spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Downs, K. M.
Right arrow Articles by Davies, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Downs, K. M.
Right arrow Articles by Davies, T.

Development, Vol 118, Issue 4 1255-1266, Copyright © 1993 by Company of Biologists

JOURNAL ARTICLES

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope

KM Downs and T Davies
Department of Zoology, University of Oxford, UK.

We describe and illustrate a set of morphological landmarks for classifying mouse embryos by gross morphology from before gastrulation to the beginning of organogenesis. These landmarks are visible at the resolution of the dissecting microscope in embryos that are intact except for reflexion of Reichert's membrane. Adoption of these criteria should facilitate interpretation of both the expression patterns of genes and the consequences of experimental manipulation of embryos during early postimplantation development.


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
A. Sawada, H. Kiyonari, K. Ukita, N. Nishioka, Y. Imuta, and H. Sasaki
Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival
Mol. Cell. Biol., May 15, 2008; 28(10): 3177 - 3189.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Morey, N. R. Da Silva, M. Kmita, D. Duboule, and W. A. Bickmore
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd
J. Cell Sci., March 1, 2008; 121(5): 571 - 577.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Seki, M. Yamaji, Y. Yabuta, M. Sano, M. Shigeta, Y. Matsui, Y. Saga, M. Tachibana, Y. Shinkai, and M. Saitou
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
Development, July 15, 2007; 134(14): 2627 - 2638.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. Guo and J. Y. H. Li
Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation
Development, June 15, 2007; 134(12): 2251 - 2260.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
C. P. Gheorghe, S. Mohan, K. C. Oberg, and L. D. Longo
Gene Expression Patterns in the Hypoxic Murine Placenta: A Role in Epigenesis?
Reproductive Sciences, April 1, 2007; 14(3): 223 - 233.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. P. L. Tam, P.-L. Khoo, S. L. Lewis, H. Bildsoe, N. Wong, T. E. Tsang, J. M. Gad, and L. Robb
Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
Development, January 15, 2007; 134(2): 251 - 260.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Ema, T. Yokomizo, A. Wakamatsu, T. Terunuma, M. Yamamoto, and S. Takahashi
Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo
Blood, December 15, 2006; 108(13): 4018 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. M. Zeigler, D. Sugiyama, M. Chen, Y. Guo, K. M. Downs, and N. A. Speck
The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential
Development, November 1, 2006; 133(21): 4183 - 4192.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. A. Bosman, K. A. Lawson, J. Debruyn, L. Beek, A. Francis, L. Schoonjans, D. Huylebroeck, and A. Zwijsen
Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels
Development, September 1, 2006; 133(17): 3399 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. E. Inman and K. M. Downs
Brachyury is required for elongation and vasculogenesis in the murine allantois
Development, August 1, 2006; 133(15): 2947 - 2959.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Furuta, H. Ema, S.-i. Takayanagi, T. Ogaeri, D. Okamura, Y. Matsui, and H. Nakauchi
Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo.
Development, July 1, 2006; 133(14): 2771 - 2779.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
C. Gheorghe, S. Moham, and L. D. Longo
Gene Expression Patterns in the Developing Murine Placenta
Reproductive Sciences, May 1, 2006; 13(4): 256 - 262.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Jouneau, Q. Zhou, A. Camus, V. Brochard, L. Maulny, J. Collignon, and J.-P. Renard
Developmental abnormalities of NT mouse embryos appear early after implantation.
Development, April 1, 2006; 133(8): 1597 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Ema, S. Takahashi, and J. Rossant
Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors
Blood, January 1, 2006; 107(1): 111 - 117.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor
Development, November 1, 2005; 132(21): 4719 - 4729.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Y. Bertrand, A. Jalil, M. Klaine, S. Jung, A. Cumano, and I. Godin
Three pathways to mature macrophages in the early mouse yolk sac
Blood, November 1, 2005; 106(9): 3004 - 3011.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Nishioka, S. Nagano, R. Nakayama, H. Kiyonari, T. Ijiri, K. Taniguchi, W. Shawlot, Y. Hayashizaki, H. Westphal, R. R. Behringer, et al.
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
Development, June 1, 2005; 132(11): 2535 - 2546.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. O. Sirbu, L. Gresh, J. Barra, and G. Duester
Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression
Development, June 1, 2005; 132(11): 2611 - 2622.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Doyonnas, J. S. Nielsen, S. Chelliah, E. Drew, T. Hara, A. Miyajima, and K. M. McNagny
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells
Blood, June 1, 2005; 105(11): 4170 - 4178.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Chambeyron, N. R. Da Silva, K. A. Lawson, and W. A. Bickmore
Nuclear re-organisation of the Hoxb complex during mouse embryonic development
Development, May 1, 2005; 132(9): 2215 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. D. Vincent, N. R. Dunn, R. Sciammas, M. Shapiro-Shalef, M. M. Davis, K. Calame, E. K. Bikoff, and E. J. Robertson
The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse
Development, March 15, 2005; 132(6): 1315 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. Hitoshi, R. M. Seaberg, C. Koscik, T. Alexson, S. Kusunoki, I. Kanazawa, S. Tsuji, and D. van der Kooy
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling
Genes & Dev., August 1, 2004; 18(15): 1806 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. L. Bohnsack, L. Lai, P. Dolle, and K. K. Hirschi
Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation
Genes & Dev., June 1, 2004; 18(11): 1345 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. K. Nath, J. Enciso, M. Kuniyasu, X.-Y. Hao, J. A. Madri, and E. Pinter
Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy
Development, May 15, 2004; 131(10): 2485 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. J. Merrill, H. A. Pasolli, L. Polak, M. Rendl, M. J. Garcia-Garcia, K. V. Anderson, and E. Fuchs
Tcf3: a transcriptional regulator of axis induction in the early embryo
Development, January 15, 2004; 131(2): 263 - 274.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. M. Downs, E. R. Hellman, J. McHugh, K. Barrickman, and K. E. Inman
Investigation into a role for the primitive streak in development of the murine allantois
Development, January 1, 2004; 131(1): 37 - 55.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Okamura, T. Kimura, T. Nakano, and Y. Matsui
Cadherin-mediated cell interaction regulates germ cell determination in mice
Development, December 29, 2003; 130(26): 6423 - 6430.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Hochgreb, V. L. Linhares, D. C. Menezes, A. C. Sampaio, C. Y. I. Yan, W. V. Cardoso, N. Rosenthal, and J. Xavier-Neto
A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field
Development, November 15, 2003; 130(22): 5363 - 5374.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. J. Ferkowicz, M. Starr, X. Xie, W. Li, S. A. Johnson, W. C. Shelley, P. R. Morrison, and M. C. Yoder
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
Development, September 15, 2003; 130(18): 4393 - 4403.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. del Barco Barrantes, G. Davidson, H.-J. Grone, H. Westphal, and C. Niehrs
Dkk1 and noggin cooperate in mammalian head induction
Genes & Dev., September 15, 2003; 17(18): 2239 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Forlani, K. A. Lawson, and J. Deschamps
Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo
Development, August 15, 2003; 130(16): 3807 - 3819.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Yamamoto, N. Mine, K. Mochida, Y. Sakai, Y. Saijoh, C. Meno, and H. Hamada
Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate
Development, May 1, 2003; 130(9): 1795 - 1804.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. D. Uy, K. M. Downs, and R. L. Gardner
Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse
Development, March 10, 2003; 129(16): 3913 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. E. McGrath, A. D. Koniski, J. Malik, and J. Palis
Circulation is established in a stepwise pattern in the mammalian embryo
Blood, March 1, 2003; 101(5): 1669 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Xie, R. J. Chan, S. A. Johnson, M. Starr, J. McCarthy, R. Kapur, and M. C. Yoder
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs
Blood, February 15, 2003; 101(4): 1329 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. B. Madison, L. Dunbar, X. T. Qiao, K. Braunstein, E. Braunstein, and D. L. Gumucio
cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine
J. Biol. Chem., August 30, 2002; 277(36): 33275 - 33283.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith
Chordin and noggin promote organizing centers of forebrain development in the mouse
Development, January 11, 2002; 129(21): 4975 - 4987.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. J. Auman, T. Nottoli, O. Lakiza, Q. Winger, S. Donaldson, and T. Williams
Transcription factor AP-2{gamma} is essential in the extra-embryonic lineages for early postimplantation development
Development, January 6, 2002; 129(11): 2733 - 2747.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Kinder, T. E. Tsang, M. Wakamiya, H. Sasaki, R. R. Behringer, A. Nagy, and P. P. L. Tam
The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
Development, September 15, 2001; 128(18): 3623 - 3634.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Lee, N. Kertesz, S. B. Joseph, A. Jegalian, and H. Wu
Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis
Blood, September 1, 2001; 98(5): 1408 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Matsuoka, K. Tsuji, H. Hisakawa, M.-j. Xu, Y. Ebihara, T. Ishii, D. Sugiyama, A. Manabe, R. Tanaka, Y. Ikeda, et al.
Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells
Blood, July 1, 2001; 98(1): 6 - 12.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Wendling, N. B. Ghyselinck, P. Chambon, and M. Mark
Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning
Development, June 1, 2001; 128(11): 2031 - 2038.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
Genes & Dev., May 15, 2001; 15(10): 1242 - 1256.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Palis, R. J. Chan, A. Koniski, R. Patel, M. Starr, and M. C. Yoder
Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis
PNAS, April 10, 2001; 98(8): 4528 - 4533.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Development, January 5, 2001; 128(10): 1717 - 1730.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
Development, January 3, 2001; 128(5): 753 - 765.
[Abstract] [PDF]

Home page
 DevelopmentHome page
T Yoshimizu, M Obinata, and Y Matsui
Stage-specific tissue and cell interactions play key roles in mouse germ cell specification
Development, January 2, 2001; 128(4): 481 - 490.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Foley, I Skromne, and C. Stern
Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast
Development, January 9, 2000; 127(17): 3839 - 3854.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Camus, B. Davidson, S Billiards, P Khoo, J. Rivera-Perez, M Wakamiya, R. Behringer, and P. Tam
The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
Development, January 5, 2000; 127(9): 1799 - 1813.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Wells and D. Melton
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
Development, January 4, 2000; 127(8): 1563 - 1572.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Manaia, V Lemarchandel, M Klaine, I Max-Audit, P Romeo, F Dieterlen-Lievre, and I Godin
Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites
Development, January 2, 2000; 127(3): 643 - 653.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S. Kinder, T. Tsang, G. Quinlan, A. Hadjantonakis, A Nagy, and P. Tam
The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo
Development, January 11, 1999; 126(21): 4691 - 4701.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Palis, S Robertson, M Kennedy, C Wall, and G Keller
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
Development, January 11, 1999; 126(22): 5073 - 5084.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Tam and K. Steiner
Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
Development, January 11, 1999; 126(22): 5171 - 5179.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Perea-Gomez, W Shawlot, H Sasaki, R. Behringer, and S Ang
HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
Development, January 10, 1999; 126(20): 4499 - 4511.
[Abstract] [PDF]

Home page
 DevelopmentHome page
C Chazaud, P Chambon, and P Dolle
Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis
Development, January 6, 1999; 126(12): 2589 - 2596.
[Abstract] [PDF]

Home page
 DevelopmentHome page
T. Clark, S. Conway, I. Scott, P. Labosky, G Winnier, J Bundy, B. Hogan, and D. Greenspan
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart
Development, January 6, 1999; 126(12): 2631 - 2642.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Gotz, A. Probst, E. Ehler, B. Hemmings, and W. Kues
Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha
PNAS, October 13, 1998; 95(21): 12370 - 12375.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M Belaoussoff, S. Farrington, and M. Baron
Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo
Development, January 12, 1998; 125(24): 5009 - 5018.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K. Downs, S Gifford, M Blahnik, and R. Gardner
Vascularization in the murine allantois occurs by vasculogenesis without accompanying erythropoiesis
Development, January 11, 1998; 125(22): 4507 - 4520.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
C Biben and R P Harvey
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.
Genes & Dev., June 1, 1997; 11(11): 1357 - 1369.
[Abstract] [PDF]

Home page
 BloodHome page
L. Silver and J. Palis
Initiati