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Development, Vol 120, Issue 12 3581-3593, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells

C Chiang, NH Patel, KE Young and PA Beachy
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

We have identified a novel homeodomain gene, buttonless (btn), that is specifically expressed in 20 cells of a single type during Drosophila embryonic development. These cells, the dorsal median (DM) cells, are arranged as a single pair within each segment along the dorsal midline of the CNS. Distinctive features of the DM cells include a large cell body and a long thick process extending laterally to the muscle attachment site. In the absence of btn gene function the initial commitment to the DM cell fate is made but differentiation fails to occur and the DM cells are lost. The btn mutation thus specifically eliminates the DM cells, and this genetic ablation in turn reveals a requirement for DM cells as cellular cues for axonal guidance during transverse nerve outgrowth and bifurcation of the median nerve.


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© The Company of Biologists Ltd 1994