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Development, Vol 120, Issue 9 2385-2396, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
R Kopan, JS Nye and H Weintraub
Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, WA 98104.
We show that Myf-5 and mNotch mRNA are both present in the presomitic mesoderm before muscle cell commitment and before muscle structural gene activation. The failure of presomitic mesoderm to respond to Myf-5 and express myogenic properties implies that there may be a mechanism in presomitic mesoderm to suppress muscle differentiation. Here we show that ectopic expression of the intracellular domain of mNotch (mNotchIC) functions as a constitutively activated repressor of myogenesis both in cultured cells and in frog embryos. Mutagenesis experiments indicate that the target for inactivation by mNotch is the MyoD basic helix-loop-helix domain. mNotchIC contains a nuclear localization signal and localizes to the nucleus. Removal of the nuclear localization signal (NLS) reduces nuclear localization and diminishes the inhibition of myogenesis caused by Myf-5 or MyoD. Additional experiments show that the CDC10/SWI6/ankyrin repeats are also necessary for myogenic inhibition.
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F. Oswald, B. Tauber, T. Dobner, S. Bourteele, U. Kostezka, G. Adler, S. Liptay, and R. M. Schmid p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1 Mol. Cell. Biol., November 15, 2001; 21(22): 7761 - 7774. [Abstract] [Full Text] [PDF]
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S. Zhou and S. D. Hayward Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex Mol. Cell. Biol., September 15, 2001; 21(18): 6222 - 6232. [Abstract] [Full Text] [PDF]
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E. Lamar, G. Deblandre, D. Wettstein, V. Gawantka, N. Pollet, C. Niehrs, and C. Kintner Nrarp is a novel intracellular component of the Notch signaling pathway Genes & Dev., August 1, 2001; 15(15): 1885 - 1899. [Abstract] [Full Text] [PDF]
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 A. V. Gordadze, R. Peng, J. Tan, G. Liu, R. Sutton, B. Kempkes, G. W. Bornkamm, and P. D. Ling Notch1IC Partially Replaces EBNA2 Function in B Cells Immortalized by Epstein-Barr Virus J. Virol., July 1, 2001; 75(13): 5899 - 5912. [Abstract] [Full Text] [PDF]
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B. K. Hadland, N. R. Manley, D.-m. Su, G. D. Longmore, C. L. Moore, M. S. Wolfe, E. H. Schroeter, and R. Kopan gamma -Secretase inhibitors repress thymocyte development PNAS, June 19, 2001; 98(13): 7487 - 7491. [Abstract] [Full Text] [PDF]
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J. Zhang, H. Chen, G. Weinmaster, and S. D. Hayward Epstein-Barr Virus BamHI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC J. Virol., March 15, 2001; 75(6): 2946 - 2956. [Abstract] [Full Text]
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 S. Tani, H. Kurooka, T. Aoki, N. Hashimoto, and T. Honjo The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription Nucleic Acids Res., March 15, 2001; 29(6): 1373 - 1380. [Abstract] [Full Text] [PDF]
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E Hirsinger, P Malapert, J Dubrulle, M. Delfini, D Duprez, D Henrique, D Ish-Horowicz, and O Pourquie Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation Development, January 1, 2001; 128(1): 107 - 116. [Abstract] [PDF]
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J. C. Aster, L. Xu, F. G. Karnell, V. Patriub, J. C. Pui, and W. S. Pear Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1 Mol. Cell. Biol., October 15, 2000; 20(20): 7505 - 7515. [Abstract] [Full Text]
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 H. T. Tan-Pertel, L. Walker, D. Browning, A. Miyamoto, G. Weinmaster, and J. C. Gasson Notch Signaling Enhances Survival and Alters Differentiation of 32D Myeloblasts J. Immunol., October 15, 2000; 165(8): 4428 - 4436. [Abstract] [Full Text] [PDF]
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K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]
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B. J. Feldman, T. Hampton, and M. L. Cleary A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice Blood, September 1, 2000; 96(5): 1906 - 1913. [Abstract] [Full Text] [PDF]
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S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF]
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S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]
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K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Blood, May 1, 2000; 95(9): 2847 - 2854. [Abstract] [Full Text] [PDF]
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S. Zhou, M. Fujimuro, J. J.-D. Hsieh, L. Chen, A. Miyamoto, G. Weinmaster, and S. D. Hayward SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function Mol. Cell. Biol., April 1, 2000; 20(7): 2400 - 2410. [Abstract] [Full Text]
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L. J. Strobl, H. Höfelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2 J. Virol., February 15, 2000; 74(4): 1727 - 1735. [Abstract] [Full Text]
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B Varnum-Finney, L Wu, M Yu, C Brashem-Stein, S Staats, D Flowers, J. Griffin, and I. Bernstein Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling J. Cell Sci., January 12, 2000; 113(23): 4313 - 4318. [Abstract] [PDF]
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M Delfini, E Hirsinger, O Pourquie, and D Duprez Delta 1-activated notch inhibits muscle differentiation without affecting Myf5 and Pax3 expression in chick limb myogenesis Development, January 12, 2000; 127(23): 5213 - 5224. [Abstract] [PDF]
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W. J. Ray, M. Yao, J. Mumm, E. H. Schroeter, P. Saftig, M. Wolfe, D. J. Selkoe, R. Kopan, and A. M. Goate Cell Surface Presenilin-1 Participates in the gamma -Secretase-like Proteolysis of Notch J. Biol. Chem., December 17, 1999; 274(51): 36801 - 36807. [Abstract] [Full Text] [PDF]
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