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Development, Vol 120, Issue 5 1071-1083, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
SK Das, XN Wang, BC Paria, D Damm, JA Abraham, M Klagsbrun, GK Andrews and SK Dey
Department of Physiology, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City 66160-7338.
Heparin-binding EGF-like growth factor (HB-EGF) is a newly discovered member of the EGF family of growth factors. HB-EGF can bind to two loci on cell surfaces, heparan sulphate proteoglycans and EGF-receptor (EGF-R), and either one or both of these interactions could play a role in cell-cell interactions. In the rodent, increased endometrial vascular permeability at the site of blastocyst apposition is considered to be an earliest discernible prerequisite event in the process of implantation and this event coincides with the initial attachment reaction between the blastocyst trophectoderm and uterine luminal epithelium. This investigation demonstrates that the HB-EGF gene is expressed in the mouse uterine luminal epithelium surrounding the blastocyst 6-7 hours before the attachment reaction that occurs at 2200-2300 hours on day 4 of pregnancy. It was further demonstrated that this gene is not expressed in the luminal epithelium at the site of the blastocyst apposition during the progesterone-maintained delayed implantation, but is readily induced in the luminal epithelium surrounding an activated blastocyst after termination of the delay by an estrogen injection. In vitro studies showed that HB-EGF induced blastocyst EGF-R autophosphorylation, and promoted blastocyst growth, zona-hatching and trophoblast outgrowth. These results suggest possible interactions between the uterine HB-EGF and blastocyst EGF-R very early in the process of implantation, earlier than any other embryo-uterine interactions defined to date at the molecular level.
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K. Y Lee and F. J DeMayo Animal models of implantation Reproduction, December 1, 2004; 128(6): 679 - 695. [Abstract] [Full Text] [PDF] |
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X. Hou, Y. Tan, M. Li, S. K. Dey, and S. K. Das Canonical Wnt Signaling Is Critical to Estrogen-Mediated Uterine Growth Mol. Endocrinol., December 1, 2004; 18(12): 3035 - 3049. [Abstract] [Full Text] [PDF] |
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N. Brown, K. Deb, B. C. Paria, S. K. Das, and J. Reese Embryo-Uterine Interactions via the Neuregulin Family of Growth Factors During Implantation in the Mouse Biol Reprod, December 1, 2004; 71(6): 2003 - 2011. [Abstract] [Full Text] [PDF] |
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R. Takazaki, Y. Shishido, R. Iwamoto, and E. Mekada Suppression of the Biological Activities of the Epidermal Growth Factor (EGF)-like Domain by the Heparin-binding Domain of Heparin-binding EGF-like Growth Factor J. Biol. Chem., November 5, 2004; 279(45): 47335 - 47343. [Abstract] [Full Text] [PDF] |
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O. A. Mohamed, D. Dufort, and H. J. Clarke Expression and Estradiol Regulation of Wnt Genes in the Mouse Blastocyst Identify a Candidate Pathway for Embryo-Maternal Signaling at Implantation Biol Reprod, August 1, 2004; 71(2): 417 - 424. [Abstract] [Full Text] [PDF] |
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X. Wang, Y. Su, K. Deb, M. Raposo, J. D. Morrow, J. Reese, and B. C. Paria Prostaglandin E2 Is a Product of Induced Prostaglandin-endoperoxide Synthase 2 and Microsomal-type Prostaglandin E Synthase at the Implantation Site of the Hamster J. Biol. Chem., July 16, 2004; 279(29): 30579 - 30587. [Abstract] [Full Text] [PDF] |
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T. Hamatani, T. Daikoku, H. Wang, H. Matsumoto, M. G. Carter, M. S. H. Ko, and S. K. Dey Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation PNAS, July 13, 2004; 101(28): 10326 - 10331. [Abstract] [Full Text] [PDF] |
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S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang Molecular Cues to Implantation Endocr. Rev., June 1, 2004; 25(3): 341 - 373. [Abstract] [Full Text] [PDF] |
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T. Daikoku, H. Song, Y. Guo, A. Riesewijk, S. Mosselman, S. K. Das, and S. K. Dey Uterine Msx-1 and Wnt4 Signaling Becomes Aberrant in Mice with the Loss of Leukemia Inhibitory Factor or Hoxa-10: Evidence for a Novel Cytokine-Homeobox-Wnt Signaling in Implantation Mol. Endocrinol., May 1, 2004; 18(5): 1238 - 1250. [Abstract] [Full Text] [PDF] |
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H. Wang, W.-g. Ma, L. Tejada, H. Zhang, J. D. Morrow, S. K. Das, and S. K. Dey Rescue of Female Infertility from the Loss of Cyclooxygenase-2 by Compensatory Up-regulation of Cyclooxygenase-1 Is a Function of Genetic Makeup J. Biol. Chem., March 12, 2004; 279(11): 10649 - 10658. [Abstract] [Full Text] [PDF] |
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H. Matsumoto, T. Daikoku, H. Wang, E. Sato, and S.K. Dey Differential Expression of Ezrin/Radixin/Moesin (ERM) and ERM-Associated Adhesion Molecules in the Blastocyst and Uterus Suggests Their Functions During Implantation Biol Reprod, March 1, 2004; 70(3): 729 - 736. [Abstract] [Full Text] [PDF] |
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X. Wang, H. Matsumoto, X. Zhao, S. K. Das, and B. C. Paria Embryonic signals direct the formation of tight junctional permeability barrier in the decidualizing stroma during embryo implantation J. Cell Sci., January 1, 2004; 117(1): 53 - 62. [Abstract] [Full Text] [PDF] |
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H. Takenobu, A. Yamazaki, M. Hirata, T. Umata, and E. Mekada The Stress- and Inflammatory Cytokine-induced Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor Is Mediated by p38 MAPK, Distinct from the 12-O-Tetradecanoylphorbol-13-acetate- and Lysophosphatidic Acid-induced Signaling Cascades J. Biol. Chem., May 2, 2003; 278(19): 17255 - 17262. [Abstract] [Full Text] [PDF] |
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R. Iwamoto, S. Yamazaki, M. Asakura, S. Takashima, H. Hasuwa, K. Miyado, S. Adachi, M. Kitakaze, K. Hashimoto, G. Raab, et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function PNAS, March 18, 2003; 100(6): 3221 - 3226. [Abstract] [Full Text] [PDF] |
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