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Development, Vol 120, Issue 3 535-544, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
SA Speicher, U Thomas, U Hinz and E Knust
Institut fur Entwicklungsbiologie, Universitat zu Koln, FRG.
The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality. Homozygous mutant larvae fail to differentiate the anterior spiracles, exhibit poorly developed mouth-hooks and show a severe reduction in the size of the wing and haltere primordia, which is not due to cell death. The few homozygous mutant escapers that pupariate develop into pharate adults that almost completely lack wings and halteres. Clonal analysis in the adult epidermis demonstrates a requirement for Serrate during wing and haltere development. Targeted ectopic expression of Serrate in the imaginal discs using the yeast transcriptional activator Gal4 results in regionally restricted induction of cell proliferation, e.g. the ventral tissues in the case of the wings and halteres. The results suggest that the wild-type function of Serrate is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis.
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J. de Celis, J de Celis, P Ligoxygakis, A Preiss, C Delidakis, and S Bray Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development Development, January 9, 1996; 122(9): 2719 - 2728. [Abstract] [PDF]
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J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]
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M Lecourtois and F Schweisguth The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes & Dev., November 1, 1995; 9(21): 2598 - 2608. [Abstract] [PDF]
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S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
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R. Johnson, J. Grenier, and M. Scott patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets Development, January 12, 1995; 121(12): 4161 - 4170. [Abstract] [PDF]
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F. Diaz-Benjumea and S. Cohen Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing Development, January 12, 1995; 121(12): 4215 - 4225. [Abstract] [PDF]
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M. Sturtevant and E Bier Analysis of the genetic hierarchy guiding wing vein development in Drosophila Development, January 3, 1995; 121(3): 785 - 801. [Abstract] [PDF]
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Y Gu, N. Hukriede, and R. Fleming Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo Development, January 3, 1995; 121(3): 855 - 865. [Abstract] [PDF]
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E. Wilder and N Perrimon Dual functions of wingless in the Drosophila leg imaginal disc Development, January 2, 1995; 121(2): 477 - 488. [Abstract] [PDF]
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