|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 118, Issue 4 1169-1180, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
WE Theurkauf, BM Alberts, YN Jan and TA Jongens
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
Drosophila oocytes develop within cysts containing 16 cells that are interconnected by cytoplasmic bridges. Although the cysts are syncytial, the 16 cells differentiate to form a single oocyte and 15 nurse cells, and several mRNAs that are synthesized in the nurse cells accumulate specifically in the oocyte. To gain insight into the mechanisms that generate the cytoplasmic asymmetry within these cysts, we have examined cytoskeletal organization during oocyte differentiation. Shortly after formation of the 16 cell cysts, a prominent microtubule organizing center (MTOC) is established within the syncytial cytoplasm, and at the time the oocyte is determined, a single microtubule cytoskeleton connects the oocyte with the remaining 15 cells of each cyst. Recessive mutations at the Bicaudal-D (Bic-D) and egalitarian (egl) loci, which block oocyte differentiation, disrupt formation and maintenance of this polarized microtubule cytoskeleton. Microtubule assembly-inhibitors phenocopy these mutations, and prevent oocyte-specific accumulation of oskar, cyclin B and 65F mRNAs. We propose that formation of the polarized microtubule cytoskeleton is required for oocyte differentiation, and that this structure mediates the asymmetric accumulation of mRNAs within the syncytial cysts.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Roth and J. A. Lynch Symmetry Breaking During Drosophila Oogenesis Cold Spring Harb Perspect Biol, August 1, 2009; 1(2): a001891 - a001891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Navarro, S. Bullock, and R. Lehmann Altered dynein-dependent transport in piRNA pathway mutants PNAS, June 16, 2009; 106(24): 9691 - 9696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gervais, S. Claret, J. Januschke, S. Roth, and A. Guichet PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte Development, December 1, 2008; 135(23): 3829 - 3838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mische, M. Li, M. Serr, and T. S. Hays Direct Observation of Regulated Ribonucleoprotein Transport Across the Nurse Cell/Oocyte Boundary Mol. Biol. Cell, June 1, 2007; 18(6): 2254 - 2263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clark, C. Meignin, and I. Davis A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte Development, May 15, 2007; 134(10): 1955 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Coutelis and A. Ephrussi Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis Development, April 1, 2007; 134(7): 1419 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Moorhead, K. A. Rzomp, and M. A. Scidmore The Rab6 Effector Bicaudal D1 Associates with Chlamydia trachomatis Inclusions in a Biovar-Specific Manner Infect. Immun., February 1, 2007; 75(2): 781 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mirouse, E. Formstecher, and J.-L. Couderc Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila Development, October 15, 2006; 133(20): 4005 - 4013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Cox and A. C. Spradling Milton controls the early acquisition of mitochondria by Drosophila oocytes Development, September 1, 2006; 133(17): 3371 - 3377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.E. THEURKAUF, C. KLATTENHOFF, D.P. BRATU, N. McGINNIS-SCHULTZ, B.S. KOPPETSCH, and H.A. COOK rasiRNAs, DNA Damage, and Embryonic Axis Specification Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 171 - 180. [Abstract] [PDF]
|
|
|
|
|
|
J. Januschke, L. Gervais, L. Gillet, G. Keryer, M. Bornens, and A. Guichet The centrosome-nucleus complex and microtubule organization in the Drosophila oocyte Development, January 1, 2006; 133(1): 129 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Snee, E. A. Arn, S. L. Bullock, and P. M. Macdonald Recognition of the bcd mRNA Localization Signal in Drosophila Embryos and Ovaries Mol. Cell. Biol., February 15, 2005; 25(4): 1501 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. d. C. Seleme, O. Disson, S.ép. Robin, C. Brun, D. Teninges, and A. Bucheton In vivo RNA localization of I factor, a non-LTR retrotransposon, requires a cis-acting signal in ORF2 and ORF1 protein Nucleic Acids Res., February 1, 2005; 33(2): 776 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Manandhar, H. Schatten, and P. Sutovsky Centrosome Reduction During Gametogenesis and Its Significance Biol Reprod, January 1, 2005; 72(1): 2 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Snapp, T. Iida, D. Frescas, J. Lippincott-Schwartz, and M. A. Lilly The Fusome Mediates Intercellular Endoplasmic Reticulum Connectivity in Drosophila Ovarian Cysts Mol. Biol. Cell, October 1, 2004; 15(10): 4512 - 4521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iida and M. A. Lilly missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila Development, March 1, 2004; 131(5): 1029 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Wilhelm, M. Hilton, Q. Amos, and W. J. Henzel Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz J. Cell Biol., December 22, 2003; 163(6): 1197 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Tavosanis and C. Gonzalez {gamma}-Tubulin function during female germ-cell development and oogenesis in Drosophila PNAS, September 2, 2003; 100(18): 10263 - 10268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Z. Morris, C. Navarro, and R. Lehmann Identification and Analysis of Mutations in bob, Doa and Eight New Genes Required for Oocyte Specification and Development in Drosophila melanogaster Genetics, August 1, 2003; 164(4): 1435 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Cox and A. C. Spradling A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis Development, April 15, 2003; 130(8): 1579 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hong, S. Lee-Kong, T. Iida, I. Sugimura, and M. A. Lilly The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I Development, April 1, 2003; 130(7): 1235 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, W. Lu, T. Obara, S. Kuida, J. Lehoczky, K. Dewar, I. A. Drummond, and D. R. Beier A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish Development, March 14, 2003; 129(24): 5839 - 5846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mathe, Y. H. Inoue, W. Palframan, G. Brown, and D. M. Glover Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis Development, March 1, 2003; 130(5): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Holland, A. Milne, K. Garka, R. S. Johnson, C. Willis, J. E. Sims, C. T. Rauch, T. A. Bird, and G. D. Virca Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2 J. Biol. Chem., May 3, 2002; 277(18): 16229 - 16240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Minestrini, E. Mathe, and D. M. Glover Domains of the Pavarotti kinesin-like protein that direct its subcellular distribution: effects of mislocalisation on the tubulin and actin cytoskeleton during Drosophila oogenesis J. Cell Sci., February 15, 2002; 115(4): 725 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Cox, S. A. Seyfried, L. Y. Jan, and Y. N. Jan Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary PNAS, December 4, 2001; 98(25): 14475 - 14480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Mohr, S. T. Dillon, and R. E. Boswell The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis Genes & Dev., November 1, 2001; 15(21): 2886 - 2899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Battaglia, S. Zito, A. Macchini, and F. Gigliani A Drosophila model of HIV-Tat-related pathogenicity J. Cell Sci., January 8, 2001; 114(15): 2787 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Bolvar, J. Huynh, H Lpez-Schier, C Gonzlez, D St Johnston, and A Gonzlez-Reyes Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton Development, January 5, 2001; 128(10): 1889 - 1897. [Abstract] [PDF]
|
|
|
|
|
|
J. Huynh, J. Shulman, R Benton, and D St Johnston PAR-1 is required for the maintenance of oocyte fate in Drosophila Development, January 4, 2001; 128(7): 1201 - 1209. [Abstract] [PDF]
|
|
|
|
|
|
K. Munn and R. Steward The shut-down Gene of Drosophila melanogaster Encodes a Novel FK506-Binding Protein Essential for the Formation of Germline Cysts During Oogenesis Genetics, September 1, 2000; 156(1): 245 - 256. [Abstract] [Full Text]
|
|
|
|
|
|
O. Wessely and E. M. De Robertis The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation Development, May 15, 2000; 127(10): 2053 - 2062. [Abstract] [PDF]
|
|
|
|
|
|
J. Oh, K. Baksa, and R. Steward Functional Domains of the Drosophila Bicaudal-D Protein Genetics, February 1, 2000; 154(2): 713 - 724. [Abstract] [Full Text]
|
|
|
|
|
|
N. Grieder, M de Cuevas, and A. Spradling The fusome organizes the microtubule network during oocyte differentiation in Drosophila Development, January 10, 2000; 127(19): 4253 - 4264. [Abstract] [PDF]
|
|
|
|
|
|
J Huynh and D St Johnston The role of BicD, egl, orb and the microtubules in the restriction of meiosis to the Drosophila oocyte Development, January 7, 2000; 127(13): 2785 - 2794. [Abstract] [PDF]
|
|
|
|
|
|
C Pare and B Suter Subcellular localization of Bic-D::GFP is linked to an asymmetric oocyte nucleus J. Cell Sci., January 6, 2000; 113(12): 2119 - 2127. [Abstract] [PDF]
|
|
|
|
|
|
F Peri and S Roth Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg Development, January 2, 2000; 127(4): 841 - 850. [Abstract] [PDF]
|
|
|
|
|
|
A. Kasravi, M. F. Walter, S. Brand, J. M. Mason, and H. Biessmann Molecular Cloning and Tissue-Specific Expression of the mutator2 Gene (mu2) in Drosophila melanogaster Genetics, July 1, 1999; 152(3): 1025 - 1035. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. LASKO RNA sorting in Drosophila oocytes and embryos FASEB J, March 1, 1999; 13(3): 421 - 433. [Abstract] [Full Text]
|
|
|
|
|
|
Z Liu, T Xie, and R Steward Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation Development, January 10, 1999; 126(20): 4477 - 4488. [Abstract] [PDF]
|
|
|
|
|
|
S. Bergsten and E. Gavis Role for mRNA localization in translational activation but not spatial restriction of nanos RNA Development, January 2, 1999; 126(4): 659 - 669. [Abstract] [PDF]
|
|
|
|
|
|
V. A. Lantz and K. G. Miller A Class VI Unconventional Myosin Is Associated with a Homologue of a Microtubule-binding Protein, Cytoplasmic Linker Protein-170, in Neurons and at the Posterior Pole of Drosophila Embryos J. Cell Biol., February 23, 1998; 140(4): 897 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Gonzalez, G Tavosanis, and C Mollinari Centrosomes and microtubule organisation during Drosophila development J. Cell Sci., January 9, 1998; 111(18): 2697 - 2706. [Abstract] [PDF]
|
|
|
|
|
|
W. Theurkauf and T. Hazelrigg In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: characterization of a multi-step anterior localization pathway Development, January 9, 1998; 125(18): 3655 - 3666. [Abstract] [PDF]
|
|
|
|
|
|
S Reinsch and P Gonczy Mechanisms of nuclear positioning J. Cell Sci., January 8, 1998; 111(16): 2283 - 2295. [Abstract] [PDF]
|
|
|
|
|
|
M de Cuevas and A. Spradling Morphogenesis of the Drosophila fusome and its implications for oocyte specification Development, January 8, 1998; 125(15): 2781 - 2789. [Abstract] [PDF]
|
|
|
|
|
|
J M Mach and R Lehmann An Egalitarian-BicaudalD complex is essential for oocyte specification and axis determination in Drosophila. Genes & Dev., February 15, 1997; 11(4): 423 - 435. [Abstract] [PDF]
|
|
|
|
|
|
A Gonzalez-Reyes, H Elliott, and D St Johnston Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes Development, January 12, 1997; 124(24): 4927 - 4937. [Abstract] [PDF]
|
|
|
|
|
|
P Gonczy, E Matunis, and S DiNardo bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis Development, January 11, 1997; 124(21): 4361 - 4371. [Abstract] [PDF]
|
|
|
|
|
|
M McGrail and T. Hays The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila Development, January 6, 1997; 124(12): 2409 - 2419. [Abstract] [PDF]
|
|
|
|
|
|
C. Lehner and M. Lane Cell cycle regulators in Drosophila: downstream and part of developmental decisions J. Cell Sci., January 3, 1997; 110(5): 523 - 528. [Abstract] [PDF]
|
|
|
|
|
|
J.A. Knoblich, L.Y. Jan, and Y.N. Jan Asymmetric Segregation of the Drosophila Numb Protein during Mitosis: Facts and Speculations Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 71 - 77. [Abstract] [PDF]
|
|
|
|
|
|
I. Clark, L. Jan, and Y. Jan Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle Development, January 1, 1997; 124(2): 461 - 470. [Abstract] [PDF]
|
|
|
|
|
|
M A Lilly and A C Spradling The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion. Genes & Dev., October 1, 1996; 10(19): 2514 - 2526. [Abstract] [PDF]
|
|
|
|
|
|
M de Cuevas, J. Lee, and A. Spradling alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary Development, January 12, 1996; 122(12): 3959 - 3968. [Abstract] [PDF]
|
|
|
|
|
|
A Swan and B Suter Role of Bicaudal-D in patterning the Drosophila egg chamber in mid-oogenesis Development, January 11, 1996; 122(11): 3577 - 3586. [Abstract] [PDF]
|
|
|
|
|
|
C. Larabell, B. Rowning, J Wells,, M Wu, and J. Gerhart Confocal microscopy analysis of living Xenopus eggs and the mechanism of cortical rotation Development, January 4, 1996; 122(4): 1281 - 1289. [Abstract] [PDF]
|
|
|
|
|
|
K. Clark and D. McKearin The Drosophila stonewall gene encodes a putative transcription factor essential for germ cell development Development, January 3, 1996; 122(3): 937 - 950. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Heinlein, B. L. Epel, H. S. Padgett, and R. N. Beachy Interaction of Tobamovirus Movement Proteins with the Plant Cytoskeleton Science, December 22, 1995; 270(5244): 1983 - 1985. [Abstract] [PDF]
|
|
|
|
|
|
D E Gillespie and C A Berg Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases. Genes & Dev., October 15, 1995; 9(20): 2495 - 2508. [Abstract] [PDF]
|
|
|
|
|
|
T. Serano and R. Cohen A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA Development, January 11, 1995; 121(11): 3809 - 3818. [Abstract] [PDF]
|
|
|
|
|
|
D. Ruden and H Jackle Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm Development, January 1, 1995; 121(1): 63 - 73. [Abstract] [PDF]
|
|
|
|
|
|
M E Lane and D Kalderon RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization. Genes & Dev., December 15, 1994; 8(24): 2986 - 2995. [Abstract] [PDF]
|
|
|
|
|
|
L Cooley and W. Theurkauf Cytoskeletal functions during Drosophila oogenesis Science, October 28, 1994; 266(5185): 590 - 596. [Abstract] [PDF]
|
|
|
|
|
|
D. Robinson, K Cant, and L Cooley Morphogenesis of Drosophila ovarian ring canals Development, January 7, 1994; 120(7): 2015 - 2025. [Abstract] [PDF]
|
|
|
|
|
|
B Ran, R Bopp, and B Suter Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development Development, January 5, 1994; 120(5): 1233 - 1242. [Abstract] [PDF]
|
|
|
|
|
|
H Lin, L Yue, and A. Spradling The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation Development, January 4, 1994; 120(4): 947 - 956. [Abstract] [PDF]
|
|
