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Development, Vol 120, Issue 12 3537-3548, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
B Jennings, A Preiss, C Delidakis and S Bray
Department of Anatomy, University of Cambridge, UK.
The Enhancer of split locus is required during many cell-fate decisions in Drosophila, including the segregation of neural precursors in the embryo. We have generated monoclonal antibodies that recognise some of the basic helix-loop-helix proteins encoded by the Enhancer of split locus and have used them to examine expression of Enhancer of split proteins during neurogenesis. The proteins are expressed in a dynamic pattern in the ventral neurogenic region and are confined to those ectodermal cells that surround a neuroblast in the process of delaminating. There is no staining in the neuroblasts themselves. We have also examined the relationship between Enhancer of split protein accumulation and the Notch signalling pathway. Protein expression is abolished in a number of neurogenic mutant backgrounds, including Notch, but is increased as a result of expressing a constitutively active Notch product. We conclude that Notch signalling activity is directly responsible for the accumulation of basic helix-loop-helix proteins encoded by the Enhancer of split locus.
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K Matsuno, M. Go, X Sun, D. Eastman, and S Artavanis-Tsakonas Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements Development, January 11, 1997; 124(21): 4265 - 4273. [Abstract] [PDF]
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J. de Celis and S Bray Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing Development, January 9, 1997; 124(17): 3241 - 3251. [Abstract] [PDF]
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X Sun and S Artavanis-Tsakonas Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Development, January 9, 1997; 124(17): 3439 - 3448. [Abstract] [PDF]
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J. de Celis, S Bray, and A Garcia-Bellido Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing Development, January 5, 1997; 124(10): 1919 - 1928. [Abstract] [PDF]
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D. Wettstein, D. Turner, and C Kintner The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis Development, January 2, 1997; 124(3): 693 - 702. [Abstract] [PDF]
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C Shawber, D Nofziger, J. Hsieh, C Lindsell, O Bogler, D Hayward, and G Weinmaster Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway Development, January 12, 1996; 122(12): 3765 - 3773. [Abstract] [PDF]
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J. de Celis, J de Celis, P Ligoxygakis, A Preiss, C Delidakis, and S Bray Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development Development, January 9, 1996; 122(9): 2719 - 2728. [Abstract] [PDF]
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X Sun and S Artavanis-Tsakonas The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands Development, January 8, 1996; 122(8): 2465 - 2474. [Abstract] [PDF]
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R Baker and G Schubiger Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila Development, January 2, 1996; 122(2): 617 - 626. [Abstract] [PDF]
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P Heitzler, M Bourouis, L Ruel, C Carteret, and P Simpson Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila Development, January 1, 1996; 122(1): 161 - 171. [Abstract] [PDF]
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J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]
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M Lecourtois and F Schweisguth The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes & Dev., November 1, 1995; 9(21): 2598 - 2608. [Abstract] [PDF]
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A M Bailey and J W Posakony Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes & Dev., November 1, 1995; 9(21): 2609 - 2622. [Abstract] [PDF]
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 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
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J. de Celis and M Ruiz-Gomez groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing Development, January 10, 1995; 121(10): 3467 - 3476. [Abstract] [PDF]
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R. L. Trott, M. Kalive, Z. Paroush, and A. P. Bidwai Drosophila melanogaster Casein Kinase II Interacts with and Phosphorylates the Basic Helix-Loop-Heli |
