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Development, Vol 120, Issue 7 2065-2075, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
W Wurst, AB Auerbach and AL Joyner
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada.
During mouse development, the homeobox-containing gene En-1 is specifically expressed across the mid-hindbrain junction, the ventral ectoderm of the limb buds, and in regions of the hindbrain, spinal cord, somites and somite-derived tissues. To address the function of En-1 during embryogenesis, we have generated mice homozygous for a targeted deletion of the En-1 homeobox. En-1 mutant mice died shortly after birth and exhibited multiple developmental defects. In the brains of newborn mutants, most of the colliculi and cerebellum were missing and the third and fourth cranial nerves were absent. A deletion of midhindbrain tissue was observed as early as 9.5 days of embryonic development and the phenotype resembles that previously reported for Wnt-1 mutant mice. In addition, patterning of the forelimb paws and sternum was disrupted, and the 13th ribs were truncated. The results of these studies suggest a cell autonomous role for En-1 in generation and/or survival of mid-hindbrain precursor cells and also a non-cell autonomous role in signalling normal development of the limbs and possibly sternum.
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R Wehr, A Mansouri, T de Maeyer, and P Gruss Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body Development, January 11, 1997; 124(22): 4447 - 4456. [Abstract] [PDF]
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J. Burrill, L Moran, M. Goulding, and H Saueressig PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development Development, January 11, 1997; 124(22): 4493 - 4503. [Abstract] [PDF]
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M Altabef, J. Clarke, and C Tickle Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb Development, January 11, 1997; 124(22): 4547 - 4556. [Abstract] [PDF]
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L Mathis, C Bonnerot, L Puelles, and J. Nicolas Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics Development, January 10, 1997; 124(20): 4089 - 4104. [Abstract] [PDF]
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K. Wassarman, M Lewandoski, K Campbell, A. Joyner, J. Rubenstein, S Martinez, and G. Martin Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function Development, January 8, 1997; 124(15): 2923 - 2934. [Abstract] [PDF]
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C Logan, A Hornbruch, I Campbell, and A Lumsden The role of Engrailed in establishing the dorsoventral axis of the chick limb Development, January 6, 1997; 124(12): 2317 - 2324. [Abstract] [PDF]
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L. Holland, M Kene, N. Williams, and N. Holland Sequence and embryonic expression of the amphioxus engrailed gene (AmphiEn): the metameric pattern of transcription resembles that of its segment-polarity homolog in Drosophila Development, January 5, 1997; 124(9): 1723 - 1732. [Abstract] [PDF]
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G. Mastick, N. Davis, G. Andrew, and S. Easter Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain Development, January 5, 1997; 124(10): 1985 - 1997. [Abstract] [PDF]
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P Kury, N Schaeren-Wiemers, and D Monard Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells Development, January 3, 1997; 124(6): 1251 - 1262. [Abstract] [PDF]
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 M. Lewandoski, E.N. Meyers, and G.R. Martin Analysis of Fgf8 Gene Function in Vertebrate Development Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 159 - 168. [Abstract] [PDF]
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W. Driever, L. Solnica-Krezel, S. Abdelilah, D. Meyer, and D. Stemple Genetic Analysis of Pattern Formation in the Zebrafish Neural Plate Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 523 - 534. [Abstract] [PDF]
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D.H. Rowitch, P.S. Danielian, S.M.K. Lee, Y. Echelard, and A.P. McMahon Cell Interactions in Patterning the Mammalian Midbrain Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 535 - 544. [Abstract] [PDF]
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J. Favor, R. Sandulache, A. Neuhauser-Klaus, W. Pretsch, B. Chatterjee, E. Senft, W. Wurst, V. Blanquet, P. Grimes, R. Sporle, et al. The mouse Pax21Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney PNAS, November 26, 1996; 93(24): 13870 - 13875. [Abstract] [Full Text] [PDF]
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G. C. Friedman and D. D. M. O'Leary Retroviral Misexpression of engrailed Genes in the Chick Optic Tectum Perturbs the Topographic Targeting of Retinal Axons J. Neurosci., September 1, 1996; 16(17): 5498 - 5509. [Abstract] [Full Text] [PDF]
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W Driever, L Solnica-Krezel, A. Schier, S. Neuhauss, J Malicki, D. Stemple, D. Stainier, F Zwartkruis, S Abdelilah, Z Rangini, et al. A genetic screen for mutations affecting embryogenesis in zebrafish Development, January 12, 1996; 123(1): 37 - 46. [Abstract] [PDF]
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A. Schier, S. Neuhauss, M Harvey, J Malicki, L Solnica-Krezel, D. Stainier, F Zwartkruis, S Abdelilah, D. Stemple, Z Rangini, et al. Mutations affecting the development of the embryonic zebrafish brain Development, January 12, 1996; 123(1): 165 - 178. [Abstract] [PDF]
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M Brand, C. Heisenberg, Y. Jiang, D Beuchle, K Lun, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, D. Kane, et al. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain Development, January 12, 1996; 123(1): 179 - 190. [Abstract] [PDF]
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S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts Development, January 12, 1996; 122(12): 3785 - 3797. [Abstract] [PDF]
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M Torres, E Gomez-Pardo, and P Gruss Pax2 contributes to inner ear patterning and optic nerve trajectory Development, January 11, 1996; 122(11): 3381 - 3391. [Abstract] [PDF]
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A. Davis and M. Capecchi A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse Development, January 4, 1996; 122(4): 1175 - 1185. [Abstract] [PDF]
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J Collignon, S Sockanathan, A Hacker, M Cohen-Tannoudji, D Norris, S Rastan, M Stevanovic, P. Goodfellow, and R Lovell-Badge A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2 Development, January 2, 1996; 122(2): 509 - 520. [Abstract] [PDF]
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D. Song, G Chalepakis, P Gruss, and A. Joyner Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene Development, January 2, 1996; 122(2): 627 - 635. [Abstract] [PDF]
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