|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 4 1229-1236, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
F Poirier and EJ Robertson
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
The L14 lectin is a 14 x 10(3) M(r) carbohydrate binding protein belonging to the family of S-type lectins. The pattern of expression of this protein during mouse embryogenesis suggests that it may have multiple roles during pre- and post-implantation development. Using the technique of homologous recombination in embryonic stem cells, we have introduced a null mutation in the gene encoding the L14 lectin and generated a strain of mice carrying the mutant allele. We report here that homozygous mutant animals that lack the L14 lectin develop normally and are viable and fertile. The absence of any major phenotypic abnormalities in these mutant animals suggests that other protein(s) potentially compensate for the absence of the L14 lectin. Here we show that a related protein termed L30, a lectin that has carbohydrate binding specificity similar to that of L14, is present in the same embryonic cell populations as L14 at the time of implantation, suggesting that the two S-type lectins may be capable of functional substitution at this early stage of embryogenesis.
This article has been cited by other articles:
|
|
 |
|
  H. D. Kopcow, F. Rosetti, Y. Leung, D. S. J. Allan, J. L. Kutok, and J. L. Strominger T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1 PNAS, November 25, 2008; 105(47): 18472 - 18477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Liu, C. C. Whiting, T. Tomassian, M. Pang, S. J. Bissel, L. G. Baum, V. V. Mossine, F. Poirier, M. E. Huflejt, and M. C. Miceli Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes Blood, July 1, 2008; 112(1): 120 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Norling, A. L. F. Sampaio, D. Cooper, and M. Perretti Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking FASEB J, March 1, 2008; 22(3): 682 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Garin, C.-C. Chu, D. Golshayan, E. Cernuda-Morollon, R. Wait, and R. I. Lechler Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells Blood, March 1, 2007; 109(5): 2058 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Barrionuevo, M. Beigier-Bompadre, J. M. Ilarregui, M. A. Toscano, G. A. Bianco, M. A. Isturiz, and G. A. Rabinovich A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage Physiology through a Nonapoptotic ERK-Dependent Pathway J. Immunol., January 1, 2007; 178(1): 436 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Case, D. Irwin, C. Ivester, J. Harral, K. Morris, M. Imamura, M. Roedersheimer, A. Patterson, M. Carr, M. Hagen, et al. Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L154 - L164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Foster, K. L. Goss, C. L. S. George, P. J. Bangsund, and J. M. Snyder Galectin-1 in secondary alveolar septae of neonatal mouse lung Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1142 - L1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Camby, M. Le Mercier, F. Lefranc, and R. Kiss Galectin-1: a small protein with major functions Glycobiology, November 1, 2006; 16(11): 137R - 157R. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. J. L. Thijssen, R. Postel, R. J. M. G. E. Brandwijk, R. P. M. Dings, I. Nesmelova, S. Satijn, N. Verhofstad, Y. Nakabeppu, L. G. Baum, J. Bakkers, et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy PNAS, October 24, 2006; 103(43): 15975 - 15980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sakaguchi, T. Shingo, T. Shimazaki, H. J. Okano, M. Shiwa, S. Ishibashi, H. Oguro, M. Ninomiya, T. Kadoya, H. Horie, et al. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells PNAS, May 2, 2006; 103(18): 7112 - 7117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nio, Y. Kon, and T. Iwanaga Differential Cellular Expression of Galectin Family mRNAs in the Epithelial Cells of the Mouse Digestive Tract J. Histochem. Cytochem., November 1, 2005; 53(11): 1323 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Houzelstein, I. R. Goncalves, A. J. Fadden, S. S. Sidhu, D. N. W. Cooper, K. Drickamer, H. Leffler, and F. Poirier Phylogenetic Analysis of the Vertebrate Galectin Family Mol. Biol. Evol., July 1, 2004; 21(7): 1177 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Carlow, M. J. Williams, and H. J. Ziltener Modulation of O-Glycans and N-Glycans on Murine CD8 T Cells Fails to Alter Annexin V Ligand Induction by Galectin 1 J. Immunol., November 15, 2003; 171(10): 5100 - 5106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dias-Baruffi, H. Zhu, M. Cho, S. Karmakar, R. P. McEver, and R. D. Cummings Dimeric Galectin-1 Induces Surface Exposure of Phosphatidylserine and Phagocytic Recognition of Leukocytes without Inducing Apoptosis J. Biol. Chem., October 17, 2003; 278(42): 41282 - 41293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. La, T. V. Cao, G. Cerchiaro, K. Chilton, J. Hirabayashi, K.-i. Kasai, S. M. Oliani, Y. Chernajovsky, and M. Perretti A Novel Biological Activity for Galectin-1: Inhibition of Leukocyte-Endothelial Cell Interactions in Experimental Inflammation Am. J. Pathol., October 1, 2003; 163(4): 1505 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dettin, N. Rubinstein, A. Aoki, G. A. Rabinovich, and C. A. Maldonado Regulated Expression and Ultrastructural Localization of Galectin-1, a Proapoptotic {beta}-Galactoside-Binding Lectin, During Spermatogenesis in Rat Testis Biol Reprod, January 1, 2003; 68(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-Q. Zhao, Z.-M. Sheng, M. M. Tsai, A. E. Hubbs, R. Wang, T. J. O'Leary, D. J. Izon, and J. K. Taubenberger Serial analysis of gene expression in murine fetal thymocyte cell lines Int. Immunol., December 1, 2002; 14(12): 1383 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Cao, N. Said, S. Amin, H. K. Wu, A. Bruce, M. Garate, D. K. Hsu, I. Kuwabara, F.-T. Liu, and N. Panjwani Galectins-3 and -7, but not Galectin-1, Play a Role in Re-epithelialization of Wounds J. Biol. Chem., October 25, 2002; 277(44): 42299 - 42305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Hernandez and L. G. Baum Ah, sweet mystery of death! Galectins and control of cell fate Glycobiology, October 1, 2002; 12(10): 127R - 136R. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gauthier, B. Rossi, F. Roux, E. Termine, and C. Schiff Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering PNAS, October 1, 2002; 99(20): 13014 - 13019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Christopher, T. F. Mueller, C. Ma, Y. Liang, and D. L. Perkins Analysis of the Innate and Adaptive Phases of Allograft Rejection by Cluster Analysis of Transcriptional Profiles J. Immunol., July 1, 2002; 169(1): 522 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Davidson, M. J. Davis, R. J. Patterson, M.-A. Ripoche, F. Poirier, and J. L. Wang Shuttling of galectin-3 between the nucleus and cytoplasm Glycobiology, May 1, 2002; 12(5): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Timmons, P. W. J. Rigby, and F. Poirier The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis Development, January 2, 2002; 129(3): 635 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Chung, V. P. Patel, M. Moran, L. A. Lewis, and M. C. Miceli Galectin-1 Induces Partial TCR {zeta}-Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction J. Immunol., October 1, 2000; 165(7): 3722 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Rabinovich, G. Daly, H. Dreja, H. Tailor, C. M. Riera, J. Hirabayashi, and Y. Chernajovsky Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-induced Arthritis via T Cell Apoptosis J. Exp. Med., August 2, 1999; 190(3): 385 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. R. Vespa, L. A. Lewis, K. R. Kozak, M. Moran, J. T. Nguyen, L. G. Baum, and M. C. Miceli Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation J. Immunol., January 15, 1999; 162(2): 799 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Rabinovich, M. M. Iglesias, N. M. Modesti, L. F. Castagna, C. Wolfenstein-Todel, C. M. Riera, and C. E. Sotomayor Activated Rat Macrophages Produce a Galectin-1-Like Protein That Induces Apoptosis of T Cells: Biochemical and Functional Characterization J. Immunol., May 15, 1998; 160(10): 4831 - 4840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Choi, A. van Wijnen, F Aslam, J. Leszyk, J. Stein, G. Stein, J. Lian, and S Penman Developmental association of the beta-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts J. Cell Sci., January 10, 1998; 111(20): 3035 - 3043. [Abstract] [PDF]
|
|
|
|
|
|
N. L. Perillo, C. H. Uittenbogaart, J. T. Nguyen, and L. G. Baum Galectin-1, an Endogenous Lectin Produced by Thymic Epithelial Cells, Induces Apoptosis of Human Thymocytes J. Exp. Med., May 19, 1997; 185(10): 1851 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wasano and Y. Hirakawa Recombinant Galectin-1 Recognizes Mucin and Epithelial Cell Surface Glycocalyces of Gastrointestinal Tract J. Histochem. Cytochem., February 1, 1997; 45(2): 275 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hirabayashi, T. Ubukata, and K.-i. Kasai Purification and Molecular Characterization of a Novel 16-kDa Galectin from the Nematode Caenorhabditis elegans J. Biol. Chem., February 2, 1996; 271(5): 2497 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A T Dudley, K M Lyons, and E J Robertson A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes & Dev., November 15, 1995; 9(22): 2795 - 2807. [Abstract] [PDF]
|
|
