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Development, Vol 119, Issue 4 1093-1105, Copyright © 1993 by Company of Biologists


JOURNAL ARTICLES

Embryonic mesodermal defects in alpha 5 integrin-deficient mice

JT Yang, H Rayburn and RO Hynes
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

A loss of function mutation of the murine alpha 5 integrin gene generated by gene targeting in embryonic stem cells is a recessive embryonic lethal. The mutant embryos start to show observable defects by day 9 of gestation and die around day 10-11. The alpha 5-null embryos have pronounced defects in posterior trunk and yolk sac mesodermal structures, suggesting a role for alpha 5 beta 1 integrin in mesoderm formation, movement or function. However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors. In vitro studies on cells derived from the alpha 5-null embryos confirm that the alpha 5 beta 1 integrin is not expressed on mutant cells and show that the mutant cells are able to assemble fibronectin matrix, form focal contacts, and migrate on fibronectin despite the complete absence of the alpha 5 beta 1 fibronectin receptor integrin. All these functions have previously been thought to involve or require alpha 5 beta 1. The results presented show that these cellular functions involving fibronectin can proceed using other receptors.
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Cancer Res., July 1, 2001; 61(13): 5255 - 5261.
[Abstract] [Full Text] [PDF]


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J. Physiol.Home page
M. H Wu, E. Ustinova, and H. J Granger
Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules
J. Physiol., May 1, 2001; 532(3): 785 - 791.
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DevelopmentHome page
M Mahlapuu, M Ormestad, S Enerback, and P Carlsson
The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
Development, January 1, 2001; 128(2): 155 - 166.
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Am. J. Physiol. Heart Circ. Physiol.Home page
M. L. Valencik and J. A. McDonald
Cardiac expression of a gain-of-function {alpha}5-integrin results in perinatal lethality
Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H361 - H367.
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J. Am. Soc. Nephrol.Home page
L. J. AREND, A. M. SMART, and J. P. BRIGGS
Mouse {beta}6 Integrin Sequence, Pattern of Expression, and Role in Kidney Development
J. Am. Soc. Nephrol., December 1, 2000; 11(12): 2297 - 2305.
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Hum Mol GenetHome page
V. Allamand and K. P. Campbell
Animal models for muscular dystrophy: valuable tools for the development of therapies
Hum. Mol. Genet., October 1, 2000; 9(16): 2459 - 2467.
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Circ. Res.Home page
L. K. Hornberger, S. Singhroy, T. Cavalle-Garrido, W. Tsang, F. Keeley, and M. Rabinovitch
Synthesis of Extracellular Matrix and Adhesion Through {beta}1 Integrins Are Critical for Fetal Ventricular Myocyte Proliferation
Circ. Res., September 15, 2000; 87(6): 508 - 515.
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Cardiovasc ResHome page
J. Hescheler and B. K. Fleischmann
Integrins and cell structure: powerful determinants of heart development and heart function
Cardiovasc Res, September 1, 2000; 47(4): 645 - 647.
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Exp. Biol. Med.Home page
J. A. Bowen and J. S. Hunt
The Role of Integrins in Reproduction
Experimental Biology and Medicine, April 1, 2000; 223(4): 331 - 343.
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Am. J. Pathol.Home page
S. Kim, K. Bell, S. A. Mousa, and J. A. Varner
Regulation of Angiogenesis in Vivo by Ligation of Integrin {alpha}5{beta}1 with the Central Cell-Binding Domain of Fibronectin
Am. J. Pathol., April 1, 2000; 156(4): 1345 - 1362.
[Abstract] [Full Text] [PDF]


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JCBHome page
R. Pankov, E. Cukierman, B.-Z. Katz, K. Matsumoto, D. C. Lin, S. Lin, C. Hahn, and K. M. Yamada
Integrin Dynamics and Matrix Assembly: Tensin-dependent Translocation of {alpha}5{beta}1 Integrins Promotes Early Fibronectin Fibrillogenesis
J. Cell Biol., March 6, 2000; 148(5): 1075 - 1090.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
Genes & Dev., July 15, 1999; 13(14): 1834 - 1846.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
Y.-F. Liao, K. G. Wieder, J. M. Classen, and L. V. De Water
Identification of Two Amino Acids within the EIIIA (ED-A) Segment of Fibronectin Constituting the Epitope for Two Function-blocking Monoclonal Antibodies
J. Biol. Chem., June 18, 1999; 274(25): 17876 - 17884.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
A. Gohla, S. Offermanns, T. M. Wilkie, and G. Schultz
Differential Involvement of Galpha 12 and Galpha 13 in Receptor-mediated Stress Fiber Formation
J. Biol. Chem., June 18, 1999; 274(25): 17901 - 17907.
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J. Neurosci.Home page
J. K. Pinkstaff, J. Detterich, G. Lynch, and C. Gall
Integrin Subunit Gene Expression Is Regionally Differentiated in Adult Brain
J. Neurosci., March 1, 1999; 19(5): 1541 - 1556.
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J. Cell Sci.Home page
S Testaz, M Delannet, and J Duband
Adhesion and migration of avian neural crest cells on fibronectin require the cooperating activities of multiple integrins of the (beta)1 and (beta)3 families
J. Cell Sci., January 12, 1999; 112(24): 4715 - 4728.
[Abstract] [PDF]


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DevelopmentHome page
C Coffinier, D Thepot, C Babinet, M Yaniv, and J Barra
Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
Development, January 11, 1999; 126(21): 4785 - 4794.
[Abstract] [PDF]


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DevelopmentHome page
A De Arcangelis, M Mark, J Kreidberg, L Sorokin, and E Georges-Labouesse
Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
Development, January 9, 1999; 126(17): 3957 - 3968.
[Abstract] [PDF]


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DevelopmentHome page
M. Goumans, A Zwijsen, M. van Rooijen, D Huylebroeck, B. Roelen, and C. Mummery
Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
Development, January 8, 1999; 126(16): 3473 - 3483.
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J. Cell Sci.Home page
H Gardner, A Broberg, A Pozzi, M Laato, and J Heino
Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis
J. Cell Sci., January 2, 1999; 112(3): 263 - 272.
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J. Cell Sci.Home page
G Collo and M. Pepper
Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro
J. Cell Sci., January 2, 1999; 112(4): 569 - 578.
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DevelopmentHome page
L Pardanaud and F Dieterlen-Lievre
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo
Development, January 2, 1999; 126(4): 617 - 627.
[Abstract] [PDF]


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J. Biol. Chem.Home page
Q. Zhang, T. Sakai, J. Nowlen, I. Hayashi, R. Fassler, and D. F. Mosher
Functional beta 1-Integrins Release the Suppression of Fibronectin Matrix Assembly by Vitronectin
J. Biol. Chem., January 1, 1999; 274(1): 368 - 375.
[Abstract] [Full Text] [PDF]


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JCBHome page
D. Taverna, M.-H. Disatnik, H. Rayburn, R. T. Bronson, J. Yang, T. A. Rando, and R. O. Hynes
Dystrophic Muscle in Mice Chimeric for Expression of alpha 5 Integrin
J. Cell Biol., November 2, 1998; 143(3): 849 - 859.
[Abstract] [Full Text] [PDF]


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JCBHome page
S. Bourdoulous, G. Orend, D. A. MacKenna, R. Pasqualini, and E. Ruoslahti
Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression
J. Cell Biol., October 5, 1998; 143(1): 267 - 276.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Cell Mol. Bio.Home page
D. Sheppard
Airway Epithelial Integrins: Why So Many?
Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 349 - 351.
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Arterioscler. Thromb. Vasc. Bio.Home page
M. K. Magnusson and D. F. Mosher
Fibronectin : Structure, Assembly, and Cardiovascular Implications
Arterioscler. Thromb. Vasc. Biol., September 1, 1998; 18(9): 1363 - 1370.
[Full Text] [PDF]


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Mol. Biol. CellHome page
S. Denda, L. F. Reichardt, and U. Müller
Identification of Osteopontin as a Novel Ligand for the Integrin alpha 8beta 1 and Potential Roles for This Integrin-Ligand Interaction in Kidney Morphogenesis
Mol. Biol. Cell, June 1, 1998; 9(6): 1425 - 1435.
[Abstract] [Full Text]


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BloodHome page
T. Yokota, K. Oritani, H. Mitsui, K. Aoyama, J. Ishikawa, H. Sugahara, I. Matsumura, S. Tsai, Y. Tomiyama, Y. Kanakura, et al.
Growth-Supporting Activities of Fibronectin on Hematopoietic Stem/Progenitor Cells In Vitro and In Vivo: Structural Requirement for Fibronectin Activities of CS1 and Cell-Binding Domains
Blood, May 1, 1998; 91(9): 3263 - 3272.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
C. Baudoin, M.-J. Goumans, C. Mummery, and A. Sonnenberg
Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development
Genes & Dev., April 15, 1998; 12(8): 1202 - 1216.
[Abstract] [Full Text]


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DevelopmentHome page
A. Hatzopoulos, J Folkman, E Vasile, G. Eiselen, and R. Rosenberg
Isolation and characterization of endothelial progenitor cells from mouse embryos
Development, January 4, 1998; 125(8): 1457 - 1468.
[Abstract] [PDF]


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J. Biol. Chem.Home page
C. Wu, S. Y. Keightley, C. Leung-Hagesteijn, G. Radeva, M. Coppolino, S. Goicoechea, J. A. McDonald, and S. Dedhar
Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity
J. Biol. Chem., January 2, 1998; 273(1): 528 - 536.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
J. L. Sechler, S. A. Corbett, and J. E. Schwarzbauer
Modulatory Roles for Integrin Activation and the Synergy Site of Fibronectin during Matrix Assembly
Mol. Biol. Cell, December 1, 1997; 8(12): 2563 - 2573.
[Abstract] [Full Text]


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Mol. Biol. CellHome page
C. Pujades, R. Alon, R. L. Yauch, A. Masumoto, L. C. Burkly, C. Chen, T. A. Springer, R. R. Lobb, and M. E. Hemler
Defining Extracellular Integrin alpha -Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding
Mol. Biol. Cell, December 1, 1997; 8(12): 2647 - 2657.
[Abstract] [Full Text]




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