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Development, Vol 120, Issue 4 947-956, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
H Lin, L Yue and AC Spradling
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA.
Oogenesis in Drosophila takes place within germline cysts that support polarized transport through ring canals interconnecting their 15 nurse cells and single oocyte. Developing cystocytes are spanned by a large cytoplasmic structure known as the fusome that has been postulated to help form ring canals and determine the pattern of nurse cell-oocyte interconnections. We identified the adducin-like hts product and alpha-spectrin as molecular components of fusomes, discovered a related structure in germline stem cells and documented regular associations between fusomes and cystocyte centrosomes. hts mutations completely eliminated fusomes, causing abnormal cysts containing a reduced number of cells to form. Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions.
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M. Pepling and A. Spradling Female mouse germ cells form synchronously dividing cysts Development, January 9, 1998; 125(17): 3323 - 3328. [Abstract] [PDF]
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M de Cuevas and A. Spradling Morphogenesis of the Drosophila fusome and its implications for oocyte specification Development, January 8, 1998; 125(15): 2781 - 2789. [Abstract] [PDF]
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S Styhler, A Nakamura, A Swan, B Suter, and P Lasko vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development Development, January 5, 1998; 125(9): 1569 - 1578. [Abstract] [PDF]
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A Forbes and R Lehmann Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells Development, January 2, 1998; 125(4): 679 - 690. [Abstract] [PDF]
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