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Development, Vol 119, Issue 4 1079-1091, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
EL George, EN Georges-Labouesse, RS Patel-King, H Rayburn and RO Hynes
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.
To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal. When homozygous, the mutant allele causes early embryonic lethality, proving that fibronectin is required for embryogenesis. However, homozygous mutant embryos implant and initiate gastrulation normally including extensive mesodermal movement. Neural folds also form but the mutant embryos subsequently display shortened anterior-posterior axes, deformed neural tubes and severe defects in mesodermally derived tissues. Notochord and somites are absent; the heart and embryonic vessels are variable and deformed, and the yolk sac, extraembryonic vasculature and amnion are also defective. These abnormalities can be interpreted as arising from fundamental deficits in mesodermal migration, adhesion, proliferation or differentiation as a result of the absence of fibronectin. The nature of these embryonic defects leads to reevaluation of suggested roles for fibronectin during early development based on results obtained in vitro and in embryos of other species.
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D. M. McKean, L. Sisbarro, D. Ilic, N. Kaplan-Alburquerque, R. Nemenoff, M. Weiser-Evans, M. J. Kern, and P. L. Jones FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration J. Cell Biol., April 28, 2003; 161(2): 393 - 402. [Abstract] [Full Text] [PDF]
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A. Sudhakar, H. Sugimoto, C. Yang, J. Lively, M. Zeisberg, and R. Kalluri Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha vbeta 3 and alpha 5beta 1 integrins PNAS, April 15, 2003; 100(8): 4766 - 4771. [Abstract] [Full Text] [PDF]
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F. Amersi, X.-D. Shen, C. Moore, J. Melinek, R. W. Busuttil, J. W. Kupiec-Weglinski, and A. J. Coito Fibronectin-{alpha}4{beta}1 Integrin-Mediated Blockade Protects Genetically Fat Zucker Rat Livers from Ischemia/Reperfusion Injury Am. J. Pathol., April 1, 2003; 162(4): 1229 - 1239. [Abstract] [Full Text] [PDF]
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H. Ni, P. S. T. Yuen, J. M. Papalia, J. E. Trevithick, T. Sakai, R. Fassler, R. O. Hynes, and D. D. Wagner Plasma fibronectin promotes thrombus growth and stability in injured arterioles PNAS, March 4, 2003; 100(5): 2415 - 2419. [Abstract] [Full Text] [PDF]
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D. Ilic, B. Kovacic, S. McDonagh, F. Jin, C. Baumbusch, D. G. Gardner, and C. H. Damsky Focal Adhesion Kinase Is Required for Blood Vessel Morphogenesis Circ. Res., February 21, 2003; 92(3): 300 - 307. [Abstract] [Full Text] [PDF]
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E. H.J. Danen, P. Sonneveld, C. Brakebusch, R. Fassler, and A. Sonnenberg The fibronectin-binding integrins {alpha}5{beta}1 and {alpha}v{beta}3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis J. Cell Biol., December 23, 2002; 159(6): 1071 - 1086. [Abstract] [Full Text] [PDF]
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R. Pankov and K. M. Yamada Fibronectin at a glance J. Cell Sci., October 15, 2002; 115(20): 3861 - 3863. [Full Text] [PDF]
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 T. Fukuda, N. Yoshida, Y. Kataoka, R.-i. Manabe, Y. Mizuno-Horikawa, M. Sato, K. Kuriyama, N. Yasui, and K. Sekiguchi Mice Lacking the EDB Segment of Fibronectin Develop Normally but Exhibit Reduced Cell Growth and Fibronectin Matrix Assembly in Vitro Cancer Res., October 1, 2002; 62(19): 5603 - 5610. [Abstract] [Full Text] [PDF]
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J. Sottile and D. C. Hocking Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions Mol. Biol. Cell, October 1, 2002; 13(10): 3546 - 3559. [Abstract] [Full Text] [PDF]
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S. Klein, A. R. de Fougerolles, P. Blaikie, L. Khan, A. Pepe, C. D. Green, V. Koteliansky, and F. G. Giancotti {alpha}5{beta}1 Integrin Activates an NF-{kappa}B-Dependent Program of Gene Expression Important for Angiogenesis and Inflammation Mol. Cell. Biol., August 15, 2002; 22(16): 5912 - 5922. [Abstract] [Full Text] [PDF]
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 H. Y. Wang, J. Zhou, K. Zhu, A. I. Riker, F. M. Marincola, and R.-F. Wang Identification of a Mutated Fibronectin As a Tumor Antigen Recognized by CD4+T Cells: Its Role in Extracellular Matrix Formation and Tumor Metastasis J. Exp. Med., June 3, 2002; 195(11): 1397 - 1406. [Abstract] [Full Text] [PDF]
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S. E. Francis, K. L. Goh, K. Hodivala-Dilke, B. L. Bader, M. Stark, D. Davidson, and R. O. Hynes Central Roles of {alpha}5{beta}1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies Arterioscler Thromb Vasc Biol, June 1, 2002; 22(6): 927 - 933. [Abstract] [Full Text] [PDF]
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J. K. Sengbusch, W. He, K. A. Pinco, and J. T. Yang Dual functions of {alpha}4{beta}1 integrin in epicardial development: initial migration and long-term attachment J. Cell Biol., May 28, 2002; 157(5): 873 - 882. [Abstract] [Full Text] [PDF]
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I. Wierzbicka-Patynowski and J. E. Schwarzbauer Regulatory Role for Src and Phosphatidylinositol 3-Kinase in Initiation of Fibronectin Matrix Assembly J. Biol. Chem., May 24, 2002; 277(22): 19703 - 19708. [Abstract] [Full Text] [PDF]
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Y.-F. Liao, P. J. Gotwals, V. E. Koteliansky, D. Sheppard, and L. Van De Water The EIIIA Segment of Fibronectin Is a Ligand for Integrins alpha 9beta 1 and alpha 4beta 1 Providing a Novel Mechanism for Regulating Cell Adhesion by Alternative Splicing J. Biol. Chem., April 19, 2002; 277(17): 14467 - 14474. [Abstract] [Full Text] [PDF]
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L. A. Cary, R. A. Klinghoffer, C. Sachsenmaier, and J. A. Cooper Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading Mol. Cell. Biol., April 15, 2002; 22(8): 2427 - 2440. [Abstract] [Full Text] [PDF]
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T. Ohashi, D. P. Kiehart, and H. P. Erickson Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants J. Cell Sci., March 15, 2002; 115(6): 1221 - 1229. [Abstract] [Full Text] [PDF]
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D.J. Bloor, A.D. Metcalfe, A. Rutherford, D.R. Brison, and S.J. Kimber Expression of cell adhesion molecules during human preimplantation embryo development Mol. Hum. Reprod., March 1, 2002; 8(3): 237 - 245. [Abstract] [Full Text] [PDF]
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M. Hagel, E. L. George, A. Kim, R. Tamimi, S. L. Opitz, C. E. Turner, A. Imamoto, and S. M. Thomas The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling Mol. Cell. Biol., February 1, 2002; 22(3): 901 - 915. [Abstract] [Full Text] [PDF]
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 J. E. Michaelson, J. D. Ritzenthaler, and J. Roman Regulation of serum-induced fibronectin expression by protein kinases, cytoskeletal integrity, and CREB Am J Physiol Lung Cell Mol Physiol, February 1, 2002; 282(2): L291 - L301. [Abstract] [Full Text] [PDF]
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 R.O. HYNES, J.C. LIVELY, J.H. MCCARTY, D. TAVERNA, S.E. FRANCIS, K. HODIVALA-DILKE, and Q. XIAO The Diverse Roles of Integrins and Their Ligands in Angiogenesis Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 143 - 154. [Abstract] [PDF]
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C. Urbich, E. Dernbach, A. Reissner, M. Vasa, A. M. Zeiher, and S. Dimmeler Shear Stress-Induced Endothelial Cell Migration Involves Integrin Signaling Via the Fibronectin Receptor Subunits {alpha}5 and {beta}1 Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 69 - 75. [Abstract] [Full Text] [PDF]
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F. Charron, G. Tsimiklis, M. Arcand, L. Robitaille, Q. Liang, J. D. Molkentin, S. Meloche, and M. Nemer Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA Genes & Dev., October 15, 2001; 15(20): 2702 - 2719. [Abstract] [Full Text] [PDF]
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