|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 1 41-48, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
JM Brown, SE Wedden, GH Millburn, LG Robson, RE Hill, DR Davidson and C Tickle
Department of Anatomy and Developmental Biology, University College and Middlesex School of Medicine, London, UK.
Mouse mesenchyme was grafted into chick embryos to investigate the control of mesenchymal expression of Msx-1 in the developing limb and face. In situ hybridization, using species-specific probes, allows a comparison between Msx-1 expression in the graft and the host tissue. The results show that Msx-1 expression in both limb-to-limb and face-to-face grafts corresponds closely with the level of Msx-1 expression in the surrounding chick mesenchyme. Cells in grafts that end up within the host domain of Msx-1 express the gene irrespective of whether they were from normally expressing, or non-expressing, regions. Therefore Msx-1 expression in both the developing limb and the developing face appears to be position-dependent. Mesenchyme from each of the three major facial primordia behaved in the same way when grafted to the chick maxillary primordium. Reciprocal grafts between face and limb gave a different result: Msx-1 expression was activated when facial mesenchyme was grafted to the limb but not when limb mesenchyme was grafted to the face. This suggests either that there are quantitative or qualitative differences in two local signalling systems or that additional factors determine the responsiveness of the mesenchyme cells.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. E. Coudert, L. Pibouin, B. Vi-Fane, B. L. Thomas, M. Macdougall, A. Choudhury, B. Robert, P. T. Sharpe, A. Berdal, and F. Lezot Expression and regulation of the Msx1 natural antisense transcript during development Nucleic Acids Res., September 12, 2005; 33(16): 5208 - 5218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-X. Xu, W. Zheng, C. Laclef, P. Maire, R. L. Maas, H. Peters, and X. Xu Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid Development, January 7, 2002; 129(13): 3033 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mina Regulation of Mandibular Growth and Morphogenesis Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(4): 276 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hollnagel, V. Oehlmann, J. Heymer, U. Ruther, and A. Nordheim Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells J. Biol. Chem., July 9, 1999; 274(28): 19838 - 19845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tucker, A Al Khamis, C. Ferguson, I Bach, M. Rosenfeld, and P. Sharpe Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development Development, January 1, 1999; 126(2): 221 - 228. [Abstract] [PDF]
|
|
|
|
|
|
T Thomas, H Kurihara, H Yamagishi, Y Kurihara, Y Yazaki, E. Olson, and D Srivastava A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme Development, January 8, 1998; 125(16): 3005 - 3014. [Abstract] [PDF]
|
|
|
|
|
|
G. Serbedzija, J. Chen, and M. Fishman Regulation in the heart field of zebrafish Development, January 3, 1998; 125(6): 1095 - 1101. [Abstract] [PDF]
|
|
|
|
|
|
R. Maas and M. Bei The Genetic Control of Early Tooth Development Critical Reviews in Oral Biology & Medicine, January 1, 1997; 8(1): 4 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Chen, M Bei, I Woo, I Satokata, and R Maas Msx1 controls inductive signaling in mammalian tooth morphogenesis Development, January 10, 1996; 122(10): 3035 - 3044. [Abstract] [PDF]
|
|
|
|
|
|
K Patel, R Nittenberg, D D'Souza, C Irving, D Burt, D. Wilkinson, and C Tickle Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds Development, January 4, 1996; 122(4): 1147 - 1155. [Abstract] [PDF]
|
|
