|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 12 3439-3450, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
M Hoch, K Broadie, H Jackle and H Skaer
Max-Planck-Institut fur Biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, FRG.
In each Malpighian tubule of Drosophila, one cell is singled out, the tip cell, whose function during embryogenesis is to promote cell division in its neighbours. We follow the segregation of this cell, explore the genetic interactions that underlie its specification and demonstrate that tip cell allocation closely resembles neurogenesis. The tip cell arises by division of a tip mother cell, which is selected from a cluster of equivalent cells in each tubule primordium. Each cluster is marked out by the expression of proneural genes and the selection of a single cell from each group involves lateral inhibition, mediated by the neurogenic genes. We confirm the mitogenic role of the tip cell during embryogenesis by mutational analysis and show that it subsequently adopts a second fate, differentiating neural characteristics. We demonstrate that both stages in the differentiation of this cell are established by the same sequence of genetic interactions, which have not previously been shown to occur outside the neurogenic ectoderm.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Roca and R. H. Adams Regulation of vascular morphogenesis by Notch signaling Genes & Dev., October 15, 2007; 21(20): 2511 - 2524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Harris and S. K. Beckendorf Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration Development, June 1, 2007; 134(11): 2017 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Keller Mechanisms of elongation in embryogenesis Development, June 15, 2006; 133(12): 2291 - 2302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Jung, B. Denholm, H. Skaer, and M. Affolter Renal Tubule Development in Drosophila: A Closer Look at the Cellular Level J. Am. Soc. Nephrol., February 1, 2005; 16(2): 322 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. T. DOW and S. A. DAVIES Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism Physiol Rev, July 1, 2003; 83(3): 687 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sudarsan, S. Pasalodos-Sanchez, S. Wan, A. Gampel, and H. Skaer A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila Development, March 4, 2003; 129(4): 935 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rusten, R Cantera, J Urban, G Technau, F. Kafatos, and R Barrio Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes Development, January 3, 2001; 128(5): 711 - 722. [Abstract] [PDF]
|
|
|
|
|
|
B San Martin and M Bate Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila Development, January 1, 2001; 128(2): 233 - 242. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Liu, I. Kiss, and J. A. Lengyel Identification of Genes Controlling Malpighian Tubule and Other Epithelial Morphogenesis in Drosophila melanogaster Genetics, February 1, 1999; 151(2): 685 - 695. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Carrera, S. Abrell, B. Kerber, U. Walldorf, A. Preiss, M. Hoch, and H. Jackle A modifier screen in the eye reveals control genes for Kruppel activity in the Drosophila embryo PNAS, September 1, 1998; 95(18): 10779 - 10784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kerber, S. Fellert, and M. Hoch Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney Genes & Dev., June 15, 1998; 12(12): 1781 - 1786. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Sozen, J. D. Armstrong, M. Yang, K. Kaiser, and J. A. T. Dow Functional domains are specified to single-cell resolution in a Drosophila epithelium PNAS, May 13, 1997; 94(10): 5207 - 5212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Ruiz Gomez and M Bate Segregation of myogenic lineages in Drosophila requires numb Development, January 12, 1997; 124(23): 4857 - 4866. [Abstract] [PDF]
|
|
|
|
 |
|
 P Rosay, S. Davies, Y Yu, A Sozen, K Kaiser, and J. Dow Cell-type specific calcium signalling in a Drosophila epithelium J. Cell Sci., January 8, 1997; 110(15): 1683 - 1692. [Abstract] [PDF]
|
|
|
|
|
|
D Schmucker, H Jackle, and U Gaul Genetic analysis of the larval optic nerve projection in Drosophila Development, January 3, 1997; 124(5): 937 - 948. [Abstract] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
