|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 3 897-908, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
B Oliver, YJ Kim and BS Baker
Department of Biological Sciences, Stanford University, CA 94305.
Female sex determination in the germ line of Drosophila melanogaster is regulated by genes functioning in the soma as well as genes that function within the germ line. Genes known or suspected to be involved in germ-line sex determination in Drosophila melanogaster have been examined to determine if they are required upstream or downstream of Sex-lethal+, a known germ-line sex determination gene. Seven genes required for female-specific splicing of germ-line Sex-lethal+ pre-mRNA are identified. These results together with information about the tissues in which these genes function and whether they control sex determination and viability or just sex determination in the germ line have been used to deduce the genetic hierarchy regulating female germ-line sex determination. This hierarchy includes the somatic sex determination genes transformer+, transformer-2+ and doublesex+ (and by inference Sex-lethal+), which control a somatic signal required for female germ-line sex determination, and the germ-line ovarian tumor genes fused+, ovarian tumor+, ovo+, sans fille+, and Sex-lethal+, which are involved in either the reception or interpretation of this somatic sex determination signal. The fused+, ovarian tumor+, ovo+ and sans fille+ genes function upstream of Sex-lethal+ in the germ line.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. L. Casper and M. Van Doren The establishment of sexual identity in the Drosophila germline Development, November 15, 2009; 136(22): 3821 - 3830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chau, L. S. Kulnane, and H. K. Salz Sex-lethal Facilitates the Transition From Germline Stem Cell to Committed Daughter Cell in the Drosophila Ovary Genetics, May 1, 2009; 182(1): 121 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sun and T. W. Cline Effects of Wolbachia Infection and ovarian tumor Mutations on Sex-lethal Germline Functioning in Drosophila Genetics, April 1, 2009; 181(4): 1291 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Siera and T. W. Cline Sexual Back Talk With Evolutionary Implications: Stimulation of the Drosophila Sex-Determination Gene Sex-lethal by Its Target transformer Genetics, December 1, 2008; 180(4): 1963 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Casper and M. Van Doren The control of sexual identity in the Drosophila germline Development, August 1, 2006; 133(15): 2783 - 2791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. O. F. Penalva and L. Sanchez RNA Binding Protein Sex-Lethal (Sxl) and Control of Drosophila Sex Determination and Dosage Compensation Microbiol. Mol. Biol. Rev., September 1, 2003; 67(3): 343 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Nagengast, S. M. Stitzinger, C.-H. Tseng, S. M. Mount, and H. K. Salz Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping Development, February 1, 2003; 130(3): 463 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Andrews and B. Oliver Sex Determination Signals Control ovo-B Transcription in Drosophila melanogaster Germ Cells Genetics, February 1, 2002; 160(2): 537 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Lu and B Oliver Drosophila OVO regulates ovarian tumor transcription by binding unusually near the transcription start site Development, January 5, 2001; 128(9): 1671 - 1686. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Waterbury, J. I. Horabin, D. Bopp, and P. Schedl Sex Determination in the Drosophila Germline Is Dictated by the Sexual Identity of the Surrounding Soma Genetics, August 1, 2000; 155(4): 1741 - 1756. [Abstract] [Full Text]
|
|
|
|
|
|
P Chen and R. Ellis TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans Development, January 7, 2000; 127(14): 3119 - 3129. [Abstract] [PDF]
|
|
|
|
|
|
C Schutt and R Nothiger Structure, function and evolution of sex-determining systems in Dipteran insects Development, January 2, 2000; 127(4): 667 - 677. [Abstract] [PDF]
|
|
|
|
|
|
J Andrews, D Garcia-Estefania, I Delon, J Lu, M Mevel-Ninio, A Spierer, F Payre, D Pauli, and B Oliver OVO transcription factors function antagonistically in the Drosophila female germline Development, January 2, 2000; 127(4): 881 - 892. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Kim-Ha, J. Kim, and Y.-J. Kim Requirement of RBP9, a Drosophila Hu Homolog, for Regulation of Cystocyte Differentiation and Oocyte Determination during Oogenesis Mol. Cell. Biol., April 1, 1999; 19(4): 2505 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Bhattacharya, S Sudha, H. Chandra, and R Steward flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal Development, January 12, 1999; 126(23): 5485 - 5493. [Abstract] [PDF]
|
|
|
|
|
|
D Bopp, C Schutt, J Puro, H Huang, and R Nothiger Recombination and disjunction in female germ cells of Drosophila depend on the germline activity of the gene sex-lethal Development, January 12, 1999; 126(24): 5785 - 5794. [Abstract] [PDF]
|
|
|
|
|
|
S Hinson and R. Nagoshi Regulatory and functional interactions between the somatic sex regulatory gene transformer and the germline genes ovo and ovarian tumor Development, January 2, 1999; 126(5): 861 - 871. [Abstract] [PDF]
|
|
|
|
|
|
C SchuLtt, A Hilfiker, and R Nothiger virilizer regulates Sex-lethal in the germline of Drosophila melanogaster Development, January 4, 1998; 125(8): 1501 - 1507. [Abstract] [PDF]
|
|
|
|
|
|
J. Hager and T. Cline Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination Development, January 12, 1997; 124(24): 5033 - 5048. [Abstract] [PDF]
|
|
|
|
|
|
P Gonczy, E Matunis, and S DiNardo bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis Development, January 11, 1997; 124(21): 4361 - 4371. [Abstract] [PDF]
|
|
|
|
|
|
S Staab, A Heller, and M Steinmann-Zwicky Somatic sex-determining signals act on XX germ cells in Drosophila embryos Development, January 12, 1996; 122(12): 4065 - 4071. [Abstract] [PDF]
|
|
|
|
|
|
M Mevel-Ninio, E Fouilloux, I Guenal, and A Vincent The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons Development, January 12, 1996; 122(12): 4131 - 4138. [Abstract] [PDF]
|
|
|
|
|
|
M. Pultz and B. Baker The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy Development, January 1, 1995; 121(1): 99 - 111. [Abstract] [PDF]
|
|
|
|
 |
|
 J Wang and L R Bell The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation. Genes & Dev., September 1, 1994; 8(17): 2072 - 2085. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Parkhurst and P. Meneely Sex determination and dosage compensation: lessons from flies and worms Science, May 13, 1994; 264(5161): 924 - 932. [Abstract] [PDF]
|
|
|
|
|
|
T W Flickinger and H K Salz The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes & Dev., April 15, 1994; 8(8): 914 - 925. [Abstract] [PDF]
|
|
|
|
|
|
B Oliver, J Singer, V Laget, G Pennetta, and D Pauli Function of Drosophila ovo+ in germ-line sex determination depends on X-chromosome number Development, January 11, 1994; 120(11): 3185 - 3195. [Abstract] [PDF]
|
|
