|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 118, Issue 4 1335-1342, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
SY Sokol
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA.
It is demonstrated here that the ability of injected Xwnt8 RNA to trigger mesoderm formation in Xenopus presumptive ectoderm (animal caps) depends on the time of explantation. Animal caps isolated from Xwnt8 injected embryos at the late blastula/early gastrula stages differentiate mesodermal tissues whereas caps isolated from early blastula do not. This finding suggests that an endogenous signal reaches the animal cap by the late blastula stage and cooperates with Xwnt8 to induce mesoderm. Similarly, late animal caps isolated at st. 10 from lithium-treated embryos, but not those from control embryos, elongate and express muscle-specific actin transcripts. In addition, the data presented suggests that the cooperating signal is distributed homogeneously with respect to the future dorsoventral axis and may require FGF- and activin-dependent signal transduction pathways. These observations support a model in which mesoderm is induced in vivo by a combined action of several different signals.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Chang and R. M. Harland Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation Development, November 1, 2007; 134(21): 3861 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cambray and V. Wilson Two distinct sources for a population of maturing axial progenitors Development, August 1, 2007; 134(15): 2829 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Itasaki, C. M. Jones, S. Mercurio, A. Rowe, P. M. Domingos, J. C. Smith, and R. Krumlauf Wise, a context-dependent activator and inhibitor of Wnt signalling Development, September 15, 2003; 130(18): 4295 - 4305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. O'Reilly, S. Pluskey, S. E. Shoelson, and B. G. Neel Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps Mol. Cell. Biol., January 1, 2000; 20(1): 299 - 311. [Abstract] [Full Text]
|
|
|
|
|
|
M Nagel and R Winklbauer Establishment of substratum polarity in the blastocoel roof of the Xenopus embryo Development, January 5, 1999; 126(9): 1975 - 1984. [Abstract] [PDF]
|
|
|
|
|
|
Q Xu, P. D'Amore, and S. Sokol Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist Development, January 12, 1998; 125(23): 4767 - 4776. [Abstract] [PDF]
|
|
|
|
|
|
M. Laurent, I. Blitz, C Hashimoto, U Rothbacher, and K. Cho The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer Development, January 12, 1997; 124(23): 4905 - 4916. [Abstract] [PDF]
|
|
|
|
|
|
C Wylie, M Kofron, C Payne, R Anderson, M Hosobuchi, E Joseph, and J Heasman Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos Development, January 10, 1996; 122(10): 2987 - 2996. [Abstract] [PDF]
|
|
|
|
|
|
T Holowacz and R. Elinson Properties of the dorsal activity found in the vegetal cortical cytoplasm of Xenopus eggs Development, January 9, 1995; 121(9): 2789 - 2798. [Abstract] [PDF]
|
|
|
|
|
|
K Kinoshita and M Asashima Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition Development, January 6, 1995; 121(6): 1581 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
S. Sokol, J Klingensmith, N Perrimon, and K Itoh Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled Development, January 6, 1995; 121(6): 1637 - 1647. [Abstract] [PDF]
|
|
|
|
|
|
G. Kelly, P Greenstein, D. Erezyilmaz, and R. Moon Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways Development, January 6, 1995; 121(6): 1787 - 1799. [Abstract] [PDF]
|
|
|
|
|
|
K. Itoh and S. Y. Sokol Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos Development, September 1, 1994; 120(9): 2703 - 2711. [Abstract] [PDF]
|
|
|
|
|
|
D. Bauer, S Huang, and S. Moody The cleavage stage origin of Spemann's Organizer: analysis of the movements of blastomere clones before and during gastrulation in Xenopus Development, January 5, 1994; 120(5): 1179 - 1189. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Lamb, A. Knecht, W. Smith, S. Stachel, A. Economides, N Stahl, G. Yancopolous, and R. Harland Neural induction by the secreted polypeptide noggin Science, October 29, 1993; 262(5134): 713 - 718. [Abstract] [PDF]
|
|
