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Development, Vol 120, Issue 9 2385-2396, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
R Kopan, JS Nye and H Weintraub
Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, WA 98104.
We show that Myf-5 and mNotch mRNA are both present in the presomitic mesoderm before muscle cell commitment and before muscle structural gene activation. The failure of presomitic mesoderm to respond to Myf-5 and express myogenic properties implies that there may be a mechanism in presomitic mesoderm to suppress muscle differentiation. Here we show that ectopic expression of the intracellular domain of mNotch (mNotchIC) functions as a constitutively activated repressor of myogenesis both in cultured cells and in frog embryos. Mutagenesis experiments indicate that the target for inactivation by mNotch is the MyoD basic helix-loop-helix domain. mNotchIC contains a nuclear localization signal and localizes to the nucleus. Removal of the nuclear localization signal (NLS) reduces nuclear localization and diminishes the inhibition of myogenesis caused by Myf-5 or MyoD. Additional experiments show that the CDC10/SWI6/ankyrin repeats are also necessary for myogenic inhibition.
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J. Zhang, H. Chen, G. Weinmaster, and S. D. Hayward Epstein-Barr Virus BamHI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC J. Virol., March 15, 2001; 75(6): 2946 - 2956. [Abstract] [Full Text]
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 S. Tani, H. Kurooka, T. Aoki, N. Hashimoto, and T. Honjo The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription Nucleic Acids Res., March 15, 2001; 29(6): 1373 - 1380. [Abstract] [Full Text] [PDF]
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J. C. Aster, L. Xu, F. G. Karnell, V. Patriub, J. C. Pui, and W. S. Pear Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1 Mol. Cell. Biol., October 15, 2000; 20(20): 7505 - 7515. [Abstract] [Full Text]
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K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]
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B. J. Feldman, T. Hampton, and M. L. Cleary A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice Blood, September 1, 2000; 96(5): 1906 - 1913. [Abstract] [Full Text] [PDF]
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S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF]
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S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]
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J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C Mol. Cell. Biol., April 1, 1999; 19(4): 2853 - 2862. [Abstract] [Full Text] [PDF]
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K. Kuroda, S. Tani, K. Tamura, S. Minoguchi, H. Kurooka, and T. Honjo Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis J. Biol. Chem., March 12, 1999; 274(11): 7238 - 7244. [Abstract] [Full Text] [PDF]
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Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF]
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C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
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D Nofziger, A Miyamoto, K. Lyons, and G Weinmaster Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts Development, January 4, 1999; 126(8): 1689 - 1702. [Abstract] [PDF]
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H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text]
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S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text]
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L. T. Lam and E. H. Bresnick Identity of the beta -Globin Locus Control Region Binding Protein HS2NF5 as the Mammalian Homolog of the Notch-regulated Transcription Factor Suppressor of Hairless J. Biol. Chem., September 11, 1998; 273(37): 24223 - 24231. [Abstract] [Full Text] [PDF]
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T. Sakai, Y. Taniguchi, K. Tamura, S. Minoguchi, T. Fukuhara, L. J. Strobl, U. Zimber-Strobl, G. W. Bornkamm, and T. Honjo Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2 J. Virol., July 1, 1998; 72(7): 6034 - 6039. [Abstract] [Full Text] [PDF]
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I. Greenwald LIN-12/Notch signaling: lessons from worms and flies Genes & Dev., June 15, 1998; 12(12): 1751 - 1762. [Full Text]
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F. Oswald, S. Liptay, G. Adler, and R. M. Schmid NF-kappa B2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jkappa Mol. Cell. Biol., April 1, 1998; 18(4): 2077 - 2088. [Abstract] [Full Text]
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A. Bigas, D. I. K. Martin, and L. A. Milner Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333. [Abstract] [Full Text]
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B. Harfe, C. Branda, M Krause, M. Stern, and A Fire MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm Development, January 7, 1998; 125(13): 2479 - 2488. [Abstract] [PDF]
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J. Skeath and C. Doe Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS Development, January 5, 1998; 125(10): 1857 - 1865. [Abstract] [PDF]
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B Appel and J. Eisen Regulation of neuronal specification in the zebrafish spinal cord by Delta function Development, January 2, 1998; 125(3): 371 - 380. [Abstract] [PDF]
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C. Garces, M. J. Ruiz-Hidalgo, J. F. de Mora, C. Park, L. Miele, J. Goldstein, E. Bonvini, A. Porras, and J. Laborda Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis J. Biol. Chem., November 21, 1997; 272(47): 29729 - 29734. [Abstract] [Full Text] [PDF]
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J. Onions, S. Hermann, and T. Grundstrom Basic Helix-Loop-Helix Protein Sequences Determining Differential Inhibition by Calmodulin and S-100 Proteins J. Biol. Chem., September 19, 1997; 272(38): 23930 - 23937. [Abstract] [Full Text] [PDF]
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Y. Chen, W. H. Fischer, and G. N. Gill Regulation of the ERBB-2 Promoter by RBPJkappa and NOTCH J. Biol. Chem., May 30, 1997; 272(22): 14110 - 14114. [Abstract] [Full Text] [PDF]
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J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jkappa or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jkappa and Activate Transcription J. Biol. Chem., April 25, 1997; 272(17): 11336 - 11343. [Abstract] [Full Text] [PDF]
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 Z.-Z. Bao and C. L. Cepko The Expression and Function of Notch Pathway Genes in the Developing Rat Eye J. Neurosci., February 15, 1997; 17(4): 1425 - 1434. [Abstract] [Full Text] [PDF]
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B. Williams and C. Ordahl Emergence of determined myotome precursor cells in the somite Development, January 12, 1997; 124(24): 4983 - 4997. [Abstract] [PDF]
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H Kato, Y Taniguchi, H Kurooka, S Minoguchi, T Sakai, S Nomura-Okazaki, K Tamura, and T Honjo Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives Development, January 10, 1997; 124(20): 4133 - 4141. [Abstract] [PDF]
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S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Development, January 8, 1997; 124(16): 3065 - 3076. [Abstract] [PDF]
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T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4 Development, January 4, 1997; 124(8): 1473 - 1483. [Abstract] [PDF]
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L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin Inhibition of granulocytic differentiation by mNotch1 PNAS, November 12, 1996; 93(23): 13014 - 13019. [Abstract] [Full Text] [PDF]
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R Eckner, T P Yao, E Oldread, and D M Livingston Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes & Dev., October 1, 1996; 10(19): 2478 - 2490. [Abstract] [PDF]
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L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes & Dev., August 1, 1996; 10(15): 1930 - 1944. [Abstract] [PDF]
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H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon, and J Kitajewski Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene Development, July 1, 1996; 122(7): 2251 - 2259. [Abstract] [PDF]
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A Chitnis and C Kintner Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos Development, July 1, 1996; 122(7): 2295 - 2301. [Abstract] [PDF]
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Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 205 - 216. [Abstract] [PDF]
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C Shawber, D Nofziger, J. Hsieh, C Lindsell, O Bogler, D Hayward, and G Weinmaster Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway Development, January 12, 1996; 122(12): 3765 - 3773. [Abstract] [PDF]
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G Daston, E Lamar, M Olivier, and M Goulding Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse Development, January 3, 1996; 122(3): 1017 - 1027. [Abstract] [PDF]
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