|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 3 515-522, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
SC Lin, S Li, DW Drolet and MG Rosenfeld
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648.
The anterior pituitary provides a model to study the molecular mechanisms responsible for emergence of distinct cell types within an organ. Dwarf mice (Snell) that express a mutant form of the tissue-specific POU-domain transcription factor Pit-1 fail to generate three cell types, including the thyrotrope (S. Li, E. B. Crenshaw, E. J. Rawson, D. S. Simmons, L. Swanson and M. G. Rosenfeld (1990), Nature 347, 528-533). Analyses of wild-type and Pit-1-defective mice, presented here, have revealed that thyrotropes unexpectedly arise from two independent cell populations. The first population is Pit-1-independent and appears on e12 in the rostral tip of the developing gland, but phenotypically disappears by the day of birth. The second is Pit-1-dependent and arises subsequently in the caudomedial portion of the developing gland (e15.5), following the initial expression of Pit-1 in this region. The failure of caudomedial thyrotrope cells to appear in the Snell dwarf, and the observation that Pit-1 can bind to and transactivate the TSH beta promoter, apparently enhanced by its phosphorylation, suggests that Pit-1 is directly required for the appearance of this distinct population that serves as the precursors of the mature thyrotrope cell type. These data suggest that different molecular mechanisms, based on the actions of distinct transcription factors, can serve to independently generate a specific cell phenotype during mammalian organogenesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. T. McElvaine, A. I. Korytko, S. M. Kilen, L. Cuttler, and K. E. Mayo Pituitary-Specific Expression and Pit-1 Regulation of the Rat Growth Hormone-Releasing Hormone Receptor Gene Mol. Endocrinol., August 1, 2007; 21(8): 1969 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wells Redefining Ancestral Relationships in Pituitary Cell Genealogy Endocrinology, May 1, 2007; 148(5): 1943 - 1945. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Milenkovic, X. De Deken, L. Jin, M. De Felice, R. Di Lauro, J. E Dumont, B. Corvilain, and F. Miot Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult J. Endocrinol., March 1, 2007; 192(3): 615 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sato, K. Kitahara, T. Susa, T. Kato, and Y. Kato Pituitary transcription factor Prop-1 stimulates porcine pituitary glycoprotein hormone {alpha} subunit gene expression. J. Mol. Endocrinol., October 1, 2006; 37(2): 341 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nagasaki, Z. Wang, V. R Jackson, S. Lin, H.-P. Nothacker, and O. Civelli Differential expression of the thyrostimulin subunits, glycoprotein {alpha}2 and {beta}5 in the rat pituitary. J. Mol. Endocrinol., August 1, 2006; 37(1): 39 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sun, F. Zhang, J. Gao, X. Gao, T. Guo, K. Zhang, Y. Shi, Z. Zheng, W. Tang, Y. Zheng, et al. Positive association between POU1F1 and mental retardation in young females in the Chinese Han population Hum. Mol. Genet., April 1, 2006; 15(7): 1237 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Cohen, T. Brue, K. Naik, C. A. Houlihan, F. E. Wondisford, and S. Radovick The Role of CBP/p300 Interactions and Pit-1 Dimerization in the Pathophysiological Mechanism of Combined Pituitary Hormone Deficiency J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 239 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Hu, F. Li, H.-M. Yu, R.-Y. Li, Q.-Y. Ma, T.-J. Ye, Z.-Y. Lu, J.-L. Chen, and H.-D. Song The Mimecan Gene Expressed in Human Pituitary and Regulated by Pituitary Transcription Factor-1 as a Marker for Diagnosing Pituitary Tumors J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6657 - 6664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Huerta-Ocampo, H. C. Christian, N. M. Thompson, M. M. El-Kasti, and T. Wells The Intermediate Lactotroph: A Morphologically Distinct, Ghrelin-Responsive Pituitary Cell in the Dwarf (dw/dw) Rat Endocrinology, November 1, 2005; 146(11): 5012 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Gil-Puig, S Seoane, M Blanco, M Macia, T Garcia-Caballero, C Segura, and R Perez-Fernandez Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation Eur. J. Endocrinol., August 1, 2005; 153(2): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muchow, I. Bossis, and T. E Porter Ontogeny of pituitary thyrotrophs and regulation by endogenous thyroid hormone feedback in the chick embryo J. Endocrinol., February 1, 2005; 184(2): 407 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. De Felice, M. P. Postiglione, and R. Di Lauro Minireview: Thyrotropin Receptor Signaling in Development and Differentiation of the Thyroid Gland: Insights from Mouse Models and Human Diseases Endocrinology, September 1, 2004; 145(9): 4062 - 4067. [Full Text] [PDF]
|
|
|
|
|
|
W. Herzog, C. Sonntag, B. Walderich, J. Odenthal, H.-M. Maischein, and M. Hammerschmidt Genetic Analysis of Adenohypophysis Formation in Zebrafish Mol. Endocrinol., May 1, 2004; 18(5): 1185 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nica, W. Herzog, C. Sonntag, and M. Hammerschmidt Zebrafish pit1 Mutants Lack Three Pituitary Cell Types and Develop Severe Dwarfism Mol. Endocrinol., May 1, 2004; 18(5): 1196 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Pulichino, S. Vallette-Kasic, J. P.-Y. Tsai, C. Couture, Y. Gauthier, and J. Drouin Tpit determines alternate fates during pituitary cell differentiation Genes & Dev., March 15, 2003; 17(6): 738 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hashimoto, M. Cisternino, and L. E. Cohen A Novel Nonsense Mutation in the Pit-1 Gene: Evidence for a Gene Dosage Effect J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1241 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Klosen, C. Bienvenu, O. Demarteau, H. Dardente, H. Guerrero, P. Pevet, and M. Masson-Pevet The mt1 Melatonin Receptor and ROR{beta} Receptor Are Co-localized in Specific TSH-immunoreactive Cells in the Pars Tuberalis of the Rat Pituitary J. Histochem. Cytochem., December 1, 2002; 50(12): 1647 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Marians, L. Ng, H. C. Blair, P. Unger, P. N. Graves, and T. F. Davies Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice PNAS, November 26, 2002; 99(24): 15776 - 15781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Cohen and S. Radovick Molecular Basis of Combined Pituitary Hormone Deficiencies Endocr. Rev., August 1, 2002; 23(4): 431 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Andersen and M. G. Rosenfeld POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease Endocr. Rev., February 1, 2001; 22(1): 2 - 35. [Abstract] [Full Text]
|
|
|
|
|
|
J. Iqbal, S. Pompolo, R. V. Considine, and I. J. Clarke Localization of Leptin Receptor-Like Immunoreactivity in the Corticotropes, Somatotropes, and Gonadotropes in the Ovine Anterior Pituitary Endocrinology, April 1, 2000; 141(4): 1515 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Baumeister, M. Wegner, D. Richter, and W. Meyerhof Dual Regulation Of Somatostatin Receptor Subtype 1 Gene Expression By Pit-1 In Anterior Pituitary GH3 Cells Mol. Endocrinol., February 1, 2000; 14(2): 255 - 271. [Abstract] [Full Text]
|
|
|
|
 |
|
 M Sander, L Sussel, J Conners, D Scheel, J Kalamaras, F Dela Cruz, V Schwitzgebel, A Hayes-Jordan, and M German Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas Development, January 12, 2000; 127(24): 5533 - 5540. [Abstract] [PDF]
|
|
|
|
|
|
C. Lanctôt, Y. Gauthier, and J. Drouin Pituitary Homeobox 1 (Ptx1) Is Differentially Expressed during Pituitary Development Endocrinology, March 1, 1999; 140(3): 1416 - 1422. [Abstract] [Full Text]
|
|
|
|
|
|
D. P. Szeto, C. Rodriguez-Esteban, A. K. Ryan, S. M. O'Connell, F. Liu, C. Kioussi, A. S. Gleiberman, J. C. Izpisúa-Belmonte, and M. G. Rosenfeld Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development Genes & Dev., February 15, 1999; 13(4): 484 - 494. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Asa and S. Ezzat The Cytogenesis and Pathogenesis of Pituitary Adenomas Endocr. Rev., December 1, 1998; 19(6): 798 - 827. [Abstract] [Full Text]
|
|
|
|
|
|
H. Yano, C. Readhead, M. Nakashima, S.-G. Ren, and S. Melmed Pituitary-Directed Leukemia Inhibitory Factor Transgene Causes Cushing's Syndrome: Neuro-Immune-Endocrine Modulation of Pituitary Development Mol. Endocrinol., November 1, 1998; 12(11): 1708 - 1720. [Abstract] [Full Text]
|
|
|
|
|
|
B. Yusta, E. T. Alarid, D. F. Gordon, E. C. Ridgway, and P. L. Mellon The Thyrotropin {beta}-Subunit Gene Is Repressed by Thyroid Hormone in a Novel Thyrotrope Cell Line, Mouse T{alpha}T1 Cells Endocrinology, November 1, 1998; 139(11): 4476 - 4482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Flück, J. Deladoey, K. Rutishauser, A. Eblé, U. Marti, W. Wu, and P. E. Mullis Phenotypic Variability in Familial Combined Pituitary Hormone Deficiency Caused by a PROP1 Gene Mutation Resulting in the Substitution of Arg->Cys at Codon 120 (R120C) J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3727 - 3734. [Abstract] [Full Text]
|
|
|
|
|
|
J Ericson, S Norlin, T. Jessell, and T Edlund Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary Development, January 3, 1998; 125(6): 1005 - 1015. [Abstract] [PDF]
|
|
|
|
 |
|
 D. F. Gordon, S. R. Lewis, B. R. Haugen, R. A. James, M. T. McDermott, W. M. Wood, and E. C. Ridgway Pit-1 and GATA-2 Interact and Functionally Cooperate to Activate the Thyrotropin beta -Subunit Promoter J. Biol. Chem., September 26, 1997; 272(39): 24339 - 24347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bockmann, T. M. Bockers, C. Winter, W. Wittkowski, H. Winterhoff, Th. Deufel, and M. R. Kreutz Thyrotropin Expression in Hypophyseal Pars Tuberalis-Specific Cells is 3,5,3'-Triiodothyronine, Thyrotropin-Releasing Hormone, and Pit-1 Independent Endocrinology, March 1, 1997; 138(3): 1019 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delhase, J.-L. Castrillo, M. de la Hoya, F. Rajas, and E. L. Hooghe-Peters AP-1 and Oct-1 Transcription Factors Down-regulate the Expression of the Human PIT1/GHF1 Gene J. Biol. Chem., December 13, 1996; 271(50): 32349 - 32358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Wood, J. M. Dowding, T. M. Bright, M. T. McDermott, B. R. Haugen, D. F. Gordon, and E. C. Ridgway Thyroid Hormone Receptor beta 2 Promoter Activity in Pituitary Cells Is Regulated by Pit-1 J. Biol. Chem., September 27, 1996; 271(39): 24213 - 24220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Alarid, J. Windle, D. Whyte, and P. Mellon Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice Development, January 10, 1996; 122(10): 3319 - 3329. [Abstract] [PDF]
|
|
|
|
|
|
E Hermesz, S Mackem, and K. Mahon Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo Development, January 1, 1996; 122(1): 41 - 52. [Abstract] [PDF]
|
|
|
|
|
|
P. Gage, M. Roller, T. Saunders, L. Scarlett, and S. Camper Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion Development, January 1, 1996; 122(1): 151 - 160. [Abstract] [PDF]
|
|
|
|
|
|
J M Holloway, D P Szeto, K M Scully, C K Glass, and M G Rosenfeld Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain. Genes & Dev., August 15, 1995; 9(16): 1992 - 2006. [Abstract] [PDF]
|
|
|
|
|
|
K. P. Smith, B. Liu, C. Scott, and Z. D. Sharp Pit-1 Exhibits a Unique Promoter Spacing Requirement for Activation and Synergism J. Biol. Chem., March 3, 1995; 270(9): 4484 - 4491. [Abstract] [Full Text] [PDF]
|
|
