|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 1 97-111, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
RT Moon, RM Campbell, JL Christian, LL McGrew, J Shih and S Fraser
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
To contribute to an understanding of the roles and mechanisms of action of Wnts in early vertebrate development, we have characterized the normal expression of Xenopus laevis Wnt-5A, and investigated the consequences of misexpression of this putative signalling factor. Xwnt-5A transcripts are expressed throughout development, and are enriched in both the anterior and posterior regions of embryos at late stages of development, where they are found primarily in ectoderm, with lower levels of expression in mesoderm. Overexpression of Xwnt-5A in Xenopus embryos leads to complex malformations distinct from those achieved by ectopic expression of Xwnts -1, -3A, or -8. This phenotype is unlikely to result from Xwnt-5A acting as an inducing agent, as overexpression of Xwnt-5A does not rescue dorsal structures in UV-irradiated embryos, does not induce mesoderm in blastula caps, and Xwnt-5A does not alter the endogenous patterns of expression of goosecoid, Xbra, or Xwnt-8. To pursue whether Xwnt-5A has the capacity to affect morphogenetic movements, we investigated whether overexpression of Xwnt-5A alters the normal elongation of blastula cap explants induced by activin. Intriguingly, Xwnt-5A blocks the elongation of blastula caps in response to activin, without blocking the differentiation of either dorsal or ventral mesoderm within these explants. The data are consistent with Xwnt-5A having the potential activity of modifying the morphogenetic movements of tissues.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Itoh, A. Jenny, M. Mlodzik, and S. Y. Sokol Centrosomal localization of Diversin and its relevance to Wnt signaling J. Cell Sci., October 15, 2009; 122(20): 3791 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy Mol. Cancer Ther., August 1, 2009; 8(8): 2103 - 2109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Yen, M. Williams, A. Periasamy, M. Conaway, C. Burdsal, R. Keller, X. Lu, and A. Sutherland PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation Development, June 15, 2009; 136(12): 2039 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Medrek, G. Landberg, T. Andersson, and K. Leandersson Wnt-5a-CKI{alpha} Signaling Promotes {beta}-Catenin/E-Cadherin Complex Formation and Intercellular Adhesion in Human Breast Epithelial Cells J. Biol. Chem., April 17, 2009; 284(16): 10968 - 10979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kim, S.-M. Cheong, J. Ryu, H.-J. Jung, E.-h. Jho, and J.-K. Han Xenopus Wntless and the Retromer Complex Cooperate To Regulate XWnt4 Secretion Mol. Cell. Biol., April 15, 2009; 29(8): 2118 - 2128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Adell, E. Salo, M. Boutros, and K. Bartscherer Smed-Evi/Wntless is required for {beta}-catenin-dependent and -independent processes during planarian regeneration Development, March 15, 2009; 136(6): 905 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. He, W. Xiong, X. Yu, R. Espinoza-Lewis, C. Liu, S. Gu, M. Nishita, K. Suzuki, G. Yamada, Y. Minami, et al. Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development Development, December 1, 2008; 135(23): 3871 - 3879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Cha, E. Tadjuidje, Q. Tao, C. Wylie, and J. Heasman Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation Development, November 15, 2008; 135(22): 3719 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Garcia-Garcia, M. Shibata, and K. V. Anderson Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo Development, September 15, 2008; 135(18): 3053 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M Freisinger, I. Schneider, T. A Westfall, and D. C Slusarski Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning Phil Trans R Soc B, April 12, 2008; 363(1495): 1377 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamamoto, S. K. Yoo, M. Nishita, A. Kikuchi, and Y. Minami Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells, November 1, 2007; 12(11): 1215 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishita, S. K. Yoo, A. Nomachi, S. Kani, N. Sougawa, Y. Ohta, S. Takada, A. Kikuchi, and Y. Minami Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration J. Cell Biol., November 20, 2006; 175(4): 555 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borchers, Y. Fonar, D. Frank, and J. C. Baker XNF-ATc3 affects neural convergent extension Development, May 1, 2006; 133(9): 1745 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Ewald, S. M. Peyrot, J. M. Tyszka, S. E. Fraser, and J. B. Wallingford Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formation Development, December 15, 2004; 131(24): 6195 - 6209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Gonzalez-Sancho, K. R. Brennan, L. A. Castelo-Soccio, and A. M. C. Brown Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize {beta}-Catenin Mol. Cell. Biol., June 1, 2004; 24(11): 4757 - 4768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Uemura and Y. Shimada Breaking Cellular Symmetry along Planar Axes in Drosophila and Vertebrates J. Biochem., November 1, 2003; 134(5): 625 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt Frizzled signalling and cell polarisation in Drosophila and vertebrates Development, October 1, 2003; 130(19): 4501 - 4513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Westfall, R. Brimeyer, J. Twedt, J. Gladon, A. Olberding, M. Furutani-Seiki, and D. C. Slusarski Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/{beta}-catenin activity J. Cell Biol., September 1, 2003; 162(5): 889 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ohkawara, T. S. Yamamoto, M. Tada, and N. Ueno Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development, May 15, 2003; 130(10): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hikasa, M. Shibata, I. Hiratani, and M. Taira The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling Development, March 13, 2003; 129(22): 5227 - 5239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Keller Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements Science, December 6, 2002; 298(5600): 1950 - 1954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Holmen, A. Salic, C. R. Zylstra, M. W. Kirschner, and B. O. Williams A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate beta -Catenin-dependent Signaling J. Biol. Chem., September 13, 2002; 277(38): 34727 - 34735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dumstrei, F. Wang, D. Shy, U. Tepass, and V. Hartenstein Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis Development, September 1, 2002; 129(17): 3983 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. van Gijn, M. J.A.P. Daemen, J. F.M. Smits, and W.M. Blankesteijn The wnt-frizzled cascade in cardiovascular disease Cardiovasc Res, July 1, 2002; 55(1): 16 - 24. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jonsson, J. Dejmek, P.-O. Bendahl, and T. Andersson Loss of Wnt-5a Protein Is Associated with Early Relapse in Invasive Ductal Breast Carcinomas Cancer Res., January 1, 2002; 62(2): 409 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Helmbrecht, A. Kispert, R. von Wasielewski, and G. Brabant Identification of a Wnt/{beta}-Catenin Signaling Pathway in Human Thyroid Cells Endocrinology, December 1, 2001; 142(12): 5261 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kiecker and C. Niehrs A morphogen gradient of Wnt/{beta}-catenin signalling regulates anteroposterior neural patterning in Xenopus Development, November 1, 2001; 128(21): 4189 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Skromne and C. D. Stern Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo Development, August 1, 2001; 128(15): 2915 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Maglia, L. A. Pugener, and L. Trueb Comparative Development of Anurans: Using Phylogeny to Understand Ontogeny Integr. Comp. Biol., June 1, 2001; 41(3): 538 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Liu, A. J. DeCostanzo, X. Liu, H.-y. Wang, S. Hallagan, R. T. Moon, and C. C. Malbon G Protein Signaling from Activated Rat Frizzled-1 to the beta -Catenin-Lef-Tcf Pathway Science, June 1, 2001; 292(5522): 1718 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Schneider and M. Mercola Wnt antagonism initiates cardiogenesis in Xenopus laevis Genes & Dev., February 1, 2001; 15(3): 304 - 315. [Abstract] [Full Text]
|
|
|
|
|
|
M. Tada and J. C. Smith Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway Development, May 15, 2000; 127(10): 2227 - 2238. [Abstract] [PDF]
|
|
|
|
|
|
C Hartmann and C. Tabin Dual roles of Wnt signaling during chondrogenesis in the chicken limb Development, January 7, 2000; 127(14): 3141 - 3159. [Abstract] [PDF]
|
|
|
|
|
|
S Sumanas, P Strege, J Heasman, and S. Ekker The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning Development, January 5, 2000; 127(9): 1981 - 1990. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Baker, R. S.P. Beddington, and R. M. Harland Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development Genes & Dev., December 1, 1999; 13(23): 3149 - 3159. [Abstract] [Full Text]
|
|
|
|
|
|
K. Itoh and S. Y. Sokol Axis determination by inhibition of Wnt signaling in Xenopus Genes & Dev., September 1, 1999; 13(17): 2328 - 2336. [Abstract] [Full Text]
|
|
|
|
|
|
K Wunnenberg-Stapleton, I. Blitz, C Hashimoto, and K. Cho Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development Development, January 12, 1999; 126(23): 5339 - 5351. [Abstract] [PDF]
|
|
|
|
|
|
T. Yamaguchi, A Bradley, A. McMahon, and S Jones A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo Development, January 3, 1999; 126(6): 1211 - 1223. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Axelrod, J. R. Miller, J. M. Shulman, R. T. Moon, and N. Perrimon Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways Genes & Dev., August 15, 1998; 12(16): 2610 - 2622. [Abstract] [Full Text]
|
|
|
|
|
|
S.-C. Hsu, J. Galceran, and R. Grosschedl Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with beta -Catenin Mol. Cell. Biol., August 1, 1998; 18(8): 4807 - 4818. [Abstract] [Full Text]
|
|
|
|
|
|
Q Xu, P. D'Amore, and S. Sokol Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist Development, January 12, 1998; 125(23): 4767 - 4776. [Abstract] [PDF]
|
|
|
|
|
|
M. Deardorff, C Tan, L. Conrad, and P. Klein Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis Development, January 7, 1998; 125(14): 2687 - 2700. [Abstract] [PDF]
|
|
|
|
 |
|
 J.-P. Saint-Jeannet, X. He, H. E. Varmus, and I. B. Dawid Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a PNAS, December 9, 1997; 94(25): 13713 - 13718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lin, S. Wang, M. A. Julius, J. Kitajewski, M. Moos Jr., and F. P. Luyten The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling PNAS, October 14, 1997; 94(21): 11196 - 11200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Larabell, M. Torres, B. A. Rowning, C. Yost, J. R. Miller, M. Wu, D. Kimelman, and R. T. Moon Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in {beta}-Catenin That Are Modulated by the Wnt Signaling Pathway J. Cell Biol., March 10, 1997; 136(5): 1123 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Salic, K. Kroll, L. Evans, and M. Kirschner Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos Development, January 12, 1997; 124(23): 4739 - 4748. [Abstract] [PDF]
|
|
|
|
 |
|
 G.-J. Rauch, M. Hammerschmidt, P. Blader, H.E. Schauerte, U. Strahle, P.W. Ingham, A.P. McMahon, and P. Haffter WNT5 Is Required for Tail Formation in the Zebrafish Embryo Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 227 - 234. [Abstract] [PDF]
|
|
|
|
|
|
F Fagotto, K Guger, and B. Gumbiner Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin Development, January 1, 1997; 124(2): 453 - 460. [Abstract] [PDF]
|
|
|
|
|
|
C. Eisenberg, R. Gourdie, and L. Eisenberg Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6 Development, January 1, 1997; 124(2): 525 - 536. [Abstract] [PDF]
|
|
|
|
|
|
C Yost, M Torres, J R Miller, E Huang, D Kimelman, and R T Moon The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes & Dev., June 15, 1996; 10(12): 1443 - 1454. [Abstract] [PDF]
|
|
|
|
|
|
T Watabe, S Kim, A Candia, U Rothbacher, C Hashimoto, K Inoue, and K W Cho Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes & Dev., December 15, 1995; 9(24): 3038 - 3050. [Abstract] [PDF]
|
|
|
|
|
|
Y Cui, J. Brown, R. Moon, and J. Christian Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis Development, January 7, 1995; 121(7): 2177 - 2186. [Abstract] [PDF]
|
|
|
|
|
|
G. Kelly, P Greenstein, D. Erezyilmaz, and R. Moon Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways Development, January 6, 1995; 121(6): 1787 - 1799. [Abstract] [PDF]
|
|
|
|
|
|
D. Kessler and D. Melton Vertebrate embryonic induction: mesodermal and neural patterning Science, October 28, 1994; 266(5185): 596 - 604. [Abstract] [PDF]
|
|
