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Development, Vol 120, Issue 9 2385-2396, Copyright © 1994 by Company of Biologists


JOURNAL ARTICLES

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

R Kopan, JS Nye and H Weintraub
Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, WA 98104.

We show that Myf-5 and mNotch mRNA are both present in the presomitic mesoderm before muscle cell commitment and before muscle structural gene activation. The failure of presomitic mesoderm to respond to Myf-5 and express myogenic properties implies that there may be a mechanism in presomitic mesoderm to suppress muscle differentiation. Here we show that ectopic expression of the intracellular domain of mNotch (mNotchIC) functions as a constitutively activated repressor of myogenesis both in cultured cells and in frog embryos. Mutagenesis experiments indicate that the target for inactivation by mNotch is the MyoD basic helix-loop-helix domain. mNotchIC contains a nuclear localization signal and localizes to the nucleus. Removal of the nuclear localization signal (NLS) reduces nuclear localization and diminishes the inhibition of myogenesis caused by Myf-5 or MyoD. Additional experiments show that the CDC10/SWI6/ankyrin repeats are also necessary for myogenic inhibition.
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DevelopmentHome page
Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
Development, January 8, 1999; 126(15): 3415 - 3424.
[Abstract] [PDF]


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DevelopmentHome page
C Takke and J. Campos-Ortega
her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development
Development, January 7, 1999; 126(13): 3005 - 3014.
[Abstract] [PDF]


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DevelopmentHome page
D Nofziger, A Miyamoto, K. Lyons, and G Weinmaster
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
Development, January 4, 1999; 126(8): 1689 - 1702.
[Abstract] [PDF]


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Mol. Cell. Biol.Home page
H. K. Kim and G. Siu
The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression
Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175.
[Abstract] [Full Text]


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Mol. Cell. Biol.Home page
S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël
Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation
Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
L. T. Lam and E. H. Bresnick
Identity of the beta -Globin Locus Control Region Binding Protein HS2NF5 as the Mammalian Homolog of the Notch-regulated Transcription Factor Suppressor of Hairless
J. Biol. Chem., September 11, 1998; 273(37): 24223 - 24231.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
T. Sakai, Y. Taniguchi, K. Tamura, S. Minoguchi, T. Fukuhara, L. J. Strobl, U. Zimber-Strobl, G. W. Bornkamm, and T. Honjo
Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2
J. Virol., July 1, 1998; 72(7): 6034 - 6039.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
I. Greenwald
LIN-12/Notch signaling: lessons from worms and flies
Genes & Dev., June 15, 1998; 12(12): 1751 - 1762.
[Full Text]


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Mol. Cell. Biol.Home page
F. Oswald, S. Liptay, G. Adler, and R. M. Schmid
NF-kappa B2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jkappa
Mol. Cell. Biol., April 1, 1998; 18(4): 2077 - 2088.
[Abstract] [Full Text]


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Mol. Cell. Biol.Home page
A. Bigas, D. I. K. Martin, and L. A. Milner
Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines
Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333.
[Abstract] [Full Text]


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DevelopmentHome page
B. Harfe, C. Branda, M Krause, M. Stern, and A Fire
MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm
Development, January 7, 1998; 125(13): 2479 - 2488.
[Abstract] [PDF]


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DevelopmentHome page
J. Skeath and C. Doe
Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
Development, January 5, 1998; 125(10): 1857 - 1865.
[Abstract] [PDF]


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DevelopmentHome page
B Appel and J. Eisen
Regulation of neuronal specification in the zebrafish spinal cord by Delta function
Development, January 2, 1998; 125(3): 371 - 380.
[Abstract] [PDF]


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J. Biol. Chem.Home page
C. Garces, M. J. Ruiz-Hidalgo, J. F. de Mora, C. Park, L. Miele, J. Goldstein, E. Bonvini, A. Porras, and J. Laborda
Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis
J. Biol. Chem., November 21, 1997; 272(47): 29729 - 29734.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
J. Onions, S. Hermann, and T. Grundstrom
Basic Helix-Loop-Helix Protein Sequences Determining Differential Inhibition by Calmodulin and S-100 Proteins
J. Biol. Chem., September 19, 1997; 272(38): 23930 - 23937.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
Y. Chen, W. H. Fischer, and G. N. Gill
Regulation of the ERBB-2 Promoter by RBPJkappa and NOTCH
J. Biol. Chem., May 30, 1997; 272(22): 14110 - 14114.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar
Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jkappa or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jkappa and Activate Transcription
J. Biol. Chem., April 25, 1997; 272(17): 11336 - 11343.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
Z.-Z. Bao and C. L. Cepko
The Expression and Function of Notch Pathway Genes in the Developing Rat Eye
J. Neurosci., February 15, 1997; 17(4): 1425 - 1434.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
B. Williams and C. Ordahl
Emergence of determined myotome precursor cells in the somite
Development, January 12, 1997; 124(24): 4983 - 4997.
[Abstract] [PDF]


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DevelopmentHome page
H Kato, Y Taniguchi, H Kurooka, S Minoguchi, T Sakai, S Nomura-Okazaki, K Tamura, and T Honjo
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
Development, January 10, 1997; 124(20): 4133 - 4141.
[Abstract] [PDF]


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DevelopmentHome page
S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
Development, January 8, 1997; 124(16): 3065 - 3076.
[Abstract] [PDF]


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DevelopmentHome page
T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl
Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
Development, January 4, 1997; 124(8): 1473 - 1483.
[Abstract] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin
Inhibition of granulocytic differentiation by mNotch1
PNAS, November 12, 1996; 93(23): 13014 - 13019.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
R Eckner, T P Yao, E Oldread, and D M Livingston
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.
Genes & Dev., October 1, 1996; 10(19): 2478 - 2490.
[Abstract] [PDF]


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Genes Dev.Home page
L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.
Genes & Dev., August 1, 1996; 10(15): 1930 - 1944.
[Abstract] [PDF]


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DevelopmentHome page
H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon, and J Kitajewski
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
Development, July 1, 1996; 122(7): 2251 - 2259.
[Abstract] [PDF]


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DevelopmentHome page
A Chitnis and C Kintner
Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos
Development, July 1, 1996; 122(7): 2295 - 2301.
[Abstract] [PDF]


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DevelopmentHome page
Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al.
Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio
Development, January 12, 1996; 123(1): 205 - 216.
[Abstract] [PDF]


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DevelopmentHome page
C Shawber, D Nofziger, J. Hsieh, C Lindsell, O Bogler, D Hayward, and G Weinmaster
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
Development, January 12, 1996; 122(12): 3765 - 3773.
[Abstract] [PDF]


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DevelopmentHome page
G Daston, E Lamar, M Olivier, and M Goulding
Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
Development, January 3, 1996; 122(3): 1017 - 1027.
[Abstract] [PDF]




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