. Taper, J. Cumps, and P. M. Tulkens Apoptosis in Renal Proximal Tubules of Rats Treated with Low Doses of Aminoglycosides Antimicrob. Agents Chemother., March 1, 2000; 44(3): 665 - 675. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Marchi, W. Liu, and V. C. Broaddus Mesothelial cell apoptosis is confirmed in vivo by morphological change in cytokeratin distribution Am J Physiol Lung Cell Mol Physiol, March 1, 2000; 278(3): L528 - L535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Bouchard, P Pfeffer, and M Busslinger Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development Development, January 9, 2000; 127(17): 3703 - 3713. [Abstract] [PDF]
|
|
|
|
|
|
J. Hughes, P. Brown, and S. J. Shankland Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction Am J Physiol Renal Physiol, December 1, 1999; 277(6): F948 - F956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. BERNARD, M.-F. BERTHAULT, C. SAULNIER, and A. KTORZA Neogenesis vs. apoptosis as main components of pancreatic ß cell mass changes in glucose-infused normal and mildly diabetic adult rats FASEB J, July 1, 1999; 13(10): 1195 - 1205. [Abstract] [Full Text]
|
|
|
|
|
|
J. Hughes and R. J. Johnson Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction Am J Physiol Renal Physiol, July 1, 1999; 277(1): F26 - F32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. DiFederico, O. Genbacev, and S. J. Fisher Preeclampsia Is Associated with Widespread Apoptosis of Placental Cytotrophoblasts within the Uterine Wall Am. J. Pathol., July 1, 1999; 155(1): 293 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Bruce, C. E. Honaker, and R. J. Cross Lung Fibroblasts Undergo Apoptosis Following Alveolarization Am. J. Respir. Cell Mol. Biol., February 1, 1999; 20(2): 228 - 236. [Abstract] [Full Text]
|
|
|
|
|
|
A. Moore, L McInnes, J Kreidberg, N. Hastie, and A Schedl YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis Development, January 5, 1999; 126(9): 1845 - 1857. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Kurosaka, N. Watanabe, and Y. Kobayashi Production of Proinflammatory Cytokines by Phorbol Myristate Acetate-Treated THP-1 Cells and Monocyte-Derived Macrophages After Phagocytosis of Apoptotic CTLL-2 Cells J. Immunol., December 1, 1998; 161(11): 6245 - 6249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Smith, E. Price, M. J. Hewitt, E. M. Symonds, and P. N. Baker Cellular Proliferation in the Placenta in Normal Human Pregnancy and Pregnancy Complicated by Intrauterine Growth Restriction Reproductive Sciences, November 1, 1998; 5(6): 317 - 323. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Davis and D. H. Ryan Review Article: Apoptosis in the Kidney Toxicol Pathol, November 1, 1998; 26(6): 810 - 825. [Abstract] [PDF]
|
|
|
|
 |
|
 S. C. Smith Comment on Apoptosis and Fas Expression in Human Fetal Membranesi J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3761a - 3761. [Full Text]
|
|
|
|
 |
|
 H Ikeda, Y Suzuki, M Suzuki, M Koike, J Tamura, J Tong, M Nomura, and G Itoh Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium Gut, April 1, 1998; 42(4): 530 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Noda, R. Iwakiri, K. Fujimoto, S. Matsuo, and T. Y. Aw Programmed cell death induced by ischemia-reperfusion in rat intestinal mucosa Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G270 - G276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Godin, N. Takaesu, E. Robertson, and A. Dudley Regulation of BMP7 expression during kidney development Development, January 9, 1998; 125(17): 3473 - 3482. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Scavo, R. Ertsey, C. J. Chapin, L. Allen, and J. A. Kitterman Apoptosis in the Development of Rat and Human Fetal Lungs Am. J. Respir. Cell Mol. Biol., January 1, 1998; 18(1): 21 - 31. [Abstract] [Full Text]
|
|
|
|
|
|
T. Takemura, S. Kondo, T. Homma, M. Sakai, and R. C. Harris The Membrane-bound Form of Heparin-binding Epidermal Growth Factor-like Growth Factor Promotes Survival of Cultured Renal Epithelial Cells J. Biol. Chem., December 5, 1997; 272(49): 31036 - 31042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trudel, J. Lanoix, L. Barisoni, M.-J. Blouin, M. Desforges, C. L'Italien, and V. D'Agati C-MYC-induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent J. Exp. Med., December 1, 1997; 186(11): 1873 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barasch, J. Qiao, G. McWilliams, D. Chen, J. A. Oliver, and D. Herzlinger Ureteric bud cells secrete multiple factors, including bFGF, which rescue renal progenitors from apoptosis Am J Physiol Renal Physiol, November 1, 1997; 273(5): F757 - F767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moser, A. Pscherer, C. Roth, J. Becker, G. Mucher, K. Zerres, C. Dixkens, J. Weis, L. Guay-Woodford, R. Buettner, et al. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta Genes & Dev., August 1, 1997; 11(15): 1938 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Scaglia, C. J. Cahill, D. T. Finegood, and S. Bonner-Weir Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat Endocrinology, April 1, 1997; 138(4): 1736 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Miyamoto, M Yoshida, S Kuratani, I Matsuo, and S Aizawa Defects of urogenital development in mice lacking Emx2 Development, January 5, 1997; 124(9): 1653 - 1664. [Abstract] [PDF]
|
|
|
|
 |
|
 M. C.G. Horrigan, A. I. MacIsaac, F. A. Nicolini, D. G. Vince, P. Lee, S. G. Ellis, and E. J. Topol Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model Circulation, October 15, 1996; 94(8): 1927 - 1933. [Abstract] [Full Text]
|
|
|
|
|
|
R. Humphreys, M Krajewska, S Krnacik, R Jaeger, H Weiher, S Krajewski, J. Reed, and J. Rosen Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis Development, January 12, 1996; 122(12): 4013 - 4022. [Abstract] [PDF]
|
|
|
|
|
|
J. Wu and E. Adamson Kinase-negative mutant epidermal growth factor receptor (EGFR) expression during embryonal stem cell differentiation favours EGFR-independent lineages Development, January 10, 1996; 122(10): 3331 - 3342. [Abstract] [PDF]
|
|
|
|
|
|
A Vaahtokari, T Aberg, and I Thesleff Apoptosis in the developing tooth: association with an embryonic signaling center and suppression by EGF and FGF-4 Development, January 1, 1996; 122(1): 121 - 129. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Patapoutian, B. J. Wold, and R. A. Wagner Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle Science, December 15, 1995; 270(5243): 1818 - 1821. [Abstract] [PDF]
|
|
|
|
|
|
A T Dudley, K M Lyons, and E J Robertson A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes & Dev., November 15, 1995; 9(22): 2795 - 2807. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Woo Apoptosis and Loss of Renal Tissue in Polycystic Kidney Diseases N. Engl. J. Med., July 6, 1995; 333(1): 18 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Saelman, P. Keely, and S. Santoro Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis J. Cell Sci., January 11, 1995; 108(11): 3531 - 3540. [Abstract] [PDF]
|
|
|
|
|
|
S Kumar, M Kinoshita, M Noda, N G Copeland, and N A Jenkins Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes & Dev., July 15, 1994; 8(14): 1613 - 1626. [Abstract] [PDF]
|
|
|
|
|
|
P. Hall, P. Coates, B Ansari, and D Hopwood Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis J. Cell Sci., January 12, 1994; 107(12): 3569 - 3577. [Abstract] [PDF]
|
|
|
|
|
|
M. Raff, B. Barres, J. Burne, H. Coles, Y Ishizaki, and M. Jacobson Programmed cell death and the control of cell survival: lessons from the nervous system Science, October 29, 1993; 262(5134): 695 - 700. [Abstract] [PDF]
|
|
|
|
|
|
M. Goldberg, C. Peshkovsky, A. Shifteh, and Q. Al-Awqati {micro}-Protocadherin, a Novel Developmentally Regulated Protocadherin with Mucin-like Domains J. Biol. Chem., August 4, 2000; 275(32): 24622 - 24629. [Abstract] [Full Text] [PDF]
|
|
