spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goulding, M.
Right arrow Articles by Paquette, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goulding, M.
Right arrow Articles by Paquette, A. J.

Development, Vol 120, Issue 4 957-971, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Regulation of Pax-3 expression in the dermomyotome and its role in muscle development

M Goulding, A Lumsden and AJ Paquette
Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037, USA.

The segmented mesoderm in vertebrates gives rise to a variety of cell types in the embryo including the axial skeleton and muscle. A number of transcription factors containing a paired domain (Pax proteins) are expressed in the segmented mesoderm during embryogenesis. These include Pax-3 and a closely related gene, Pax-7, both of which are expressed in the segmental plate and in the dermomyotome. In this paper, we show that signals from the notochord pattern the expression of Pax-3, Pax-7 and Pax-9 in somites and the subsequent differentiation of cell types that arise from the somitic mesoderm. We directly assess the role of the Pax-3 gene in the differentiation of cell types derived from the dermomyotome by analyzing the development of muscle in splotch mouse embryos which lack a functional Pax-3 gene. A population of Pax-3-expressing cells derived from the dermomyotome that normally migrate into the limb are absent in homozygous splotch embryos and, as a result, limb muscles are lost. No abnormalities were detected in the trunk musculature of splotch embryos indicating that Pax-3 is necessary for the development of the limb but not trunk muscle.


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
R. B. White and M. R. Ziman
Genome-wide discovery of Pax7 target genes during development
Physiol Genomics, March 10, 2008; 33(1): 41 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. K. Linask, K. Knudsen, and M. George-Weinstein
Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage
J. Cell Biol., August 9, 2007; 178(4): 649 - 660.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
H. C. Olguin, Z. Yang, S. J. Tapscott, and B. B. Olwin
Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination
J. Cell Biol., June 21, 2007; 177(5): 769 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. P. Shih, M. K. Gross, and C. Kioussi
Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch
PNAS, April 3, 2007; 104(14): 5907 - 5912.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Li, R. B. Hough, and J. Piatigorsky
Tissue-specific activity of the blind mole rat and the two nucleotide-mutated mouse {alpha}B-crystallin promoter in transgenic mice
PNAS, February 20, 2007; 104(8): 2608 - 2613.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Gerhart, J. Elder, C. Neely, J. Schure, T. Kvist, K. Knudsen, and M. George-Weinstein
MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo
J. Cell Biol., October 23, 2006; 175(2): 283 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Shi and D. J. Garry
Muscle stem cells in development, regeneration, and disease.
Genes & Dev., July 1, 2006; 20(13): 1692 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. S. Zammit, F. Relaix, Y. Nagata, A. P. Ruiz, C. A. Collins, T. A. Partridge, and J. R. Beauchamp
Pax7 and myogenic progression in skeletal muscle satellite cells
J. Cell Sci., May 1, 2006; 119(9): 1824 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Schienda, K. A. Engleka, S. Jun, M. S. Hansen, J. A. Epstein, C. J. Tabin, L. M. Kunkel, and G. Kardon
Somitic origin of limb muscle satellite and side population cells
PNAS, January 24, 2006; 103(4): 945 - 950.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
F. Relaix, D. Montarras, S. Zaffran, B. Gayraud-Morel, D. Rocancourt, S. Tajbakhsh, A. Mansouri, A. Cumano, and M. Buckingham
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
J. Cell Biol., January 3, 2006; 172(1): 91 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. Kuang, S. B. Charge, P. Seale, M. Huh, and M. A. Rudnicki
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
J. Cell Biol., January 3, 2006; 172(1): 103 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
E. Vasyutina, J. Stebler, B. Brand-Saberi, S. Schulz, E. Raz, and C. Birchmeier
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
Genes & Dev., September 15, 2005; 19(18): 2187 - 2198.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Grifone, J. Demignon, C. Houbron, E. Souil, C. Niro, M. J. Seller, G. Hamard, and P. Maire
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo
Development, May 1, 2005; 132(9): 2235 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Apuzzo, A. Abdelhakim, A. S. Fortin, and P. Gros
Cross-talk between the Paired Domain and the Homeodomain of Pax3: DNA BINDING BY EACH DOMAIN CAUSES A STRUCTURAL CHANGE IN THE OTHER DOMAIN, SUPPORTING INTERDEPENDENCE FOR DNA BINDING
J. Biol. Chem., August 6, 2004; 279(32): 33601 - 33612.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Grimaldi, G. Tettamanti, B. L. Martin, W. Gaffield, M. E. Pownall, and S. M. Hughes
Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis
Development, July 15, 2004; 131(14): 3249 - 3262.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Parsons, D. P. Millay, B. J. Wilkins, O. F. Bueno, G. L. Tsika, J. R. Neilson, C. M. Liberatore, K. E. Yutzey, G. R. Crabtree, R. W. Tsika, et al.
Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy
J. Biol. Chem., June 18, 2004; 279(25): 26192 - 26200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Petropoulos, P. J. Gianakopoulos, A. G. Ridgeway, and I. S. Skerjanc
Disruption of Meox or Gli Activity Ablates Skeletal Myogenesis in P19 Cells
J. Biol. Chem., June 4, 2004; 279(23): 23874 - 23881.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Bussen, M. Petry, K. Schuster-Gossler, M. Leitges, A. Gossler, and A. Kispert
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
Genes & Dev., May 15, 2004; 18(10): 1209 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
F. Relaix, D. Rocancourt, A. Mansouri, and M. Buckingham
Divergent functions of murine Pax3 and Pax7 in limb muscle development
Genes & Dev., May 1, 2004; 18(9): 1088 - 1105.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
F. Relaix, M. Polimeni, D. Rocancourt, C. Ponzetto, B. W. Schafer, and M. Buckingham
The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo
Genes & Dev., December 1, 2003; 17(23): 2950 - 2965.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Laclef, G. Hamard, J. Demignon, E. Souil, C. Houbron, and P. Maire
Altered myogenesis in Six1-deficient mice
Development, May 15, 2003; 130(10): 2239 - 2252.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. S. Cachaco, S. M. Chuva de Sousa Lopes, I. Kuikman, F. Bajanca, K. Abe, C. Baudoin, A. Sonnenberg, C. L. Mummery, and S. Thorsteinsdottir
Knock-in of integrin {beta}1D affects primary but not secondary myogenesis in mice
Development, April 15, 2003; 130(8): 1659 - 1671.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. Lagutina, S. J. Conway, J. Sublett, and G. C. Grosveld
Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors
Mol. Cell. Biol., October 15, 2002; 22(20): 7204 - 7216.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Marics, F. Padilla, J.-F. Guillemot, M. Scaal, and C. Marcelle
FGFR4 signaling is a necessary step in limb muscle differentiation
Development, January 10, 2002; 129(19): 4559 - 4569.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. C. Mootoosamy and S. Dietrich
Distinct regulatory cascades for head and trunk myogenesis
Development, January 2, 2002; 129(3): 573 - 583.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. H. Simon, H. Saueressig, W. Wurst, M. D. Goulding, and D. D. M. O'Leary
Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes
J. Neurosci., May 1, 2001; 21(9): 3126 - 3134.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y Cinnamon, N Kahane, I Bachelet, and C Kalcheim
The sub-lip domain--a distinct pathway for myotome precursors that demonstrate rostral-caudal migration
Development, January 2, 2001; 128(3): 341 - 351.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
K. Ayyanathan, W. J. Fredericks, C. Berking, M. Herlyn, C. Balakrishnan, E. Gunther, and F. J. Rauscher III
Hormone-dependent Tumor Regression in Vivo by an Inducible Transcriptional Repressor Directed at the PAX3-FKHR Oncogene
Cancer Res., October 1, 2000; 60(20): 5803 - 5814.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
D. Houzelstein, Y. Cheraud, G. Auda-Boucher, J. Fontaine-Perus, and B. Robert
The expression of the homeobox gene Msx1 reveals two populations of dermal progenitor cells originating from the somites
Development, May 15, 2000; 127(10): 2155 - 2164.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Dockter and C. P. Ordahl
Dorsoventral axis determination in the somite: a re-examination
Development, May 15, 2000; 127(10): 2201 - 2206.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Sela-Donenfeld and C Kalcheim
Inhibition of noggin expression in the dorsal neural tube by somitogenesis: a mechanism for coordinating the timing of neural crest emigration
Development, January 11, 2000; 127(22): 4845 - 4854.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Epstein, J Li, D Lang, F Chen, C. Brown, F Jin, M. Lu, M Thomas, E Liu, A Wessels, et al.
Migration of cardiac neural crest cells in Splotch embryos
Development, January 5, 2000; 127(9): 1869 - 1878.
[Abstract] [PDF]

Home page
 DevelopmentHome page
W. Denetclaw and C. Ordahl
The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos
Development, January 2, 2000; 127(4): 893 - 905.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M. Gross, L Moran-Rivard, T Velasquez, M. Nakatsu, K Jagla, and M Goulding
Lbx1 is required for muscle precursor migration along a lateral pathway into the limb
Development, January 1, 2000; 127(2): 413 - 424.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Brohmann, K Jagla, and C Birchmeier
The role of Lbx1 in migration of muscle precursor cells
Development, January 1, 2000; 127(2): 437 - 445.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
T. A. Heanue, R. Reshef, R. J. Davis, G. Mardon, G. Oliver, S. Tomarev, A. B. Lassar, and C. J. Tabin
Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation
Genes & Dev., December 15, 1999; 13(24): 3231 - 3243.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
L. De Angelis, L. Berghella, M. Coletta, L. Lattanzi, M. Zanchi, M. Gabriella , Cusella-, C. Ponzetto, and G. Cossu
Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration
J. Cell Biol., November 15, 1999; 147(4): 869 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. G. Barr, J. C. Fitzgerald, J. P. Ginsberg, M. L. Vanella, R. J. Davis, and J. L. Bennicelli
Predominant Expression of Alternative PAX3 and PAX7 Forms in Myogenic and Neural Tumor Cell Lines
Cancer Res., November 1, 1999; 59(21): 5443 - 5448.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H Peters, B Wilm, N Sakai, K Imai, R Maas, and R Balling
Pax1 and Pax9 synergistically regulate vertebral column development
Development, January 12, 1999; 126(23): 5399 - 5408.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
C Sanz, Y Leon, S Canon, L Alvarez, F Giraldez, and I Varela-Nieto
Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis
J. Cell Sci., January 11, 1999; 112(22): 3967 - 3974.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Scaal, A Bonafede, V Dathe, M Sachs, G Cann, B Christ, and B Brand-Saberi
SF/HGF is a mediator between limb patterning and muscle development
Development, January 11, 1999; 126(21): 4885 - 4893.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Bendall, J Ding, G Hu, M. Shen, and C Abate-Shen
Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors
Development, January 11, 1999; 126(22): 4965 - 4976.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Cinnamon, N Kahane, and C Kalcheim
Characterization of the early development of specific hypaxial muscles from the ventrolateral myotome
Development, January 10, 1999; 126(19): 4305 - 4315.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Borycki, B Brunk, S Tajbakhsh, M Buckingham, C Chiang, and C. Emerson
Sonic hedgehog controls epaxial muscle determination through Myf5 activation
Development, January 9, 1999; 126(18): 4053 - 4063.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Li, K. Liu, F Jin, M. Lu, and J. Epstein
Transgenic rescue of congenital heart disease and spina bifida in Splotch mice
Development, January 6, 1999; 126(11): 2495 - 2503.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Houzelstein, G Auda-Boucher, Y Cheraud, T Rouaud, I Blanc, S Tajbakhsh, M. Buckingham, J Fontaine-Perus, and B Robert
The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb
Development, January 6, 1999; 126(12): 2689 - 2701.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Dietrich, F Abou-Rebyeh, H Brohmann, F Bladt, E Sonnenberg-Riethmacher, T Yamaai, A Lumsden, B Brand-Saberi, and C Birchmeier
The role of SF/HGF and c-Met in the development of skeletal muscle
Development, January 4, 1999; 126(8): 1621 - 1629.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Borycki, J Li, F Jin, C. Emerson, and J. Epstein
Pax3 functions in cell survival and in pax7 regulation
Development, January 4, 1999; 126(8): 1665 - 1674.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Kenny, L. W. Jurata, Y. Saga, and G. N. Gill
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
PNAS, September 15, 1998; 95(19): 11257 - 11262.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
M. GEORGE-WEINSTEIN, J. GERHART, M. MATTIACCI-PAESSLER, E. SIMAK, J. BLITZ, R. REED, and K. KNUDSEN
The Roles of Stably Committed and Uncommitted Cells in Establishing Tissues of the Somite
Ann. N.Y. Acad. Sci., April 15, 1998; 842(1): 16 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. Reshef, M. Maroto, and A. B. Lassar
Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression
Genes & Dev., February 1, 1998; 12(3): 290 - 303.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
N Kahane, Y Cinnamon, and C Kalcheim
The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development
Development, January 11, 1998; 125(21): 4259 - 4271.
[Abstract] [PDF]

Home page
 DevelopmentHome page
G Kardon
Muscle and tendon morphogenesis in the avian hind limb
Development, January 10, 1998; 125(20): 4019 - 4032.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Hacker and S Guthrie
A distinct developmental programme for the cranial paraxial mesoderm in the chick embryo
Development, January 9, 1998; 125(17): 3461 - 3472.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Watanabe, D Duprez, A. Monsoro-Burq, C Vincent, and N. Le Douarin
Two domains in vertebral development: antagonistic regulation by SHH and BMP4 proteins
Development, January 7, 1998; 125(14): 2631 - 2639.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Dietrich, F. Schubert, C Healy, P. Sharpe, and A Lumsden
Specification of the hypaxial musculature
Development, January 6, 1998; 125(12): 2235 - 2249.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Yamamoto, Y Gotoh, K Tamura, M Tanaka, A Kawakami, H Ide, and A Kuroiwa
Coordinated expression of Hoxa-11 and Hoxa-13 during limb muscle patterning
Development, January 4, 1998; 125(7): 1325 - 1335.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Duprez, C Fournier-Thibault, and N Le Douarin
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
Development, January 2, 1998; 125(3): 495 - 505.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
S. J Conway, D. J Henderson, M. L Kirby, R. H Anderson, and A. J Copp
Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse
Cardiovasc Res, November 1, 1997; 36(2): 163 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P.-X. Xu, J. Cheng, J. A. Epstein, and R. L. Maas
Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function
PNAS, October 28, 1997; 94(22): 11974 - 11979.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. S. Blagden, P. D. Currie, P. W. Ingham, and S. M. Hughes
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog
Genes & Dev., September 1, 1997; 11(17): 2163 - 2175.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Williams and C. Ordahl
Emergence of determined myotome precursor cells in the somite
Development, January 12, 1997; 124(24): 4983 - 4997.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Burrill, L Moran, M. Goulding, and H Saueressig
PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development
Development, January 11, 1997; 124(22): 4493 - 4503.
[Abstract] [PDF]

Home page
 DevelopmentHome page
E Hirsinger, D Duprez, C Jouve, P Malapert, J Cooke, and O Pourquie
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite