|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 4 1317-1328, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
D Altshuler, JJ Lo Turco, J Rush and C Cepko
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
The retina offers a model system for investigating the mechanisms that control cell type determination and differentiation in the vertebrate central nervous system. Previously, rod photoreceptor development in vitro was found to require a diffusible activity released by retinal cells (D. Altshuler and C. Cepko, Development 114, 947-957, 1992). In this report, we show that retinal-cell-conditioned medium and extracts contain two separable activities that influence rod development: a > 10 kDa inhibitory activity, and a stimulatory activity that is < 1 kDa and heat stable. Taurine was found to be a component of the < 1 kDa fraction and to stimulate rod development when added to retinal cultures. Taurine was not the only rod-promoting factor in these retinal preparations, however, as conditioned medium and extracts stimulated a higher level of rod development than did taurine alone. Taurine uptake into cells could be blocked without inhibiting taurine's ability to stimulate rod development, arguing against an osmoregulatory or nutritive mechanism of action. Finally, a competitive antagonist of taurine's bioactivity was identified and shown partially to inhibit rod development in retinal explants, suggesting that taurine may normally act to stimulate rod development in the retina. These results provide evidence for three activities, one of which is taurine, that are candidate regulators of rod photoreceptor development in vivo.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. J. Bailey, S. L. Coon, D. A. Carter, A. Humphries, J.-s. Kim, Q. Shi, P. Gaildrat, F. Morin, S. Ganguly, J. B. Hogenesch, et al. Night/Day Changes in Pineal Expression of >600 Genes: CENTRAL ROLE OF ADRENERGIC/cAMP SIGNALING J. Biol. Chem., March 20, 2009; 284(12): 7606 - 7622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Kilb, I. L. Hanganu, A. Okabe, B. A. Sava, C. Shimizu-Okabe, A. Fukuda, and H. J. Luhmann Glycine Receptors Mediate Excitation of Subplate Neurons in Neonatal Rat Cerebral Cortex J Neurophysiol, August 1, 2008; 100(2): 698 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Khanna, M. Akimoto, S. Siffroi-Fernandez, J. S. Friedman, D. Hicks, and A. Swaroop Retinoic Acid Regulates the Expression of Photoreceptor Transcription Factor NRL J. Biol. Chem., September 15, 2006; 281(37): 27327 - 27334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Checchin, F. Sennlaub, E. Levavasseur, M. Leduc, and S. Chemtob Potential role of microglia in retinal blood vessel formation. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3595 - 3602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Garelli, N. P. Rotstein, and L. E. Politi Docosahexaenoic Acid Promotes Photoreceptor Differentiation without Altering Crx Expression. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 3017 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ooto, T. Akagi, R. Kageyama, J. Akita, M. Mandai, Y. Honda, and M. Takahashi Potential for neural regeneration after neurotoxic injury in the adult mammalian retina PNAS, September 14, 2004; 101(37): 13654 - 13659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brownlee Inaugural Article: Biography of Constance L. Cepko PNAS, January 6, 2004; 101(1): 14 - 15. [Full Text] [PDF]
|
|
|
|
|
|
R.-T. Yan and S.-Z. Wang Requirement of NeuroD for Photoreceptor Formation in the Chick Retina Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 48 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. James, A. V. Das, S. Bhattacharya, D. M. Chacko, X. Zhao, and I. Ahmad In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors J. Neurosci., September 10, 2003; 23(23): 8193 - 8203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kicic, W.-Y. Shen, A. S. Wilson, I. J. Constable, T. Robertson, and P. E. Rakoczy Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye J. Neurosci., August 27, 2003; 23(21): 7742 - 7749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schulz-Key, H.-D. Hofmann, C. Beisenherz-Huss, C. Barbisch, and M. Kirsch Ciliary Neurotrophic Factor as a Transient Negative Regulator of Rod Development in Rat Retina Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 3099 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang and X. Yang Regulation of retinal ganglion cell production by Sonic hedgehog Development, January 3, 2001; 128(6): 943 - 957. [Abstract] [PDF]
|
|
|
|
|
|
H.-Q. Xie and R. Adler Green Cone Opsin and Rhodopsin Regulation by CNTF and Staurosporine in Cultured Chick Photoreceptors Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4317 - 4323. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Link, J. M. Fadool, J. Malicki, and J. E. Dowling The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells Development, May 15, 2000; 127(10): 2177 - 2188. [Abstract] [PDF]
|
|
|
|
|
|
P. Steullet, H. S. Cate, and C. D. Derby A Spatiotemporal Wave of Turnover and Functional Maturation of Olfactory Receptor Neurons in the Spiny Lobster Panulirus argus J. Neurosci., May 1, 2000; 20(9): 3282 - 3294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Belliveau, T. L. Young, and C. L. Cepko Late Retinal Progenitor Cells Show Intrinsic Limitations in the Production of Cell Types and the Kinetics of Opsin Synthesis J. Neurosci., March 15, 2000; 20(6): 2247 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rohrer, J. I. Korenbrot, M. M. LaVail, L. F. Reichardt, and B. Xu Role of Neurotrophin Receptor TrkB in the Maturation of Rod Photoreceptors and Establishment of Synaptic Transmission to the Inner Retina J. Neurosci., October 15, 1999; 19(20): 8919 - 8930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Belliveau and C. Cepko Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina Development, January 2, 1999; 126(3): 555 - 566. [Abstract] [PDF]
|
|
|
|
|
|
V. Fontaine, N. Kinkl, J. Sahel, H. Dreyfus, and D. Hicks Survival of Purified Rat Photoreceptors In Vitro Is Stimulated Directly by Fibroblast Growth Factor-2 J. Neurosci., December 1, 1998; 18(23): 9662 - 9672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Norrander, M. Larsson, S. Stahl, C. Hoog, and R. Linck Expression of Ciliary Tektins in Brain and Sensory Development J. Neurosci., November 1, 1998; 18(21): 8912 - 8918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Morrow, M. J. Belliveau, and C. L. Cepko Two Phases of Rod Photoreceptor Differentiation during Rat Retinal Development J. Neurosci., May 15, 1998; 18(10): 3738 - 3748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Hyer, T Mima, and T Mikawa FGF1 patterns the optic vesicle by directing the placement of the neural retina domain Development, January 3, 1998; 125(5): 869 - 877. [Abstract] [PDF]
|
|
|
|
|
|
D. Waid and S. McLoon Ganglion cells influence the fate of dividing retinal cells in culture Development, January 3, 1998; 125(6): 1059 - 1066. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Levine, H. Roelink, J. Turner, and T. A. Reh Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro J. Neurosci., August 15, 1997; 17(16): 6277 - 6288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Neophytou, A. Vernallis, A Smith, and M. Raff Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development Development, January 6, 1997; 124(12): 2345 - 2354. [Abstract] [PDF]
|
|
|
|
|
|
Z. Ezzeddine, X Yang, T DeChiara, G Yancopoulos, and C. Cepko Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina Development, January 3, 1997; 124(5): 1055 - 1067. [Abstract] [PDF]
|
|
|
|
|
|
M. Alexiades and C. Cepko Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny Development, January 3, 1997; 124(6): 1119 - 1131. [Abstract] [PDF]
|
|
|
|
|
|
A. Bohner, R. Akers, and S. McConnell Induction of deep layer cortical neurons in vitro Development, January 2, 1997; 124(4): 915 - 923. [Abstract] [PDF]
|
|
|
|
|
|
G. A. Hyatt, E. A. Schmitt, J. M. Fadool, and J. E. Dowling Retinoic acid alters photoreceptor development in vivo PNAS, November 12, 1996; 93(23): 13298 - 13303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Malicki, S. Neuhauss, A. Schier, L Solnica-Krezel, D. Stemple, D. Stainier, S Abdelilah, F Zwartkruis, Z Rangini, and W Driever Mutations affecting development of the zebrafish retina Development, January 12, 1996; 123(1): 263 - 273. [Abstract] [PDF]
|
|
|
|
|
|
C. Austin, D. Feldman, J. Ida, and C. Cepko Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch Development, January 11, 1995; 121(11): 3637 - 3650. [Abstract] [PDF]
|
|
|
|
|
|
M. Kelley, J. Turner, and T. Reh Ligands of steroid/thyroid receptors induce cone photoreceptors in vertebrate retina Development, January 11, 1995; 121(11): 3777 - 3785. [Abstract] [PDF]
|
|
|
|
|
|
S Fuhrmann, M Kirsch, and H. Hofmann Ciliary neurotrophic factor promotes chick photoreceptor development in vitro Development, January 8, 1995; 121(8): 2695 - 2706. [Abstract] [PDF]
|
|
|
|
|
|
R. Ferri and P Levitt Regulation of regional differences in the differentiation of cerebral cortical neurons by EGF family-matrix interactions Development, January 4, 1995; 121(4): 1151 - 1160. [Abstract] [PDF]
|
|
|
|
|
|
M. Kelley, J. Turner, and T. Reh Retinoic acid promotes differentiation of photoreceptors in vitro Development, January 8, 1994; 120(8): 2091 - 2102. [Abstract] [PDF]
|
|
