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Development, Vol 120, Issue 5 1035-1047, Copyright © 1994 by Company of Biologists


JOURNAL ARTICLES

The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions

MA Herman and HR Horvitz
Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

The generation and orientation of cellular and organismic polarity are fundamental aspects of development. Mutations in the gene lin-44 of the nematode Caenorhabditis elegans reverse both the relative positions of specific sister cells and the apparent polarities of these cells. Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells.


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© The Company of Biologists Ltd 1994