|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 5 1059-1070, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
WQ Gao and ME Hatten
Rockefeller University, New York, NY 10021-6399.
After implantation into the external germinal layer of early postnatal cerebellum, primary external germinal layer progenitor cells gave rise exclusively to granule neurons. In contrast, all major classes of cerebellar cells were observed following implantation of embryonic day 13 cerebellar precursor cells into the external germinal layer. These results suggest that granule cells arise from precursors with a restricted potential. In contrast to results with the primary external germinal layer population, cell lines established from external germinal layer cells, by infection with a retrovirus containing the SV40 large T-antigen oncogene, gave rise to several cerebellar cell types upon implantation. These included granule neurons, one subclass of stellate interneurons, Golgi cells, Bergmann glia and astrocytes. From these results, we conclude that early postnatal external germinal layer progenitors are normally fated to a granule cell identity and that expression of the SV40 large T-antigen oncogene subverts mechanisms that control granule neuron fate.
This article has been cited by other articles:
|
|
 |
|
  X. Fan and C. G. Eberhart Medulloblastoma Stem Cells J. Clin. Oncol., June 10, 2008; 26(17): 2821 - 2827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Carletti and F. Rossi Neurogenesis in the Cerebellum Neuroscientist, February 1, 2008; 14(1): 91 - 100. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Leto, B. Carletti, I. M. Williams, L. Magrassi, and F. Rossi Different Types of Cerebellar GABAergic Interneurons Originate from a Common Pool of Multipotent Progenitor Cells. J. Neurosci., November 8, 2006; 26(45): 11682 - 11694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. McManus and J. A. Golden Topical Review: Neuronal Migration in Developmental Disorders J Child Neurol, April 1, 2005; 20(4): 280 - 286. [Abstract] [PDF]
|
|
|
|
|
|
M. F. McManus and J. A. Golden Topical Review: Neuronal Migration in Developmental Disorders J Child Neurol, March 1, 2004; 19(3): 280 - 286. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Okano-Uchida, T. Himi, Y. Komiya, and Y. Ishizaki Cerebellar granule cell precursors can differentiate into astroglial cells PNAS, February 3, 2004; 101(5): 1211 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moreau-Fauvarque, A. Kumanogoh, E. Camand, C. Jaillard, G. Barbin, I. Boquet, C. Love, E. Y. Jones, H. Kikutani, C. Lubetzki, et al. The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion J. Neurosci., October 8, 2003; 23(27): 9229 - 9239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Carletti, P. Grimaldi, L. Magrassi, and F. Rossi Specification of Cerebellar Progenitors After Heterotopic-Heterochronic Transplantation to the Embryonic CNS In Vivo and In Vitro J. Neurosci., August 15, 2002; 22(16): 7132 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Lin, L. Cai, and C. L. Cepko The External Granule Layer of the Developing Chick Cerebellum Generates Granule Cells and Cells of the Isthmus and Rostral Hindbrain J. Neurosci., January 1, 2001; 21(1): 159 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Bhatt, T. Tomoda, Y. Fang, and M. E. Hatten Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons Genes & Dev., September 1, 2000; 14(17): 2216 - 2228. [Abstract] [Full Text]
|
|
|
|
 |
|
 S Alcantara, M Ruiz, F De Castro, E Soriano, and C Sotelo Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system Development, January 4, 2000; 127(7): 1359 - 1372. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Fricker, M. K. Carpenter, C. Winkler, C. Greco, M. A. Gates, and A. Bjorklund Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain J. Neurosci., July 15, 1999; 19(14): 5990 - 6005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Huard, C. Forster, M. Carter, P Sicinski, and M. Ross Cerebellar histogenesis is disturbed in mice lacking cyclin D2 Development, January 5, 1999; 126(9): 1927 - 1935. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Lin and C. L. Cepko Granule Cell Raphes and Parasagittal Domains of Purkinje Cells: Complementary Patterns in the Developing Chick Cerebellum J. Neurosci., November 15, 1998; 18(22): 9342 - 9353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Snyder Review : Neural Stem-Like Cells: Developmental Lessons with Therapeutic Potential Neuroscientist, November 1, 1998; 4(6): 408 - 425. [Abstract] [PDF]
|
|
|
|
|
|
A. Helms and J. Johnson Progenitors of dorsal commissural interneurons are defined by MATH1 expression Development, January 3, 1998; 125(5): 919 - 928. [Abstract] [PDF]
|
|
|
|
|
|
J. Aruga, O. Minowa, H. Yaginuma, J. Kuno, T. Nagai, T. Noda, and K. Mikoshiba Mouse Zic1 Is Involved in Cerebellar Development J. Neurosci., January 1, 1998; 18(1): 284 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zheng and W.-Q. Gao Analysis of Rat Vestibular Hair Cell Development and Regeneration Using Calretinin as an Early Marker J. Neurosci., November 1, 1997; 17(21): 8270 - 8282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rosario, B. Yandava, B Kosaras, D Zurakowski, R. Sidman, and E. Snyder Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action Development, January 11, 1997; 124(21): 4213 - 4224. [Abstract] [PDF]
|
|
|
|
|
|
X. Yang, R Zhong, and N Heintz Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49 Development, January 2, 1996; 122(2): 555 - 566. [Abstract] [PDF]
|
|
|
|
|
|
G Fishell Striatal precursors adopt cortical identities in response to local cues Development, January 3, 1995; 121(3): 803 - 812. [Abstract] [PDF]
|
|
