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Development, Vol 118, Issue 3 817-827, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
C Kelley, H Blumberg, LI Zon and T Evans
Children's Hospital, Harvard Medical School, Boston, MA 02115.
We have isolated and characterized Xenopus cDNA clones for a new transcription factor that represents an early marker for the developing heart. The cDNAs encode a protein that we have designated GATA-4; it contains the highly conserved DNA-binding domain that characterizes this family of cell-type restricted transcriptional activators. Whole-embryo in situ analysis of Xenopus embryos demonstrates that the GATA-4 gene is transcribed in presumptive cardiac ventral mesoderm at the time that bilateral progenitors fuse and form the cardiac tube. GATA-4 is therefore the earliest molecular marker of cardiogenesis yet characterized. By stage 30, the GATA-4 mRNA is expressed in the developing atria and ventricles; at stage 38, cross-sections reveal that the gene is active in the endocardial layer, but not in myocardium. By stage 40, GATA-4 message is detected in the great vessels. In the adult frog, the GATA-4 gene is highly transcribed in heart and gut; lower levels of message are detected in various endoderm-derived tissues and gonads. Expression in the stomach is largely confined to the epithelium. The GATA-4 gene is first activated at stage 11; mRNA is initially present throughout the marginal zone of explants and later partially localized to the ventral marginal zone. GATA-4 mRNA is also detected at high levels in cultured endodermal explants derived from the vegetal region of early embryos. In mesoderm induction experiments, GATA-4 transcription is not induced in animal caps treated with activin or bFGF. The GATA-4 gene may provide a new early marker for studying the inductive processes that lead to the formation of the cardiovascular system and for the specification of the endocardial lineage.
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|
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|
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|
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|
|
|
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|
|
|
 |
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|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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A. S. Perkins and J. H. Kim Zinc Fingers 1-7 of EVI1 Fail to Bind to the GATA Motif by Itself but Require the Core Site GACAAGATA for Binding J. Biol. Chem., January 12, 1996; 271(2): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
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|
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|
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|
|
|
|
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Y Wei, D Bader, and J Litvin Identification of a novel cardiac-specific transcript critical for cardiac myocyte differentiation Development, January 9, 1996; 122(9): 2779 - 2789. [Abstract] [PDF]
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W.-H. Lin, L.-H. Huang, J.-Y. Yeh, Jör. Hoheisel, H. Lehrach, Y. H. Sun, and S.-F. Tsai Expression of a Drosophila GATA Transcription Factor in Multiple Tissues in the Developing Embryos J. Biol. Chem., October 20, 1995; 270(42): 25150 - 25158. [Abstract] [Full Text] [PDF]
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V. Lacronique, S. Lopez, L. Miquerol, A. Porteu, A. Kahn, and M. Raymondjean Identification and Functional Characterization of an Erythroid-specific Enhancer in the L-type Pyruvate Kinase Gene J. Biol. Chem., June 23, 1995; 270(25): 14989 - 14997. [Abstract] [Full Text] [PDF]
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