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Development, Vol 119, Issue 3 799-812, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
D Godt, JL Couderc, SE Cramton and FA Laski
Department of Biology, University of California at Los Angeles 90024.
We have identified the gene bric a brac and show that it is required for pattern formation along the proximal-distal axis of the leg and antenna of Drosophila. In bric a brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal tarsal segment. In addition, bric a brac mutant legs and antennae have segmentation defects. bric a brac encodes a nuclear protein that shares a highly conserved domain with two transcription factors from Drosophila. bric a brac function is dosage dependent and is required in a graded manner for the specification of tarsal segments. The graded requirement for bric a brac correlates with its graded expression pattern, suggesting that the concentration of BRIC A BRAC protein specifies segment identity in the tarsus.
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