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Development, Vol 119, Issue 4 1093-1105, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
JT Yang, H Rayburn and RO Hynes
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.
A loss of function mutation of the murine alpha 5 integrin gene generated by gene targeting in embryonic stem cells is a recessive embryonic lethal. The mutant embryos start to show observable defects by day 9 of gestation and die around day 10-11. The alpha 5-null embryos have pronounced defects in posterior trunk and yolk sac mesodermal structures, suggesting a role for alpha 5 beta 1 integrin in mesoderm formation, movement or function. However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors. In vitro studies on cells derived from the alpha 5-null embryos confirm that the alpha 5 beta 1 integrin is not expressed on mutant cells and show that the mutant cells are able to assemble fibronectin matrix, form focal contacts, and migrate on fibronectin despite the complete absence of the alpha 5 beta 1 fibronectin receptor integrin. All these functions have previously been thought to involve or require alpha 5 beta 1. The results presented show that these cellular functions involving fibronectin can proceed using other receptors.
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J. Hescheler and B. K. Fleischmann Integrins and cell structure: powerful determinants of heart development and heart function Cardiovasc Res, September 1, 2000; 47(4): 645 - 647. [Full Text] [PDF]
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 J. A. Bowen and J. S. Hunt The Role of Integrins in Reproduction Experimental Biology and Medicine, April 1, 2000; 223(4): 331 - 343. [Abstract] [Full Text] [PDF]
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S. Kim, K. Bell, S. A. Mousa, and J. A. Varner Regulation of Angiogenesis in Vivo by Ligation of Integrin {alpha}5{beta}1 with the Central Cell-Binding Domain of Fibronectin Am. J. Pathol., April 1, 2000; 156(4): 1345 - 1362. [Abstract] [Full Text] [PDF]
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R. Pankov, E. Cukierman, B.-Z. Katz, K. Matsumoto, D. C. Lin, S. Lin, C. Hahn, and K. M. Yamada Integrin Dynamics and Matrix Assembly: Tensin-dependent Translocation of {alpha}5{beta}1 Integrins Promotes Early Fibronectin Fibrillogenesis J. Cell Biol., March 6, 2000; 148(5): 1075 - 1090. [Abstract] [Full Text] [PDF]
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X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo Genes & Dev., July 15, 1999; 13(14): 1834 - 1846. [Abstract] [Full Text]
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Y.-F. Liao, K. G. Wieder, J. M. Classen, and L. V. De Water Identification of Two Amino Acids within the EIIIA (ED-A) Segment of Fibronectin Constituting the Epitope for Two Function-blocking Monoclonal Antibodies J. Biol. Chem., June 18, 1999; 274(25): 17876 - 17884. [Abstract] [Full Text] [PDF]
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A. Gohla, S. Offermanns, T. M. Wilkie, and G. Schultz Differential Involvement of Galpha 12 and Galpha 13 in Receptor-mediated Stress Fiber Formation J. Biol. Chem., June 18, 1999; 274(25): 17901 - 17907. [Abstract] [Full Text] [PDF]
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 J. K. Pinkstaff, J. Detterich, G. Lynch, and C. Gall Integrin Subunit Gene Expression Is Regionally Differentiated in Adult Brain J. Neurosci., March 1, 1999; 19(5): 1541 - 1556. [Abstract] [Full Text] [PDF]
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S Testaz, M Delannet, and J Duband Adhesion and migration of avian neural crest cells on fibronectin require the cooperating activities of multiple integrins of the (beta)1 and (beta)3 families J. Cell Sci., January 12, 1999; 112(24): 4715 - 4728. [Abstract] [PDF]
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C Coffinier, D Thepot, C Babinet, M Yaniv, and J Barra Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation Development, January 11, 1999; 126(21): 4785 - 4794. [Abstract] [PDF]
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A De Arcangelis, M Mark, J Kreidberg, L Sorokin, and E Georges-Labouesse Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse Development, January 9, 1999; 126(17): 3957 - 3968. [Abstract] [PDF]
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M. Goumans, A Zwijsen, M. van Rooijen, D Huylebroeck, B. Roelen, and C. Mummery Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice Development, January 8, 1999; 126(16): 3473 - 3483. [Abstract] [PDF]
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H Gardner, A Broberg, A Pozzi, M Laato, and J Heino Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis J. Cell Sci., January 2, 1999; 112(3): 263 - 272. [Abstract] [PDF]
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G Collo and M. Pepper Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro J. Cell Sci., January 2, 1999; 112(4): 569 - 578. [Abstract] [PDF]
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L Pardanaud and F Dieterlen-Lievre Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo Development, January 2, 1999; 126(4): 617 - 627. [Abstract] [PDF]
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Q. Zhang, T. Sakai, J. Nowlen, I. Hayashi, R. Fassler, and D. F. Mosher Functional beta 1-Integrins Release the Suppression of Fibronectin Matrix Assembly by Vitronectin J. Biol. Chem., January 1, 1999; 274(1): 368 - 375. [Abstract] [Full Text] [PDF]
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D. Taverna, M.-H. Disatnik, H. Rayburn, R. T. Bronson, J. Yang, T. A. Rando, and R. O. Hynes Dystrophic Muscle in Mice Chimeric for Expression of alpha 5 Integrin J. Cell Biol., November 2, 1998; 143(3): 849 - 859. [Abstract] [Full Text] [PDF]
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S. Bourdoulous, G. Orend, D. A. MacKenna, R. Pasqualini, and E. Ruoslahti Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression J. Cell Biol., October 5, 1998; 143(1): 267 - 276. [Abstract] [Full Text] [PDF]
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 D. Sheppard Airway Epithelial Integrins: Why So Many? Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 349 - 351. [Full Text]
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M. K. Magnusson and D. F. Mosher Fibronectin : Structure, Assembly, and Cardiovascular Implications Arterioscler. Thromb. Vasc. Biol., September 1, 1998; 18(9): 1363 - 1370. [Full Text] [PDF]
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S. Denda, L. F. Reichardt, and U. Müller Identification of Osteopontin as a Novel Ligand for the Integrin alpha 8beta 1 and Potential Roles for This Integrin-Ligand Interaction in Kidney Morphogenesis Mol. Biol. Cell, June 1, 1998; 9(6): 1425 - 1435. [Abstract] [Full Text]
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T. Yokota, K. Oritani, H. Mitsui, K. Aoyama, J. Ishikawa, H. Sugahara, I. Matsumura, S. Tsai, Y. Tomiyama, Y. Kanakura, et al. Growth-Supporting Activities of Fibronectin on Hematopoietic Stem/Progenitor Cells In Vitro and In Vivo: Structural Requirement for Fibronectin Activities of CS1 and Cell-Binding Domains Blood, May 1, 1998; 91(9): 3263 - 3272. [Abstract] [Full Text] [PDF]
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C. Baudoin, M.-J. Goumans, C. Mummery, and A. Sonnenberg Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development Genes & Dev., April 15, 1998; 12(8): 1202 - 1216. [Abstract] [Full Text]
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A. Hatzopoulos, J Folkman, E Vasile, G. Eiselen, and R. Rosenberg Isolation and characterization of endothelial progenitor cells from mouse embryos Development, January 4, 1998; 125(8): 1457 - 1468. [Abstract] [PDF]
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C. Wu, S. Y. Keightley, C. Leung-Hagesteijn, G. Radeva, M. Coppolino, S. Goicoechea, J. A. McDonald, and S. Dedhar Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity J. Biol. Chem., January 2, 1998; 273(1): 528 - 536. [Abstract] [Full Text] [PDF]
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J. L. Sechler, S. A. Corbett, and J. E. Schwarzbauer Modulatory Roles for Integrin Activation and the Synergy Site of Fibronectin during Matrix Assembly Mol. Biol. Cell, December 1, 1997; 8(12): 2563 - 2573. [Abstract] [Full Text]
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C. Pujades, R. Alon, R. L. Yauch, A. Masumoto, L. C. Burkly, C. Chen, T. A. Springer, R. R. Lobb, and M. E. Hemler Defining Extracellular Integrin alpha -Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding Mol. Biol. Cell, December 1, 1997; 8(12): 2647 - 2657. [Abstract] [Full Text]
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