|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 4 717-728, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
EM Verheyen and L Cooley
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
The chickadee gene of Drosophila encodes profilin, a small actin binding protein. We present the first analysis of the effects of profilin deletion in a multicellular organism. Genomic deletions of the chickadee locus result in a late embryonic lethal phenotype indicating that profilin is essential in flies. In addition, viable alleles of chickadee with defects in oogenesis, spermatogenesis and bristle formation provide insight into profilin function in a variety of cell types. Defects in oogenesis include the previously described failure to assemble nurse cell actin filament bundles in addition to abnormal regulation of mitosis, binucleate cells and stalled cell migration. Malformed bristles are a result of aberrant actin assembly. Monoclonal antibodies against Drosophila profilin were generated to study profilin's cellular and subcellular localization.
This article has been cited by other articles:
|
|
 |
|
  T. Noguchi, M. Lenartowska, A. D. Rogat, D. J. Frank, and K. G. Miller Proper Cellular Reorganization during Drosophila Spermatid Individualization Depends on Actin Structures Composed of Two Domains, Bundles and Meshwork, That Are Differentially Regulated and Have Different Functions Mol. Biol. Cell, June 1, 2008; 19(6): 2363 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ren, J. Charlton, and P. N. Adler The flare Gene, Which Encodes the AIP1 Protein of Drosophila, Functions to Regulate F-Actin Disassembly in Pupal Epidermal Cells Genetics, August 1, 2007; 176(4): 2223 - 2234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Assa-Kunik, I. L. Torres, E. D. Schejter, D. S. Johnston, and B.-Z. Shilo Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways Development, March 15, 2007; 134(6): 1161 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Miano, X. Long, and K. Fujiwara Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus Am J Physiol Cell Physiol, January 1, 2007; 292(1): C70 - C81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, D. K. Khadka, W. Liu, R. Bharti, L. W. Runnels, I. B. Dawid, and R. Habas Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation Development, November 1, 2006; 133(21): 4219 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ding, A. Lambrechts, M. Parepally, and P. Roy Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis J. Cell Sci., October 1, 2006; 119(19): 4127 - 4137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Frank, R. Hopmann, M. Lenartowska, and K. G. Miller Capping Protein and the Arp2/3 Complex Regulate Nonbundle Actin Filament Assembly to Indirectly Control Actin Bundle Positioning during Drosophila melanogaster Bristle Development Mol. Biol. Cell, September 1, 2006; 17(9): 3930 - 3939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Shapiro and K. V. Anderson Drosophila Ik2, a member of the I{kappa}B kinase family, is required for mRNA localization during oogenesis Development, April 15, 2006; 133(8): 1467 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. O. Dean, S. L. Rogers, N. Stuurman, R. D. Vale, and J. A. Spudich Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis PNAS, September 20, 2005; 102(38): 13473 - 13478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He, K. Emoto, X. Fang, N. Ren, X. Tian, Y.-N. Jan, and P. N. Adler Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases Mol. Biol. Cell, September 1, 2005; 16(9): 4139 - 4152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Serbus, B.-J. Cha, W. E. Theurkauf, and W. M. Saxton Dynein and the actin cytoskeleton control kinesin-driven cytoplasmic streaming in Drosophila oocytes Development, August 15, 2005; 132(16): 3743 - 3752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Obermann, I. Raabe, M. Balvers, B. Brunswig, W. Schulze, and C. Kirchhoff Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation Mol. Hum. Reprod., January 1, 2005; 11(1): 53 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wittenmayer, B. Jandrig, M. Rothkegel, K. Schluter, W. Arnold, W. Haensch, S. Scherneck, and B. M. Jockusch Tumor Suppressor Activity of Profilin Requires a Functional Actin Binding Site Mol. Biol. Cell, April 1, 2004; 15(4): 1600 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Da Silva, M. Medina, C. Zuliani, A. Di Nardo, W. Witke, and C. G. Dotti RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability J. Cell Biol., September 29, 2003; 162(7): 1267 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Rogers, U. Wiedemann, N. Stuurman, and R. D. Vale Molecular requirements for actin-based lamella formation in Drosophila S2 cells J. Cell Biol., September 15, 2003; 162(6): 1079 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McDonald, E. M. Pinheiro, and D. J. Montell PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman Development, August 1, 2003; 130(15): 3469 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Kovar, J. R. Kuhn, A. L. Tichy, and T. D. Pollard The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin J. Cell Biol., June 9, 2003; 161(5): 875 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Johnson and D. Van Vactor Receptor Protein Tyrosine Phosphatases in Nervous System Development Physiol Rev, January 1, 2003; 83(1): 1 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hopmann and K. G. Miller A Balance of Capping Protein and Profilin Functions Is Required to Regulate Actin Polymerization in Drosophila Bristle Mol. Biol. Cell, January 1, 2003; 14(1): 118 - 128. [Abstract] [Full Text]
|
|
|
|
|
|
T. F. Satterfield, S. M. Jackson, and L. J. Pallanck A Drosophila Homolog of the Polyglutamine Disease Gene SCA2 Is a Dosage-Sensitive Regulator of Actin Filament Formation Genetics, December 1, 2002; 162(4): 1687 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Ji, M. Haghnia, C. Trusty, L. S. B. Goldstein, and G. Schubiger A Genetic Screen for Suppressors and Enhancers of the Drosophila Cdk1-Cyclin B Identifies Maternal Factors That Regulate Microtubule and Microfilament Stability Genetics, November 1, 2002; 162(3): 1179 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Somma, B. Fasulo, G. Cenci, E. Cundari, and M. Gatti Molecular Dissection of Cytokinesis by RNA Interference in Drosophila Cultured Cells Mol. Biol. Cell, July 1, 2002; 13(7): 2448 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Hardiman, R. Brewster, S. M. Khan, M. Deo, and R. Bodmer The bereft Gene, a Potential Target of the Neural Selector Gene cut, Contributes to Bristle Morphogenesis Genetics, May 1, 2002; 161(1): 231 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Schnorr, R. Holdcraft, B. Chevalier, and C. A. Berg Ras1 Interacts With Multiple New Signaling and Cytoskeletal Loci in Drosophila Eggshell Patterning and Morphogenesis Genetics, October 1, 2001; 159(2): 609 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Battye, A. Stevens, R. L. Perry, and J. R. Jacobs Repellent Signaling by Slit Requires the Leucine-Rich Repeats J. Neurosci., June 15, 2001; 21(12): 4290 - 4298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ramachandran, H. E.M. Christensen, Y. Ishimaru, C.-H. Dong, W. Chao-Ming, A. L. Cleary, and N.-H. Chua Profilin Plays a Role in Cell Elongation, Cell Shape Maintenance, and Flowering in Arabidopsis Plant Physiology, December 1, 2000; 124(4): 1637 - 1647. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Hummel, K. Leifker, and C. Klämbt The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization Genes & Dev., April 1, 2000; 14(7): 863 - 873. [Abstract] [Full Text]
|
|
|
|
|
|
K Afshar, B Stuart, and S. Wasserman Functional analysis of the Drosophila diaphanous FH protein in early embryonic development Development, January 5, 2000; 127(9): 1887 - 1897. [Abstract] [PDF]
|
|
|
|
|
|
M Geese, K Schluter, M Rothkegel, B. Jockusch, J Wehland, and A. Sechi Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed J. Cell Sci., January 4, 2000; 113(8): 1415 - 1426. [Abstract] [PDF]
|
|
|
|
 |
|
 D. B. Szymanski, M. D. Marks, and S. M. Wick Organized F-Actin Is Essential for Normal Trichome Morphogenesis in Arabidopsis PLANT CELL, December 1, 1999; 11(12): 2331 - 2348. [Abstract] [Full Text]
|
|
|
|
|
|
M.-g. Li, M. Serr, K. Edwards, S. Ludmann, D. Yamamoto, L. G. Tilney, C. M. Field, and T. S. Hays Filamin Is Required for Ring Canal Assembly and Actin Organization during Drosophila Oogenesis J. Cell Biol., September 6, 1999; 146(5): 1061 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Jackson and C. A. Berg Soma-to-Germline Interactions During Drosophila Oogenesis Are Influenced by Dose-Sensitive Interactions Between cut and the Genes cappuccino, ovarian tumor and agnostic Genetics, September 1, 1999; 153(1): 289 - 303. [Abstract] [Full Text]
|
|
|
|
|
|
K. Purcell and S. Artavanis-Tsakonas The Developmental Role of warthog, the Notch Modifier Encoding Drab6 J. Cell Biol., August 23, 1999; 146(4): 731 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sawamoto, P. Winge, S. Koyama, Y. Hirota, C. Yamada, S. Miyao, S. Yoshikawa, M.-h. Jin, A. Kikuchi, and H. Okano The Drosophila Ral GTPase Regulates Developmental Cell Shape Changes through the Jun NH2-terminal Kinase Pathway J. Cell Biol., July 26, 1999; 146(2): 361 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Ahern-Djamali, C. Bachmann, P. Hua, S. K. Reddy, A. S. Kastenmeier, U. Walter, and F. M. Hoffmann Identification of profilin and src homology 3 domains as binding partners for Drosophila Enabled PNAS, April 27, 1999; 96(9): 4977 - 4982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Karakesisoglou, K.-P. Janssen, L. Eichinger, A. A. Noegel, and M. Schleicher Identification of a Suppressor of the Dictyostelium Profilin-minus Phenotype as a CD36/LIMP-II Homologue J. Cell Biol., April 5, 1999; 145(1): 167 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gonczy, H. Schnabel, T. Kaletta, A. D. Amores, T. Hyman, and R. Schnabel Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis J. Cell Biol., March 8, 1999; 144(5): 927 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Mathur, P Spielhofer, B Kost, and N Chua The actin cytoskeleton is required to elaborate and maintain spatial patterning during trichome cell morphogenesis in Arabidopsis thaliana Development, January 12, 1999; 126(24): 5559 - 5568. [Abstract] [PDF]
|
|
|
|
|
|
D. Kaiser, V. Vinson, D. Murphy, and T. Pollard Profilin is predominantly associated with monomeric actin in Acanthamoeba J. Cell Sci., January 11, 1999; 112(21): 3779 - 3790. [Abstract] [PDF]
|
|
|
|
|
|
S Grieshaber and N. Petersen The Drosophila forked protein induces the formation of actin fiber bundles in vertebrate cells J. Cell Sci., January 7, 1999; 112(13): 2203 - 2211. [Abstract] [PDF]
|
|
|
|
|
|
R Battye, A Stevens, and J. Jacobs Axon repulsion from the midline of the Drosophila CNS requires slit function Development, January 6, 1999; 126(11): 2475 - 2481. [Abstract] [PDF]
|
|
|
|
|
|
B. A. Hassan, S. N. Prokopenko, S. Breuer, B. Zhang, A. Paululat, and H. J. Bellen skittles, a Drosophila Phosphatidylinositol 4-Phosphate 5-Kinase, Is Required for Cell Viability, Germline Development and Bristle Morphology, But Not for Neurotransmitter Release Genetics, December 1, 1998; 150(4): 1527 - 1537. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Giansanti, S. Bonaccorsi, B. Williams, E. V. Williams, C. Santolamazza, M. L. Goldberg, and M. Gatti Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis Genes & Dev., February 1, 1998; 12(3): 396 - 410. [Abstract] [Full Text]
|
|
|
|
|
|
K Schluter, M Schleicher, and B. Jockusch Effects of single amino acid substitutions in the actin-binding site on the biological activity of bovine profilin I J. Cell Sci., January 11, 1998; 111(22): 3261 - 3273. [Abstract] [PDF]
|
|
|
|
|
|
J. Fabrizio, G Hime, S. Lemmon, and C Bazinet Genetic dissection of sperm individualization in Drosophila melanogaster Development, January 5, 1998; 125(10): 1833 - 1843. [Abstract] [PDF]
|
|
|
|
|
|
C. Dye, J. Lee, R. Atkinson, R Brewster, P. Han, and H. Bellen The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein Development, January 5, 1998; 125(10): 1845 - 1856. [Abstract] [PDF]
|
|
|
|
|
|
P. Jordan and R. Karess Myosin Light Chain-activating Phosphorylation Sites Are Required for Oogenesis in Drosophila J. Cell Biol., December 29, 1997; 139(7): 1805 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jackson and K Blochlinger cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis Development, January 9, 1997; 124(18): 3663 - 3672. [Abstract] [PDF]
|
|
|
|
|
|
P Gonczy and S DiNardo The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis Development, January 8, 1996; 122(8): 2437 - 2447. [Abstract] [PDF]
|
|
|
|
|
|
L Manseau, J Calley, and H Phan Profilin is required for posterior patterning of the Drosophila oocyte Development, January 7, 1996; 122(7): 2109 - 2116. [Abstract] [PDF]
|
|
|
|
|
|
M Rothkegel, O Mayboroda, M Rohde, C Wucherpfennig, R Valenta, and B. Jockusch Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells J. Cell Sci., January 1, 1996; 109(1): 83 - 90. [Abstract] [PDF]
|
|
|
|
 |
|
 R. H. Sohn, J. Chen, K. S. Koblan, P. F. Bray, and P. J. Goldschmidt-Clermont Localization of a Binding Site for Phosphatidylinositol 4,5-Bisphosphate on Human Profilin J. Biol. Chem., September 8, 1995; 270(36): 21114 - 21120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Wheatley, S Kulkarni, and R Karess Drosophila nonmuscle myosin II is required for rapid cytoplasmic transport during oogenesis and for axial nuclear migration in early embryos Development, January 6, 1995; 121(6): 1937 - 1946. [Abstract] [PDF]
|
|
|
|
 |
|
 L Cooley and W. Theurkauf Cytoskeletal functions during Drosophila oogenesis Science, October 28, 1994; 266(5185): 590 - 596. [Abstract] [PDF]
|
|
|
|
|
|
W. Witke, J. D. Sutherland, A. Sharpe, M. Arai, and D. J. Kwiatkowski Profilin I is essential for cell survival and cell division in early mouse development PNAS, March 27, 2001; 98(7): 3832 - 3836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wahlstrom, M. Vartiainen, L. Yamamoto, P. K. Mattila, P. Lappalainen, and T. I. Heino Twinfilin is required for actin-dependent developmental processes in Drosophila J. Cell Biol., November 26, 2001; 155(5): 787 - 796. [Abstract] [Full Text] [PDF]
|
|
