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Development, Vol 120, Issue 7 1919-1928, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
FL Conlon, KM Lyons, N Takaesu, KS Barth, A Kispert, B Herrmann and EJ Robertson
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
The 413.d insertional mutation arrests mouse development shortly after gastrulation. nodal, a novel TGF beta-related gene, is closely associated with the locus. The present study provides direct evidence that the proviral insertion causes a loss of function mutation. nodal RNA is initially detected at day 5.5 in the primitive ectoderm. Concomitant with gastrulation, expression becomes restricted to the proximal posterior regions of the embryonic ectoderm. nodal RNA is also expressed in the primitive endoderm overlying the primitive streak. A few hours later, expression is strictly confined to the periphery of the mature node. Interestingly 413.d mutant embryos show no morphological evidence for the formation of a primitive streak. Nonetheless, about 25% of mutant embryos do form randomly positioned patches of cells of a posterior mesodermal character. Data presented in this report demonstrate the involvement of a TGF beta-related molecule in axis formation in mammals.
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S. Osada, Y Saijoh, A Frisch, C. Yeo, H Adachi, M Watanabe, M Whitman, H Hamada, and C. Wright Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1 Development, January 6, 2000; 127(11): 2503 - 2514. [Abstract] [PDF]
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J. Wells and D. Melton Early mouse endoderm is patterned by soluble factors from adjacent germ layers Development, January 4, 2000; 127(8): 1563 - 1572. [Abstract] [PDF]
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K Gritsman, W. Talbot, and A. Schier Nodal signaling patterns the organizer Development, January 3, 2000; 127(5): 921 - 932. [Abstract] [PDF]
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E Agius, M Oelgeschlager, O Wessely, C Kemp, and E. De Robertis Endodermal Nodal-related signals and mesoderm induction in Xenopus Development, January 3, 2000; 127(6): 1173 - 1183. [Abstract] [PDF]
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H. Adachi, Y. Saijoh, K. Mochida, S. Ohishi, H. Hashiguchi, A. Hirao, and H. Hamada Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer Genes & Dev., June 15, 1999; 13(12): 1589 - 1600. [Abstract] [Full Text]
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A. Ramsdell and H. Yost Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway Development, January 12, 1999; 126(23): 5195 - 5205. [Abstract] [PDF]
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M Kofron, T Demel, J Xanthos, J Lohr, B Sun, H Sive, S Osada, C Wright, C Wylie, and J Heasman Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors Development, January 12, 1999; 126(24): 5759 - 5770. [Abstract] [PDF]
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D Clements, R. Friday, and H. Woodland Mode of action of VegT in mesoderm and endoderm formation Development, January 11, 1999; 126(21): 4903 - 4911. [Abstract] [PDF]
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D Brown, D Wagner, X Li, J. Richardson, and E. Olson Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis Development, January 10, 1999; 126(19): 4317 - 4329. [Abstract] [PDF]
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Z Gu, E. Reynolds, J Song, H Lei, A Feijen, L Yu, W He, D. MacLaughlin, J van den Eijnden-van Raaij, P. Donahoe, et al. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo Development, January 6, 1999; 126(11): 2551 - 2561. [Abstract] [PDF]
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S. Osada and C. Wright Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis Development, January 6, 1999; 126(14): 3229 - 3240. [Abstract] [PDF]
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H Chang, D Huylebroeck, K Verschueren, Q Guo, M. Matzuk, and A Zwijsen Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects Development, January 4, 1999; 126(8): 1631 - 1642. [Abstract] [PDF]
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M. R. Rebagliati, R. Toyama, P. Haffter, and I. B. Dawid cyclops encodes a nodal-related factor involved in midline signaling PNAS, August 18, 1998; 95(17): 9932 - 9937. [Abstract] [Full Text] [PDF]
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C. A. Ferguson, A. S. Tucker, L. Christensen, A. L. Lau, M. M. Matzuk, and P. T. Sharpe Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition Genes & Dev., August 15, 1998; 12(16): 2636 - 2649. [Abstract] [Full Text]
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M. Weinstein, X. Yang, C. Li, X. Xu, J. Gotay, and C.-X. Deng Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2 PNAS, August 4, 1998; 95(16): 9378 - 9383. [Abstract] [Full Text] [PDF]
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Z. Gu, M. Nomura, B. B. Simpson, H. Lei, A. Feijen, J. van den Eijnden-van Raaij, P. K. Donahoe, and E. Li The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse Genes & Dev., March 15, 1998; 12(6): 844 - 857. [Abstract] [Full Text]
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A. Roebroek, L Umans, I. Pauli, E. Robertson, F van Leuven, W. Van de Ven, and D. Constam Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin Development, January 12, 1998; 125(24): 4863 - 4876. [Abstract] [PDF]
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S. Tang, P. Hoodless, Z Lu, M. Breitman, R. McInnes, J. Wrana, and M Buchwald The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development Development, January 5, 1998; 125(10): 1877 - 1887. [Abstract] [PDF]
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