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Development, Vol 120, Issue 3 569-578, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
FJ Diaz-Benjumea and E Hafen
Zoologisches Institut, Universitat Zurich, Switzerland.
In Drosophila, Drk, an SH2 adaptor protein, Sos, a putative activator of Ras1, Ras1, raf and rolled/MAP kinase have been shown to be required for signalling from the sevenless and the torso receptor tyrosine kinase. From these studies, it was unclear whether these components act in a single linear pathway as suggested by the genetic analysis or whether different components serve to integrate different signals. We have analyzed the effects of removing each of these components during the development of the adult epidermal structures by generating clones of homozygous mutant cells in a heterozygous background. Mutations in each of these signalling components produce a very similar set of phenotypes. These phenotypes resemble those caused by loss-of-function mutations in the Drosophila EGF receptor homolog (DER). It appears that these components form a signalling cassette, which mediates all aspects of DER signalling but that is not required for other signalling processes during epidermal development.
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M Golembo, E Raz, and B. Shilo The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm Development, January 11, 1996; 122(11): 3363 - 3370. [Abstract] [PDF]
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J Montagne, J Groppe, K Guillemin, M. Krasnow, W. Gehring, and M Affolter The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered Development, January 9, 1996; 122(9): 2589 - 2597. [Abstract] [PDF]
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K. Cadigan and R Nusse wingless signaling in the Drosophila eye and embryonic epidermis Development, January 9, 1996; 122(9): 2801 - 2812. [Abstract] [PDF]
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M Golembo, R Schweitzer, M Freeman, and B. Shilo Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop Development, January 1, 1996; 122(1): 223 - 230. [Abstract] [PDF]
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S Kramer, S. West, and Y Hiromi Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway Development, January 5, 1995; 121(5): 1361 - 1372. [Abstract] [PDF]
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M Ng, F. Diaz-Benjumea, and S. Cohen Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing Development, January 2, 1995; 121(2): 589 - 599. [Abstract] [PDF]
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D. Fristrom, P. Gotwals, S. Eaton, T. B. Kornberg, M. Sturtevant, E. Bier, and J. W. Fristrom Blistered: a gene required for vein/intervein formation in wings of Drosophila Development, September 1, 1994; 120(9): 2661 - 2671. [Abstract] [PDF]
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