|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 1 233-245, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
A Graham, I Heyman and A Lumsden
MRC Brain Development Programme, United Medical School, Guy's Hospital, London.
Neural crest cells originate at three discontinuous levels along the rostrocaudal axis of the chick rhombencephalon, centred on rhombomeres 1 and 2, 4 and 6, respectively. These are separated by the odd-numbered rhombomeres r3 and r5 which are depleted of migratory neural crest cells. Here we show elevated levels of apoptosis in the dorsal midline of r3 and r5, immediately following the formation of these rhombomeres at the developmental stage (10-12) when neural crest cells would be expected to emerge at these neuraxial levels. These regions are also marked by their expression of members of the msx family of homeobox genes with msx-2 expression preceding apoptosis in a precisely colocalised pattern. In vitro and in ovo experiments have revealed that r3 and r5 are depleted of neural crest cells by an interaction within the neural epithelium: if isolated or distanced from their normal juxtaposition with even-numbered rhombomeres, both r3 and r5 produce migrating neural crest cells. When r3 or r5 are unconstrained in this way, allowing production of crest, msx-2 expression is concomitantly down regulated. This suggests a correlation between msx-2 and the programming of apoptosis in this system. The hindbrain neural crest is thus produced in discrete streams by mechanisms intrinsic to the neural epithelium. The crest cells that enter the underlying branchial region are organised into streams before they encounter the mesodermal environment lateral to the neural tube. This contrasts sharply with the situation in the trunk where neural crest production is uninterrupted along the neuraxis and the segmental accumulation of neurogenic crest cells is subsequently founded on an alternation of permissive and non-permissive qualities of the local mesodermal environment.
This article has been cited by other articles:
|
|
 |
|
  S. Kuratani Is the vertebrate head segmented?--evolutionary and developmental considerations Integr. Comp. Biol., November 1, 2008; 48(5): 647 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kuratani and T. Schilling Head segmentation in vertebrates Integr. Comp. Biol., November 1, 2008; 48(5): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hoshino, T. Uchida, T. Otsuki, S. Kawamoto, K. Okubo, M. Takeichi, and O. Chisaka Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves Mol. Biol. Cell, April 1, 2007; 18(4): 1143 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Creuzet, S. Martinez, and N. M. Le Douarin The cephalic neural crest exerts a critical effect on forebrain and midbrain development PNAS, September 19, 2006; 103(38): 14033 - 14038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Teddy and P. M. Kulesa In vivo evidence for short- and long-range cell communication in cranial neural crest cells Development, December 15, 2004; 131(24): 6141 - 6151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Le Douarin, S. Creuzet, G. Couly, and E. Dupin Neural crest cell plasticity and its limits Development, October 1, 2004; 131(19): 4637 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Perez-Alcala, M. A. Nieto, and J. A. Barbas LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest Development, September 15, 2004; 131(18): 4455 - 4465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Creuzet, B. Schuler, G. Couly, and N. M. Le Douarin From the Cover: Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development PNAS, April 6, 2004; 101(14): 4843 - 4847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Trainor, D. Sobieszczuk, D. Wilkinson, and R. Krumlauf Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways Development, March 3, 2003; 129(2): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Berry Variety QJM, April 1, 2002; 95(4): 259 - 260. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cheng, S. L. Chan, O. Milhavet, S. Wang, and M. P. Mattson p38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells J. Biol. Chem., November 9, 2001; 276(46): 43320 - 43327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Begbie and A. Graham Integration Between the Epibranchial Placodes and the Hindbrain Science, October 19, 2001; 294(5542): 595 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest Development, August 1, 2001; 128(15): 3017 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ikeda, S. Ikeda, T. Gridley, P. M. Nishina, and J. K. Naggert Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice Hum. Mol. Genet., June 1, 2001; 10(12): 1325 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Kos, M. Reedy, R. Johnson, and C. Erickson The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos Development, January 4, 2001; 128(8): 1467 - 1479. [Abstract] [PDF]
|
|
|
|
|
|
D. Ellies, V Church, P Francis-West, and A Lumsden The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain Development, January 12, 2000; 127(24): 5285 - 5295. [Abstract] [PDF]
|
|
|
|
|
|
P Kulesa, M Bronner-Fraser, and S Fraser In ovo time-lapse analysis after dorsal neural tube ablation shows rerouting of chick hindbrain neural crest Development, January 7, 2000; 127(13): 2843 - 2852. [Abstract] [PDF]
|
|
|
|
|
|
P. Kulesa and S. Fraser In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches Development, January 3, 2000; 127(6): 1161 - 1172. [Abstract] [PDF]
|
|
|
|
|
|
U Borello, M Coletta, S Tajbakhsh, L Leyns, E. De Robertis, M Buckingham, and G Cossu Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos Development, January 10, 1999; 126(19): 4247 - 4255. [Abstract] [PDF]
|
|
|
|
|
|
B. Eickholt, S. Mackenzie, A Graham, F. Walsh, and P Doherty Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions Development, January 5, 1999; 126(10): 2181 - 2189. [Abstract] [PDF]
|
|
|
|
|
|
C. Baker, M. Stark, C Marcelle, and M Bronner-Fraser Competence, specification and induction of Pax-3 in the trigeminal placode Development, January 1, 1999; 126(1): 147 - 156. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Waschek, R. A. Casillas, T. B. Nguyen, E. M. DiCicco-Bloom, E. M. Carpenter, and W. I. Rodriguez Neural tube expression of pituitary adenylate cyclase-activating peptide (PACAP) and receptor: Potential role in patterning and neurogenesis PNAS, August 4, 1998; 95(16): 9602 - 9607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Helmbacher, C Pujades, C Desmarquet, M Frain, F. Rijli, P Chambon, and P Charnay Hoxa1 and Krox-20 synergize to control the development of rhombomere 3 Development, January 12, 1998; 125(23): 4739 - 4748. [Abstract] [PDF]
|
|
|
|
|
|
K Takahashi, G. Nuckolls, O Tanaka, I Semba, I Takahashi, R Dashner, L Shum, and H. Slavkin Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo Development, January 5, 1998; 125(9): 1627 - 1635. [Abstract] [PDF]
|
|
|
|
|
|
A Gavalas, M Studer, A Lumsden, F. Rijli, R Krumlauf, and P Chambon Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch Development, January 3, 1998; 125(6): 1123 - 1136. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Qiu, F. A. Pereira, F. J. DeMayo, J. P. Lydon, S. Y. Tsai, and M.-J. Tsai Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization Genes & Dev., August 1, 1997; 11(15): 1925 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Thomaidou, M. C. Mione, J. F. R. Cavanagh, and J. G. Parnavelas Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex J. Neurosci., February 1, 1997; 17(3): 1075 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Goh, J. Yang, and R. Hynes Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos Development, January 11, 1997; 124(21): 4309 - 4319. [Abstract] [PDF]
|
|
|
|
|
|
A Gavalas, M Davenne, A Lumsden, P Chambon, and F. Rijli Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning Development, January 10, 1997; 124(19): 3693 - 3702. [Abstract] [PDF]
|
|
|
|
|
|
M Maden, A Graham, E Gale, C Rollinson, and M Zile Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids Development, January 7, 1997; 124(14): 2799 - 2805. [Abstract] [PDF]
|
|
|
|
|
|
D. Choi, S. Ward, N Messaddeq, J. Launay, and L Maroteaux 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells Development, January 5, 1997; 124(9): 1745 - 1755. [Abstract] [PDF]
|
|
|
|
|
|
S Schneider-Maunoury, T Seitanidou, P Charnay, and A Lumsden Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants Development, January 3, 1997; 124(6): 1215 - 1226. [Abstract] [PDF]
|
|
|
|
|
|
B L Hogan Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes & Dev., July 1, 1996; 10(13): 1580 - 1594. [PDF]
|
|
|
|
|
|
G Kontges and A Lumsden Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny Development, January 10, 1996; 122(10): 3229 - 3242. [Abstract] [PDF]
|
|
|
|
|
|
C Niederlander and A Lumsden Late emigrating neural crest cells migrate specifically to the exit points of cranial branchiomotor nerves Development, January 8, 1996; 122(8): 2367 - 2374. [Abstract] [PDF]
|
|
|
|
|
|
J. Saldivar, C. Krull, R Krumlauf, L Ariza-McNaughton, and M Bronner-Fraser Rhombomere of origin determines autonomous versus environmentally regulated expression of Hoxa-3 in the avian embryo Development, January 3, 1996; 122(3): 895 - 904. [Abstract] [PDF]
|
|
|
|
|
|
A Graham and A Lumsden Interactions between rhombomeres modulate Krox-20 and follistatin expression in the chick embryo hindbrain Development, January 2, 1996; 122(2): 473 - 480. [Abstract] [PDF]
|
|
|
|
|
|
S Nonchev, C Vesque, M Maconochie, T Seitanidou, L Ariza-McNaughton, M Frain, H Marshall, M. Sham, R Krumlauf, and P Charnay Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20 Development, January 2, 1996; 122(2): 543 - 554. [Abstract] [PDF]
|
|
|
|
|
|
Z F Chen and R R Behringer twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes & Dev., March 15, 1995; 9(6): 686 - 699. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, L. McNaughton, R Krumlauf, and N. Le Douarin Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications Development, January 9, 1995; 121(9): 2707 - 2721. [Abstract] [PDF]
|
|
|
|
|
|
R Mahmood, P Kiefer, S Guthrie, C Dickson, and I Mason Multiple roles for FGF-3 during cranial neural development in the chicken Development, January 5, 1995; 121(5): 1399 - 1410. [Abstract] [PDF]
|
|
|
|
|
|
J. Grindley, D. Davidson, and R. Hill The role of Pax-6 in eye and nasal development Development, January 5, 1995; 121(5): 1433 - 1442. [Abstract] [PDF]
|
|
|
|
|
|
R. Conlon, A. Reaume, and J Rossant Notch1 is required for the coordinate segmentation of somites Development, January 5, 1995; 121(5): 1533 - 1545. [Abstract] [PDF]
|
|
|
|
|
|
E Birgbauer, J Sechrist, M Bronner-Fraser, and S Fraser Rhombomeric origin and rostrocaudal reassortment of neural crest cells revealed by intravital microscopy Development, January 4, 1995; 121(4): 935 - 945. [Abstract] [PDF]
|
|
|
|
|
|
I. McKay, I Muchamore, R Krumlauf, M Maden, A Lumsden, and J Lewis The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres Development, January 8, 1994; 120(8): 2199 - 2211. [Abstract] [PDF]
|
|
|
|
|
|
J Sechrist, T Scherson, and M Bronner-Fraser Rhombomere rotation reveals that multiple mechanisms contribute to the segmental pattern of hindbrain neural crest migration Development, January 7, 1994; 120(7): 1777 - 1790. [Abstract] [PDF]
|
|
|
|
|
|
V Prince and A Lumsden Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest Development, January 4, 1994; 120(4): 911 - 923. [Abstract] [PDF]
|
|
