|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 9 2567-2578, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
A Prokop and GM Technau
Institut fur Genetik-Zellbiologie, Mainz, Germany.
The developing central nervous system of many species expresses distinct segment-specific characteristics. We recently described the entire embryonic lineage of Drosophila neuroblast NB1-1 and showed that the composition of this lineage differs between the thoracic and abdominal tagmata with respect to the presence or absence of specific glial and neuronal components (Udolph, G., Prokop, A., Bossing, T. and Technau, G. M. (1993) Development 118, 765-775). Here, we demonstrate by heterotopic transplantations that tagma specificity of NB1-1 is determined in the neuroectoderm at the early gastrula stage (stage 7). Heterogenetic transplantation and mutant analysis show that the activity of the homeotic genes Ubx or abd-A is required for the expression of the abdominal variant of the lineage. Heat induction of Ubx or abd-A expression or their derepression in Polycomb mutant embryos can override thoracic determination several hours after gastrulation (stage 10/11). At that stage antibody stainings reveal both proteins to be present in NB1-1 during normal development. Possible mechanisms conferring the early tagma-specific determination are discussed.
This article has been cited by other articles:
|
|
 |
|
  B. Bello, N. Holbro, and H. Reichert Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila Development, March 15, 2007; 134(6): 1091 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rogulja-Ortmann, K. Luer, J. Seibert, C. Rickert, and G. M. Technau Programmed cell death in the embryonic central nervous system of Drosophila melanogaster Development, January 1, 2007; 134(1): 105 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Grosskortenhaus, K. J. Robinson, and C. Q. Doe Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage Genes & Dev., September 15, 2006; 20(18): 2618 - 2627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Miguel-Aliaga and S. Thor Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity Development, December 15, 2004; 131(24): 6093 - 6105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Urbach and G. M. Technau Molecular markers for identified neuroblasts in the developing brain of Drosophila Development, August 15, 2003; 130(16): 3621 - 3637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Brody and W. F. Odenwald Cellular diversity in the developing nervous system: a temporal view from Drosophila Development, March 10, 2003; 129(16): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Udolph, P Rath, and W Chia A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions Development, January 4, 2001; 128(8): 1457 - 1466. [Abstract] [PDF]
|
|
|
|
|
|
Y Akiyama-Oda, T Hosoya, and Y Hotta Asymmetric cell division of thoracic neuroblast 6-4 to bifurcate glial and neuronal lineage in Drosophila Development, January 5, 1999; 126(9): 1967 - 1974. [Abstract] [PDF]
|
|
|
|
|
|
G Udolph, J Urban, G Rusing, K Luer, and G. Technau Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS Development, January 9, 1998; 125(17): 3291 - 3299. [Abstract] [PDF]
|
|
|
|
|
|
X Yang, S Bahri, T Klein, and W Chia Klumpfuss, a putative Drosophila zinc finger transcription factor, acts to differentiate between the identities of two secondary precursor cells within one neuroblast lineage. Genes & Dev., June 1, 1997; 11(11): 1396 - 1408. [Abstract] [PDF]
|
|
|
|
|
|
K. Bhat and P Schedl Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis Development, January 5, 1997; 124(9): 1675 - 1688. [Abstract] [PDF]
|
|
|
|
 |
|
 G Udolph, K Luer, T Bossing, and G. Technau Commitment of CNS progenitors along the dorsoventral axis of Drosophila neuroectoderm Science, September 1, 1995; 269(5228): 1278 - 1281. [Abstract] [PDF]
|
|
|
|
|
|
S L Yeo, A Lloyd, K Kozak, A Dinh, T Dick, X Yang, S Sakonju, and W Chia On the functional overlap between two Drosophila POU homeo domain genes and the cell fate specification of a CNS neural precursor. Genes & Dev., May 15, 1995; 9(10): 1223 - 1236. [Abstract] [PDF]
|
|
|
|
|
|
K Weigmann and C. Lehner Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression Development, January 11, 1995; 121(11): 3713 - 3721. [Abstract] [PDF]
|
|
