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Development, Vol 120, Issue 10 3033-3042, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
M Gonzalez-Garcia, R Perez-Ballestero, L Ding, L Duan, LH Boise, CB Thompson and G Nunez
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.
Most examples of cell death in animals are controlled by a genetic program that is activated within the dying cell. The apoptotic process is further regulated by a set of genes that act as repressors of cell death. Of these, bcl-2 is expressed in a variety of embryonic and postnatal tissues which suggests a critical role for bcl-2 in organogenesis and tissue homeostasis. Surprisingly, mutant mice with targeted disruption of bcl-2 appear normal at birth and complete maturation of lymphoid tissues before succumbing to fulminant lymphopenia and polycystic renal disease by 2-5 weeks of age. This suggests that there may be genes other than bcl-2 that can regulate apoptosis during development. To begin to investigate this possibility, we have cloned and characterized the murine bcl-x gene, whose human counterpart displays striking homology to bcl-2. The predicted murine bcl-xL gene product exhibits a high level of amino acid identity (97%) to its human counterpart. Just like Bcl-2, the murine bcl-xL gene product can act as a dominant inhibitor of cell death upon growth factor withdrawal. In addition, the bulk of the bcl-xL product localizes to the periphery of mitochondria as assessed by a bcl-xL-tag expression system, suggesting that both Bcl-2 and Bcl-xL proteins prevent cell death by a similar mechanism. bcl-xL is the most abundant bcl-x mRNA species expressed in embryonic and adult tissues. The levels of bcl-xL mRNA appear higher than those of bcl-2 during embryonal development and in several adult organs including bone marrow, brain, kidney and thymus. In addition to bcl-xL, we have identified another form of bcl-x mRNA, bcl-x beta, that results from an unspliced bcl-x transcript. bcl-x beta mRNA is expressed in various embryonic and postnatal tissues. Surprisingly, the expression of bcl-xS (a negative regulator of programmed cell death) was undetectable by a sensitive S1-nuclease assay and polymerase chain reaction analysis of mouse tissues. Based on its tissue and developmental patterns of expression, it appears that bcl-x may play an important role in the regulation of cell death during development and tissue homeostasis.
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|
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|
|
|
|
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|
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|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
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|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
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|
|
|
|
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|
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|
|
 |
|
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|
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|
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L. Sevilla, C. Aperlo, V. Dulic, J. C. Chambard, C. Boutonnet, O. Pasquier, P. Pognonec, and K. E. Boulukos The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-xL-Dependent Mechanism Mol. Cell. Biol., April 1, 1999; 19(4): 2624 - 2634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
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T.-C. Wen, J. Tanaka, H. Peng, J. Desaki, S. Matsuda, N. Maeda, H. Fujita, K. Sato, and M. Sakanaka Interleukin 3 Prevents Delayed Neuronal Death in the Hippocampal CA1 Field J. Exp. Med., August 17, 1998; 188(4): 635 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
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|
N. Inohara, D. Ekhterae, I. Garcia, R. Carrio, J. Merino, A. Merry, S. Chen, and G. Nunez Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL J. Biol. Chem., April 10, 1998; 273(15): 8705 - 8710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Okada, H. Zhang, M. Hatano, and T. Tokuhisa A Physiologic Role of Bcl-xL Induced in Activated Macrophages J. Immunol., March 15, 1998; 160(6): 2590 - 2596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Blomer, T. Kafri, L. Randolph-Moore, I. M. Verma, and F. H. Gage Bcl-xL protects adult septal cholinergic neurons from axotomized cell death PNAS, March 3, 1998; 95(5): 2603 - 2608. [Abstract] [Full Text] [PDF]
|
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|
 |
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 L. Ramamoorthy and I. R. Tizard Induction of Apoptosis in a Macrophage Cell Line RAW 264.7 By Acemannan, a beta -(1,4)-Acetylated Mannan Mol. |
