|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 3 621-636, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
JP Couso, SA Bishop and A Martinez Arias
Department of Zoology, University of Cambridge, UK.
The margin of the wing of Drosophila is defined and patterned from a stripe of cells expressing the wingless (wg) gene that is established during the third larval instar in the developing wing blade. The expression of the genes cut and achaete in a small domain in the prospective wing margin region reflects the activity of wg and probably mediate its function. Our results indicate that, in the wing margin, the wingless signal requires the activity of at least three genes: armadillo (arm), dishevelled (dsh) and shaggy (sgg) and that the functional relationship between these genes and wg is the same as that which exist during the patterning of the larval epidermis. These observations indicate that arm, dsh and sgg encode elements of a unique 'wingless signalling pathway' that is used several times throughout development.
This article has been cited by other articles:
|
|
 |
|
  K. Sato, T. M. Matsunaga, R. Futahashi, T. Kojima, K. Mita, Y. Banno, and H. Fujiwara Positional Cloning of a Bombyx Wingless Locus flugellos (fl) Reveals a Crucial Role for fringe That Is Specific for Wing Morphogenesis Genetics, June 1, 2008; 179(2): 875 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Prince, T. Katsuyama, Y. Oshima, S. Plaza, D. Resendez-Perez, M. Berry, S. Kurata, and W. J. Gehring The YPWM motif links Antennapedia to the basal transcriptional machinery Development, May 1, 2008; 135(9): 1669 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hayward, T. Kalmar, and A. Martinez Arias Wnt/Notch signalling and information processing during development Development, February 1, 2008; 135(3): 411 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chung, S. Kim, J. Yoon, P. N. Adler, and J. Yim The Balance Between the Novel Protein Target of Wingless and the Drosophila Rho-Associated Kinase Pathway Regulates Planar Cell Polarity in the Drosophila Wing Genetics, June 1, 2007; 176(2): 891 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Felix, M. Magarinos, and F. J. Diaz-Benjumea Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development Development, May 15, 2007; 134(10): 1845 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Goodman, S. Thombre, Z. Firtina, D. Gray, D. Betts, J. Roebuck, E. P. Spana, and E. M. Selva Sprinter: a novel transmembrane protein required for Wg secretion and signaling Development, December 15, 2006; 133(24): 4901 - 4911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez, C. Chaouiya, and D. Thieffry Dynamical Analysis of the Regulatory Network Defining the Dorsal-Ventral Boundary of the Drosophila Wing Imaginal Disc Genetics, November 1, 2006; 174(3): 1625 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Waldrop, C.-C. Chan, T. Cagatay, S. Zhang, R. Rousset, J. Mack, W. Zeng, M. Fish, M. Zhang, M. Amanai, et al. An Unconventional Nuclear Localization Motif Is Crucial for Function of the Drosophila Wnt/Wingless Antagonist Naked Cuticle Genetics, September 1, 2006; 174(1): 331 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jafar-Nejad, A.-C. Tien, M. Acar, and H. J. Bellen Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin Development, May 1, 2006; 133(9): 1683 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Seto and H. J. Bellen Internalization is required for proper Wingless signaling in Drosophila melanogaster. J. Cell Biol., April 10, 2006; 173(1): 95 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaiswal, N. Agrawal, and P. Sinha Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila Development, March 1, 2006; 133(5): 925 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Hanson, A. C. Kelley, and M. Bienz Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development Development, November 1, 2005; 132(21): 4777 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Takaesu, E. Herbig, D. Zhitomersky, M. B. O'Connor, and S. J. Newfeld DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila Development, November 1, 2005; 132(21): 4883 - 4894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Wallingford and R. Habas The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity Development, October 15, 2005; 132(20): 4421 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Franch-Marro, O. Marchand, E. Piddini, S. Ricardo, C. Alexandre, and J.-P. Vincent Glypicans shunt the Wingless signal between local signalling and further transport Development, February 15, 2005; 132(4): 659 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amoyel, Y.-C. Cheng, Y.-J. Jiang, and D. G. Wilkinson Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain Development, February 15, 2005; 132(4): 775 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho and K. D. Irvine Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling Development, September 15, 2004; 131(18): 4489 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. A. Zeng and E. M. Verheyen Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development Development, June 15, 2004; 131(12): 2911 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Bornemann, J. E. Duncan, W. Staatz, S. Selleck, and R. Warrior Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways Development, May 1, 2004; 131(9): 1927 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Giraldez and S. M. Cohen Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development Development, December 29, 2003; 130(26): 6533 - 6543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schweizer, D. Nellen, and K. Basler Requirement for Pangolin/dTCF in Drosophila Wingless signaling PNAS, May 13, 2003; 100(10): 5846 - 5851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster Development, March 14, 2003; 129(24): 5553 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Cadigan, A. D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development, March 9, 2003; 129(14): 3393 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsuno, M. Ito, K. Hori, F. Miyashita, S. Suzuki, N. Kishi, S. Artavanis-Tsakonas, and H. Okano Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling Development, March 4, 2003; 129(4): 1049 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. d. A. Rodriguez, J. Terriente, M. I. Galindo, J. P. Couso, and F. J. Diaz-Benjumea Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge Development, September 1, 2002; 129(17): 3995 - 4004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Y. Belenkaya, C. Han, H. J. Standley, X. Lin, D. W. Houston, J. Heasman, and X. Lin pygopus encodes a nuclear protein essential for Wingless/Wnt signaling Development, September 1, 2002; 129(17): 4089 - 4101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gerlitz and K. Basler Wingful, an extracellular feedback inhibitor of Wingless Genes & Dev., May 1, 2002; 16(9): 1055 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, J. Shin, H.-C. Park, S.-Y. Yeo, S.-K. Hong, S. Han, M. Rhee, C.-H. Kim, A. B. Chitnis, and T.-L. Huh Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish Development, January 10, 2002; 129(19): 4443 - 4455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ahmed, A. Nouri, and E. Wieschaus Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development Development, January 4, 2002; 129(7): 1751 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Baeg, X Lin, N Khare, S Baumgartner, and N Perrimon Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless Development, January 1, 2001; 128(1): 87 - 94. [Abstract] [PDF]
|
|
|
|
|
|
R. Nolo, L. A. Abbott, and H. J. Bellen Drosophila Lyra Mutations Are Gain-of-Function Mutations of senseless Genetics, January 1, 2001; 157(1): 307 - 315. [Abstract] [Full Text]
|
|
|
|
|
|
T Chihara and S Hayashi Control of tracheal tubulogenesis by Wingless signaling Development, January 10, 2000; 127(20): 4433 - 4442. [Abstract] [PDF]
|
|
|
|
|
|
S. Day and P. Lawrence Measuring dimensions: the regulation of size and shape Development, January 7, 2000; 127(14): 2977 - 2987. [Abstract] [PDF]
|
|
|
|
|
|
F Casares and R. Mann A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila Development, January 4, 2000; 127(7): 1499 - 1508. [Abstract] [PDF]
|
|
|
|
|
|
S. Greaves, B. Sanson, P. White, and J.-P. Vincent A Screen for Identifying Genes Interacting With Armadillo, the Drosophila Homolog of {beta}-Catenin Genetics, December 1, 1999; 153(4): 1753 - 1766. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Kiger , Jr., J. L. Eklund, S. H. Younger, and C. J. O'Kane Transgenic Inhibitors Identify Two Roles for Protein Kinase A in Drosophila Development Genetics, May 1, 1999; 152(1): 281 - 290. [Abstract] [Full Text]
|
|
|
|
|
|
A Sato, T Kojima, K Ui-Tei, Y Miyata, and K Saigo Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants Development, January 10, 1999; 126(20): 4421 - 4430. [Abstract] [PDF]
|
|
|
|
|
|
K Willert, C. Logan, A Arora, M Fish, and R Nusse A Drosophila Axin homolog, Daxin, inhibits Wnt signaling Development, January 9, 1999; 126(18): 4165 - 4173. [Abstract] [PDF]
|
|
|
|
|
|
P Bhanot, M Fish, J. Jemison, R Nusse, J Nathans, and K. Cadigan Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development Development, January 9, 1999; 126(18): 4175 - 4186. [Abstract] [PDF]
|
|
|
|
|
|
M. Garcia-Garcia, P Ramain, P Simpson, and J Modolell Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila Development, January 8, 1999; 126(16): 3523 - 3532. [Abstract] [PDF]
|
|
|
|
|
|
G Morata and E Sanchez-Herrero Patterning mechanisms in the body trunk and the appendages of Drosophila Development, January 7, 1999; 126(13): 2823 - 2828. [Abstract] [PDF]
|
|
|
|
|
|
S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
R. Widelitz, T. Jiang, C. Chen, N. Stott, and C. Chuong Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model Development, January 6, 1999; 126(12): 2577 - 2587. [Abstract] [PDF]
|
|
|
|
|
|
P Ligoxygakis, S. Bray, Y Apidianakis, and C Delidakis Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila Development, January 5, 1999; 126(10): 2205 - 2214. [Abstract] [PDF]
|
|
|
|
|
|
T Klein and A. Arias The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila Development, January 2, 1999; 126(5): 913 - 925. [Abstract] [PDF]
|
|
|
|
|
|
R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial Development, January 2, 1999; 126(5): 975 - 985. [Abstract] [PDF]
|
|
|
|
|
|
M. Milán, F. J. Diaz-Benjumea, and S. M. Cohen Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function Genes & Dev., September 15, 1998; 12(18): 2912 - 2920. [Abstract] [Full Text]
|
|
|
|
|
|
S. D. Weatherbee, G. Halder, J. Kim, A. Hudson, and S. Carroll Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere Genes & Dev., May 15, 1998; 12(10): 1474 - 1482. [Abstract] [Full Text]
|
|
|
|
|
|
P. White, H. Aberle, and J.-P. Vincent Signaling and Adhesion Activities of Mammalian beta -Catenin and Plakoglobin in Drosophila J. Cell Biol., January 12, 1998; 140(1): 183 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Campbell and A Tomlinson The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila Development, January 11, 1998; 125(22): 4483 - 4493. [Abstract] [PDF]
|
|
|
|
|
|
J Zhang and R. Carthew Interactions between Wingless and DFz2 during Drosophila wing development Development, January 8, 1998; 125(16): 3075 - 3085. [Abstract] [PDF]
|
|
|
|
|
|
K. M. Cadigan and R. Nusse Wnt signaling: a common theme in animal development Genes & Dev., December 15, 1997; 11(24): 3286 - 3305. [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Yanagawa, J.-S. Lee, T. Haruna, H. Oda, T. Uemura, M. Takeichi, and A. Ishimoto Accumulation of Armadillo Induced by Wingless, Dishevelled, and Dominant-negative Zeste-white 3 Leads to Elevated DE-cadherin in Drosophila Clone 8 Wing Disc Cells J. Biol. Chem., October 3, 1997; 272(40): 25243 - 25251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins Genes & Dev., August 1, 1997; 11(15): 1949 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Majumdar, R Nagaraj, and U Banerjee strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes & Dev., May 15, 1997; 11(10): 1341 - 1353. [Abstract] [PDF]
|
|
|
|
|
|
S. Jackson, H Nakato, M Sugiura, A Jannuzi, R Oakes, V Kaluza, C Golden, and S. Selleck dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp Development, January 10, 1997; 124(20): 4113 - 4120. [Abstract] [PDF]
|
|
|
|
|
|
U Hacker, X Lin, and N Perrimon The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis Development, January 9, 1997; 124(18): 3565 - 3573. [Abstract] [PDF]
|
|
|
|
|
|
M Duman-Scheel, X Li, I Orlov, M Noll, and N. Patel Genetic separation of the neural and cuticular patterning functions of gooseberry Development, January 8, 1997; 124(15): 2855 - 2865. [Abstract] [PDF]
|
|
|
|
|
|
T. Haerry, T. Heslip, J. Marsh, and M. O'Connor Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila Development, January 8, 1997; 124(16): 3055 - 3064. [Abstract] [PDF]
|
|
|
|
|
|
R. Binari, B. Staveley, W. Johnson, R Godavarti, R Sasisekharan, and A. Manoukian Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling Development, January 7, 1997; 124(13): 2623 - 2632. [Abstract] [PDF]
|
|
|
|
|
|
C. Micchelli, E. Rulifson, and S. Blair The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate Development, January 4, 1997; 124(8): 1485 - 1495. [Abstract] [PDF]
|
|
|
|
|
|
C. Neumann and S. Cohen Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing Development, January 2, 1997; 124(4): 871 - 880. [Abstract] [PDF]
|
|
|
|
|
|
T Kadowaki, E Wilder, J Klingensmith, K Zachary, and N Perrimon The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes & Dev., December 15, 1996; 10(24): 3116 - 3128. [Abstract] [PDF]
|
|
|
|
|
|
J L Gomez-Skarmeta and J Modolell araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes & Dev., November 15, 1996; 10(22): 2935 - 2945. [Abstract] [PDF]
|
|
