|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 8 2213-2224, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
Y Echelard, G Vassileva and AP McMahon
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110.
The protooncogene Wnt-1 encodes a short-range signal which is first expressed in, and appears to demarcate, the presumptive midbrain. Absence of Wnt-1 expression leads to the loss of this region of the brain. By the end of neural tube closure, expression of Wnt-1 extends down much of the dorsal midline of the central nervous system (CNS). Expression is exclusively limited to the CNS at this and later stages. We have investigated the regulation of Wnt-1 during mouse development. Analysis of the embryonic expression of Wnt-1-lacZ reporter constructs spanning nearly 30 kb of the Wnt-1 locus identified a 5.5 kb cis-acting 3' enhancer element which confers correct temporal and spatial expression on the lacZ gene. Interestingly embryos express Wnt-1-lacZ transgenes in migrating neural crest cells which are derived from the dorsal CNS. Ectopic expression of the Wnt-1-lacZ transgenes may result from perdurance of beta-galactosidase activity in migrating neural crest cells originating from a Wnt-1-expressing region of the dorsal CNS. Alternatively, ectopic expression may arise from transient de novo activation of the transgenes in this cell population. These results are a first step towards addressing how regional cell signaling is established in the mammalian CNS. In addition, transgene expression provides a new tool for the analysis of neural crest development in normal and mutant mouse embryos.
This article has been cited by other articles:
|
|
 |
|
  S. Yamamoto, E. Fukumoto, K. Yoshizaki, T. Iwamoto, A. Yamada, K. Tanaka, H. Suzuki, S. Aizawa, M. Arakaki, K. Yuasa, et al. Platelet-derived Growth Factor Receptor Regulates Salivary Gland Morphogenesis via Fibroblast Growth Factor Expression J. Biol. Chem., August 22, 2008; 283(34): 23139 - 23149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Breau, T. Pietri, M. P. Stemmler, J. P. Thiery, and J. A. Weston A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme PNAS, June 3, 2008; 105(22): 7750 - 7755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-A. Kim, M. Wagle, K. Tran, X. Zhan, M. A. Dixon, S. Liu, D. Gros, W. Korver, S. Yonkovich, N. Tomasevic, et al. R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism Mol. Biol. Cell, June 1, 2008; 19(6): 2588 - 2596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Foster, J. Sheridan, H. Veiga-Fernandes, K. Roderick, V. Pachnis, R. Adams, C. Blackburn, D. Kioussis, and M. Coles Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus J. Immunol., March 1, 2008; 180(5): 3183 - 3189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Houten, D. H. Volle, C. L. Cummins, D. J. Mangelsdorf, and J. Auwerx In Vivo Imaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue Mol. Endocrinol., June 1, 2007; 21(6): 1312 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Andoniadou, M. Signore, E. Sajedi, C. Gaston-Massuet, D. Kelberman, A. J. Burns, N. Itasaki, M. Dattani, and J. P. Martinez-Barbera Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain Development, April 15, 2007; 134(8): 1499 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. F. Hu, Z.-J. Zhang, and M. Sieber-Blum An Epidermal Neural Crest Stem Cell (EPI-NCSC) Molecular Signature Stem Cells, December 1, 2006; 24(12): 2692 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nakamura, M. C. Colbert, and J. Robbins Neural Crest Cells Retain Multipotential Characteristics in the Developing Valves and Label the Cardiac Conduction System Circ. Res., June 23, 2006; 98(12): 1547 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kobayashi, K. M. Lyons, A. P. McMahon, and H. M. Kronenberg BMP signaling stimulates cellular differentiation at multiple steps during cartilage development PNAS, December 13, 2005; 102(50): 18023 - 18027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Evans and P. J. Gage Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development Hum. Mol. Genet., November 15, 2005; 14(22): 3347 - 3359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Singh, V. M. Christoffels, J. M. Dias, M.-O. Trowe, M. Petry, K. Schuster-Gossler, A. Burger, J. Ericson, and A. Kispert Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2 Development, June 15, 2005; 132(12): 2697 - 2707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov and K. J. Millen Control of roof plate formation by Lmx1a in the developing spinal cord Development, June 1, 2004; 131(11): 2693 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jeong, J. Mao, T. Tenzen, A. H. Kottmann, and A. P. McMahon Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia Genes & Dev., April 15, 2004; 18(8): 937 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hahm, E. Y. M. Sum, Y. Fujiwara, G. J. Lindeman, J. E. Visvader, and S. H. Orkin Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1 Mol. Cell. Biol., March 1, 2004; 24(5): 2074 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ito, J. Y. Yeo, A. Chytil, J. Han, P. Bringas Jr, A. Nakajima, C. F. Shuler, H. L. Moses, and Y. Chai Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects Development, November 1, 2003; 130(21): 5269 - 5280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bach, Y. Lallemand, M.-A. Nicola, C. Ramos, L. Mathis, M. Maufras, and B. Robert Msx1 is required for dorsal diencephalon patterning Development, September 1, 2003; 130(17): 4025 - 4036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mori-Akiyama, H. Akiyama, D. H. Rowitch, and B. de Crombrugghe Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest PNAS, August 5, 2003; 100(16): 9360 - 9365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Ligon, Y. Echelard, S. Assimacopoulos, P. S. Danielian, S. Kaing, E. A. Grove, A. P. McMahon, and D. H. Rowitch Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia Development, May 15, 2003; 130(10): 2275 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Maretto, M. Cordenonsi, S. Dupont, P. Braghetta, V. Broccoli, A. B. Hassan, D. Volpin, G. M. Bressan, and S. Piccolo Mapping Wnt/beta -catenin signaling during mouse development and in colorectal tumors PNAS, March 18, 2003; 100(6): 3299 - 3304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chai, Y. Ito, and J. Han TGF-{beta} SIGNALINGANDITS FUNCTIONAL SIGNIFICANCEIN REGULATINGTHE FATEOF CRANIAL NEURAL CREST CELLS Crit. Rev. Oral. Biol. Med., March 1, 2003; 14(2): 78 - 88. [Abstract] [Full Text]
|
|
|
|
|
|
J. Vermot, K. Niederreither, J.-M. Garnier, P. Chambon, and P. Dolle Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice PNAS, February 18, 2003; 100(4): 1763 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Tallquist and P. Soriano Cell autonomous requirement for PDGFR{alpha} in populations of cranial and cardiac neural crest cells Development, February 1, 2003; 130(3): 507 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Lagutin, C. C. Zhu, D. Kobayashi, J. Topczewski, K. Shimamura, L. Puelles, H. R.C. Russell, P. J. McKinnon, L. Solnica-Krezel, and G. Oliver Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development Genes & Dev., February 1, 2003; 17(3): 368 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nagayama, T. Katagiri, T. Tsunoda, T. Hosaka, Y. Nakashima, N. Araki, K. Kusuzaki, T. Nakayama, T. Tsuboyama, T. Nakamura, et al. Genome-wide Analysis of Gene Expression in Synovial Sarcomas Using a cDNA Microarray Cancer Res., October 15, 2002; 62(20): 5859 - 5866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. U. Frank, L. K. Fotheringham, J. A. Brewer, L. J. Muglia, M. Tristani-Firouzi, M. R. Capecchi, and A. M. Moon An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome Development, January 10, 2002; 129(19): 4591 - 4603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Anderson, G. D. Shelton, W. K. Cavenee, and K. C. Arden Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3 PNAS, February 13, 2001; 98(4): 1589 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Niederreither, J Vermot, N Messaddeq, B Schuhbaur, P Chambon, and P Dolle Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse Development, January 4, 2001; 128(7): 1019 - 1031. [Abstract] [PDF]
|
|
|
|
|
|
D. Epstein, L Martinu, J. Michaud, K. Losos, C Fan, and A. Joyner Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS Development, January 11, 2000; 127(21): 4701 - 4709. [Abstract] [PDF]
|
|
|
|
|
|
A Louvi and M Wassef Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding Development, January 9, 2000; 127(18): 4061 - 4071. [Abstract] [PDF]
|
|
|
|
|
|
O Wendling, C Dennefeld, P Chambon, and M Mark Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches Development, January 4, 2000; 127(8): 1553 - 1562. [Abstract] [PDF]
|
|
|
|
|
|
X Jiang, D. Rowitch, P Soriano, A. McMahon, and H. Sucov Fate of the mammalian cardiac neural crest Development, January 4, 2000; 127(8): 1607 - 1616. [Abstract] [PDF]
|
|
|
|
|
|
Y Chai, X Jiang, Y Ito, P Bringas, J Han, D. Rowitch, P Soriano, A. McMahon, and H. Sucov Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development, January 4, 2000; 127(8): 1671 - 1679. [Abstract] [PDF]
|
|
|
|
 |
|
 D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells J. Neurosci., October 15, 1999; 19(20): 8954 - 8965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Wong, L. Ruiz-Avila, and R. F. Margolskee Directing Gene Expression to Gustducin-Positive Taste Receptor Cells J. Neurosci., July 15, 1999; 19(14): 5802 - 5809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Gellner and S. Brenner Analysis of 148 kb of Genomic DNA Around the wnt1 Locus of Fugu rubripes Genome Res., March 1, 1999; 9(3): 251 - 258. [Abstract] [Full Text]
|
|
|
|
|
|
A Liu, K Losos, and A. Joyner FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate Development, January 11, 1999; 126(21): 4827 - 4838. [Abstract] [PDF]
|
|
|
|
|
|
D. Epstein, A. McMahon, and A. Joyner Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms Development, January 1, 1999; 126(2): 281 - 292. [Abstract] [PDF]
|
|
|
|
 |
|
 G.Y. Huang, E.S. Cooper, K. Waldo, M.L. Kirby, N.B. Gilula, and C.W. Lo Gap Junction-mediated Cell-Cell Communication Modulates Mouse Neural Crest Migration J. Cell Biol., December 14, 1998; 143(6): 1725 - 1734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Brunet, J. A. McMahon, A. P. McMahon, and R. M. Harland Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton Science, May 29, 1998; 280(5368): 1455 - 1457. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. McMahon, S. Takada, L. B. Zimmerman, C.-M. Fan, R. M. Harland, and A. P. McMahon Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite Genes & Dev., May 15, 1998; 12(10): 1438 - 1452. [Abstract] [Full Text]
|
|
|
|
|
|
M. Matise, D. Epstein, H. Park, K. Platt, and A. Joyner Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system Development, January 8, 1998; 125(15): 2759 - 2770. [Abstract] [PDF]
|
|
|
|
|
|
D. Rowitch, Y Echelard, P. Danielian, K Gellner, S Brenner, and A. McMahon Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate Development, January 7, 1998; 125(14): 2735 - 2746. [Abstract] [PDF]
|
|
|
|
|
|
A Gould, A Morrison, G Sproat, R A White, and R Krumlauf Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Genes & Dev., April 1, 1997; 11(7): 900 - 913. [Abstract] [PDF]
|
|
|
|
|
|
J. Ewart, M. Cohen, R. Meyer, G. Huang, A Wessels, R. Gourdie, A. Chin, S. Park, B. Lazatin, S Villabon, et al. Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene Development, January 4, 1997; 124(7): 1281 - 1292. [Abstract] [PDF]
|
|
|
|
|
|
S. Lee, P. Danielian, B Fritzsch, and A. McMahon Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain Development, January 3, 1997; 124(5): 959 - 969. [Abstract] [PDF]
|
|
|
|
|
|
T. Natoli, M. Ellsworth, C Wu, K. Gross, and S. Pruitt Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression Development, January 2, 1997; 124(3): 617 - 626. [Abstract] [PDF]
|
|
|
|
|
|
D. Epstein, E Marti, M. Scott, and A. McMahon Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway Development, January 9, 1996; 122(9): 2885 - 2894. [Abstract] [PDF]
|
|
|
|
|
|
K Shimamura, D. Hartigan, S Martinez, L Puelles, and J. Rubenstein Longitudinal organization of the anterior neural plate and neural tube Development, January 12, 1995; 121(12): 3923 - 3933. [Abstract] [PDF]
|
|
|
|
|
|
P. Trainor and P. Tam Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches Development, January 8, 1995; 121(8): 2569 - 2582. [Abstract] [PDF]
|
|
|
|
|
|
A. Maatta, C. Ruhrberg, and F. M. Watt Structure and Regulation of the Envoplakin Gene J. Biol. Chem., June 23, 2000; 275(26): 19857 - 19865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dono, J. Faulhaber, A. Galli, A. Zuniga, T. Volk, G. Texido, R. Zeller, and H. Ehmke FGF2 Signaling Is Required for the Development of Neuronal Circuits Regulating Blood Pressure Circ. Res., January 11, 2002; 90 (1): e5 - e10. [Abstract] [Full Text] [PDF]
|
|
