|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 11 3105-3117, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
M Affolter, D Nellen, U Nussbaumer and K Basler
Biozentrum, Universitat Basel, Switzerland.
Differentiation of distinct cell types at specific locations within a developing organism depends largely on the ability of cells to communicate. A major class of signalling proteins implicated in cell to cell communication is represented by members of the TGF beta superfamily. A corresponding class of transmembrane serine/threonine kinases has recently been discovered that act as cell surface receptors for ligands of the TGF beta superfamily. The product of the Drosophila gene decapentaplegic (dpp) encodes a TGF beta homolog that plays multiple roles during embryogenesis and the development of imaginal discs. Here we describe the complex expression pattern of thick veins (tkv), which encodes a receptor for dpp. We make use of tkv loss-of-function mutations to examine the consequences of the failure of embryonic cells to respond to dpp and/or other TGF beta homologs. We find that while maternal tkv product allows largely normal dorsoventral pattering of the embryo, zygotic tkv activity is indispensable for dorsal closure of the embryo after germ band retraction. Furthermore, tkv activity is crucial for patterning the visceral mesoderm; in the absence of functional tkv gene product, visceral mesoderm parasegment 7 cells fail to express Ultrabithorax, but instead accumulate Antennapedia protein. The tkv receptor is therefore involved in delimiting the expression domains of homeotic genes in the visceral mesoderm. Interestingly, tkv mutants fail to establish a proper tracheal network. Tracheal braches formed by cells migrating in dorsal or ventral directions are absent in tkv mutants. The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily.
This article has been cited by other articles:
|
|
 |
|
  Y. Goltsev, N. Fuse, M. Frasch, R. P. Zinzen, G. Lanzaro, and M. Levine Evolution of the dorsal-ventral patterning network in the mosquito, Anopheles gambiae Development, July 1, 2007; 134(13): 2415 - 2424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Cordero, D. E. Larson, C. R. Craig, R. Hays, and R. Cagan Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina Development, May 15, 2007; 134(10): 1861 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Gibson and N. Perrimon Extrusion and Death of DPP/BMP-Compromised Epithelial Cells in the Developing Drosophila Wing Science, March 18, 2005; 307(5716): 1785 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Morel and A. M. Arias Armadillo/{beta}-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila Development, July 15, 2004; 131(14): 3273 - 3283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Martin and S. M. Parkhurst Parallels between tissue repair and embryo morphogenesis Development, July 1, 2004; 131(13): 3021 - 3034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dorfman, L. Glazer, U. Weihe, M. F. Wernet, and B.-Z. Shilo Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches Development, August 1, 2002; 129(15): 3585 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Glazer and B. Shilo Hedgehog signaling patterns the tracheal branches Development, January 5, 2001; 128(9): 1599 - 1606. [Abstract] [PDF]
|
|
|
|
|
|
J Torres-Vazquez, S Park, R Warrior, and K Arora The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis Development, January 5, 2001; 128(9): 1657 - 1670. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Martin-Blanco, J. C. Pastor-Pareja, and A. Garcia-Bellido From the Cover: JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila PNAS, July 5, 2000; 97(14): 7888 - 7893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-C. Su, C. Maurel-Zaffran, J. E. Treisman, and E. Y. Skolnik The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure, Acting Downstream of Distinct Signals Mol. Cell. Biol., July 1, 2000; 20(13): 4736 - 4744. [Abstract] [Full Text]
|
|
|
|
|
|
K Certel, A Hudson, S. Carroll, and W. Johnson Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor Development, January 7, 2000; 127(14): 3173 - 3183. [Abstract] [PDF]
|
|
|
|
|
|
N Azpiazu and G Morata Function and regulation of homothorax in the wing imaginal disc of Drosophila Development, January 6, 2000; 127(12): 2685 - 2693. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Imam, D. Sutherland, W. Huang, and M. A. Krasnow stumps, a Drosophila Gene Required for Fibroblast Growth Factor (FGF)-directed Migrations of Tracheal and Mesodermal Cells Genetics, May 1, 1999; 152(1): 307 - 318. [Abstract] [Full Text]
|
|
|
|
|
|
J Zeitlinger and D Bohmann Thorax closure in Drosophila: involvement of Fos and the JNK pathway Development, January 9, 1999; 126(17): 3947 - 3956. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Ricos, N Harden, K. Sem, L Lim, and W Chia Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation J. Cell Sci., January 4, 1999; 112(8): 1225 - 1235. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Martín-Blanco, A. Gampel, J. Ring, K. Virdee, N. Kirov, A. M. Tolkovsky, and A. Martinez-Arias puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila Genes & Dev., February 15, 1998; 12(4): 557 - 570. [Abstract] [Full Text]
|
|
|
|
|
|
C. Chen, R. Kuhnlein, K. Eulenberg, S Vincent, M Affolter, and R Schuh The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development Development, January 12, 1998; 125(24): 4959 - 4968. [Abstract] [PDF]
|
|
|
|
|
|
O Khalsa, J. Yoon, S Torres-Schumann, and K. Wharton TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing Development, January 7, 1998; 125(14): 2723 - 2734. [Abstract] [PDF]
|
|
|
|
|
|
Y Chen, M. Riese, M. Killinger, and F. Hoffmann A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A Development, January 5, 1998; 125(9): 1759 - 1768. [Abstract] [PDF]
|
|
|
|
|
|
J. Hudson, S. Podos, K Keith, S. Simpson, and E. Ferguson The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4 Development, January 4, 1998; 125(8): 1407 - 1420. [Abstract] [PDF]
|
|
|
|
|
|
P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling Development, January 4, 1998; 125(8): 1519 - 1528. [Abstract] [PDF]
|
|
|
|
|
|
J R Riesgo-Escovar and E Hafen Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes & Dev., July 1, 1997; 11(13): 1717 - 1727. [Abstract] [PDF]
|
|
|
|
|
|
X S Hou, E S Goldstein, and N Perrimon Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes & Dev., July 1, 1997; 11(13): 1728 - 1737. [Abstract] [PDF]
|
|
|
|
|
|
B Glise and S Noselli Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes & Dev., July 1, 1997; 11(13): 1738 - 1747. [Abstract] [PDF]
|
|
|
|
|
|
P Wappner, L Gabay, and B. Shilo Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes Development, January 11, 1997; 124(22): 4707 - 4716. [Abstract] [PDF]
|
|
|
|
|
|
K Sainio, P Suvanto, J Davies, J Wartiovaara, K Wartiovaara, M Saarma, U Arumae, X Meng, M Lindahl, V Pachnis, et al. Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium Development, January 10, 1997; 124(20): 4077 - 4087. [Abstract] [PDF]
|
|
|
|
|
|
M Llimargas and J Casanova ventral veinless, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila Development, January 9, 1997; 124(17): 3273 - 3281. [Abstract] [PDF]
|
|
|
|
|
|
S Vincent, E Ruberte, N. Grieder, C. Chen, T Haerry, R Schuh, and M Affolter DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo Development, January 7, 1997; 124(14): 2741 - 2750. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing Development, January 3, 1997; 124(5): 1007 - 1018. [Abstract] [PDF]
|
|
|
|
|
|
S Goto and S Hayashi Specification of the embryonic limb primordium by graded activity of Decapentaplegic Development, January 1, 1997; 124(1): 125 - 132. [Abstract] [PDF]
|
|
|
|
|
|
H K Sluss, Z Han, T Barrett, R J Davis, and Y T Ip A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes & Dev., November 1, 1996; 10(21): 2745 - 2758. [Abstract] [PDF]
|
|
|
|
|
|
J R Riesgo-Escovar, M Jenni, A Fritz, and E Hafen The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes & Dev., November 1, 1996; 10(21): 2759 - 2768. [Abstract] [PDF]
|
|
|
|
|
|
R. Kuhnlein and R Schuh Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development Development, July 1, 1996; 122(7): 2215 - 2223. [Abstract] [PDF]
|
|
|
|
|
|
T Uemura, H Oda, R Kraut, S Hayashi, Y Kotaoka, and M Takeichi Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo. Genes & Dev., March 15, 1996; 10(6): 659 - 671. [Abstract] [PDF]
|
|
|
|
|
|
M. Anderson, S. Certel, K Certel, T Lee, D. Montell, and W. Johnson Function of the Drosophila POU domain transcription factor drifter as an upstream regulator of breathless receptor tyrosine kinase expression in developing trachea Development, January 12, 1996; 122(12): 4169 - 4178. [Abstract] [PDF]
|
|
|
|
|
|
C Samakovlis, N Hacohen, G Manning, D. Sutherland, K Guillemin, and M. Krasnow Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events Development, January 5, 1996; 122(5): 1395 - 1407. [Abstract] [PDF]
|
|
|
|
|
|
J D Huang, T Dubnicoff, G J Liaw, Y Bai, S A Valentine, J M Shirokawa, J A Lengyel, and A J Courey Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic. Genes & Dev., December 15, 1995; 9(24): 3177 - 3189. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis, M Llimargas, and J Casanova Ventral veinless, the gene encoding the Cf1a transcription factor, links positional information and cell differentiation during embryonic and imaginal development in Drosophila melanogaster Development, January 10, 1995; 121(10): 3405 - 3416. [Abstract] [PDF]
|
|
|
|
|
|
M. Pankratz and M Hoch Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut Development, January 6, 1995; 121(6): 1885 - 1898. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Raymond, E. Bergeret, M.-C. Dagher, R. Breton, R. Griffin-Shea, and M.-O. Fauvarque The Rac GTPase-activating Protein RotundRacGAP Interferes with Drac1 and Dcdc42 Signalling in Drosophila melanogaster J. Biol. Chem., September 14, 2001; 276(38): 35909 - 35916. [Abstract] [Full Text] [PDF]
|
|
