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Development, Vol 121, Issue 1 11-18, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
Y Guz, MR Montminy, R Stein, J Leonard, LW Gamer, CV Wright and G Teitelman
Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn 11203.
The XlHbox 8 homeodomain protein of Xenopus and STF-1, its mammalian homolog, are selectively expressed by beta cells of adult mouse pancreatic islets, where they are likely to regulate insulin expression. We sought to determine whether the expression of the homeobox protein/s during mouse embryonic development was specific to beta cells or, alternatively, whether XlHbox 8/STF-1 protein/s were initially expressed by multipotential precursors and only later became restricted to the insulin-containing cells. With two antibodies, we studied the localization of STF-1 during murine pancreatic development. In embryos, as in adults, STF-1 was expressed by most beta cells, by subsets of the other islet cell types and by mucosal epithelial cells of the duodenum. In addition, most epithelial cells of the pancreatic duct and exocrine cells of the pancreas transiently contained STF-1. We conclude that in mouse, STF-1 not only labels a domain of intestinal epithelial cells but also provides a spatial and temporal marker of endodermal commitment to a pancreatic and subsequently, to an endocrine beta cell fate. We propose a model of pancreatic cell development that suggests that exocrine and endocrine (alpha, beta, delta and PP) cells arise from a common precursor pool of STF-1+ cells and that progression towards a defined monospecific non-beta cell type is correlated with loss of STF-1 expression.
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|
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|
|
|
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|
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|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
|
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|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
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|
|
|
|
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|
|
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|
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|
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|
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|
|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
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|
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|
|
|
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M. Peshavaria, M. A. Cissell, E. Henderson, H. V. Petersen, and R. Stein The PDX-1 Activation Domain Provides Specific Functions Necessary for Transcriptional Stimulation in Pancreatic {beta}-Cells Mol. Endocrinol., December 1, 2000; 14(12): 1907 - 1917. [Abstract] [Full Text]
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S. Marshak, E. Benshushan, M. Shoshkes, L. Havin, E. Cerasi, and D. Melloul Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3beta Transcription Factors Mediate beta -Cell-Specific Expression Mol. Cell. Biol., October 15, 2000; 20(20): 7583 - 7590. [Abstract] [Full Text]
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S. Bonner-Weir, M. Taneja, G. C. Weir, K. Tatarkiewicz, K.-H. Song, A. Sharma, and J. J. O'Neil In vitro cultivation of human islets from expanded ductal tissue PNAS, July 5, 2000; 97(14): 7999 - 8004. [Abstract] [Full Text] [PDF]
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K. Gerrish, M. Gannon, D. Shih, E. Henderson, M. Stoffel, C. V. E. Wright, and R. Stein Pancreatic beta Cell-specific Transcription of the pdx-1 Gene. THE ROLE OF CONSERVED UPSTREAM CONTROL REGIONS AND THEIR HEPATIC NUCLEAR FACTOR 3beta SITES J. Biol. Chem., February 4, 2000; 275(5): 3485 - 3492. [Abstract] [Full Text] [PDF]
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V. Schwitzgebel, D. Scheel, J. Conners, J Kalamaras, J. Lee, D. Anderson, L Sussel, J. Johnson, and M. German Expression of neurogenin3 reveals an islet cell precursor population in the pancreas Development, January 8, 2000; 127(16): 3533 - 3542. [Abstract] [PDF]
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P. Herrera Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages Development, January 6, 2000; 127(11): 2317 - 2322. [Abstract] [PDF]
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D. A. Stoffers, R. S. Heller, C. P. Miller, and J. F. Habener Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter Endocrinology, November 1, 1999; 140(11): 5374 - 5381. [Abstract] [Full Text]
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R. Seijffers, O. Ben-David, Y. Cohen, A. Karasik, M. Berezin, C. B. Newgard, and S. Ferber Increase in PDX-1 Levels Suppresses Insulin Gene Expression in RIN 1046-38 Cells Endocrinology, July 1, 1999; 140(7): 3311 - 3317. [Abstract] [Full Text]
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 J. Jung, M. Zheng, M. Goldfarb, and K. S. Zaret Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors Science, June 18, 1999; 284(5422): 1998 - 2003. [Abstract] [Full Text]
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S. Beimesche, A. Neubauer, S. Herzig, R. Grzeskowiak, T. Diedrich, I. Cierny, D. Scholz, T. Alejel, and W. Knepel Tissue-Specific Transcriptional Activity of a Pancreatic Islet Cell-Specific Enhancer Sequence/Pax6-Binding Site Determined in Normal Adult Tissues in Vivo Using Transgenic Mice Mol. Endocrinol., May 1, 1999; 13(5): 718 - 728. [Abstract] [Full Text]
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W. M. Macfarlane, C. M. McKinnon, Z. A. Felton-Edkins, H. Cragg, R. F. L. James, and K. Docherty Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic beta -Cells J. Biol. Chem., January 8, 1999; 274(2): 1011 - 1016. [Abstract] [Full Text] [PDF]
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T. L. Jetton, J. M. Moates, J. Lindner, C. V. E. Wright, and M. A. Magnuson Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells PNAS, July 21, 1998; 95(15): 8654 - 8659. [Abstract] [Full Text] [PDF]
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U. Ahlgren, J. Jonsson, L. Jonsson, K. Simu, and H. Edlund beta -Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta -cell phenotype and maturity onset diabetes Genes & Dev., June 15, 1998; 12(12): 1763 - 1768. [Abstract] [Full Text]
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A. Øster, J. Jensen, P. Serup, P. Galante, O. D. Madsen, and L.-I. Larsson Rat Endocrine Pancreatic Development in Relation to Two Homeobox Gene Products (Pdx-1 and Nkx 6.1) J. Histochem. Cytochem., June 1, 1998; 46(6): 707 - 716. [Abstract] [Full Text]
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Y. Qiu, A. Sharma, and R. Stein p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene Mol. Cell. Biol., May 1, 1998; 18(5): 2957 - 2964. [Abstract] [Full Text]
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W. M. Milewski, S. J. Duguay, S. J. Chan, and D. F. Steiner Conservation of PDX-1 Structure, Function, and Expression in Zebrafish Endocrinology, March 1, 1998; 139(3): 1440 - 1449. [Abstract] [Full Text] [PDF]
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L. K. Olson, J. Qian, and V. Poitout Glucose Rapidly and Reversibly Decreases INS-1 Cell Insulin Gene Transcription via Decrements in STF-1 and C1 Activator Transcription Factor Activity Mol. Endocrinol., February 1, 1998; 12(2): 207 - 219. [Abstract] [Full Text]
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L Sussel, J Kalamaras, D. Hartigan-O'Connor, J. Meneses, R. Pedersen, J. Rubenstein, and M. German Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells Development, January 6, 1998; 125(12): 2213 - 2221. [Abstract] [PDF]
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H. Kaneto, J.-i. Miyagawa, Y. Kajimoto, K. Yamamoto, H. Watada, Y. Umayahara, T. Hanafusa, Y. Matsuzawa, Y. Yamasaki, S. Higashiyama, et al. Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development. A POTENTIAL ROLE OF PDX-1 IN TRANSCRIPTIONAL ACTIVATION J. Biol. Chem., November 14, 1997; 272(46): 29137 - 29143. [Abstract] [Full Text] [PDF]
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M. Jackerott and L.-I. Larsson Immunocytochemical Localization of the NPY/PYY Y1 Receptor in the Developing Pancreas Endocrinology, November 1, 1997; 138(11): 5013 - 5018. [Abstract] [Full Text] [PDF]
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A. Sharma, E. Henderson, L. Gamer, Y. Zhuang, and R. Stein Analysis of the Role of E2A-Encoded Proteins in Insulin Gene Transcription Mol. Endocrinol., October 1, 1997; 11(11): 1608 - 1617. [Abstract] [Full Text]
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F. J. Naya, H.-P. Huang, Y. Qiu, H. Mutoh, F. J. DeMayo, A. B. Leiter, and M.-J. Tsai Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice Genes & Dev., September 15, 1997; 11(18): 2323 - 2334. [Abstract] [Full Text] [PDF]
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K.-M. Yao, M. Sha, Z. Lu, and G. G. Wong Molecular Analysis of a Novel Winged Helix Protein, WIN. EXPRESSION PATTERN, DNA BINDING PROPERTY, AND ALTERNATIVE SPLICING WITHIN THE DNA BINDING DOMAIN J. Biol. Chem., August 8, 1997; 272(32): 19827 - 19836. [Abstract] [Full Text] [PDF]
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M Sander, A Neubuser, J Kalamaras, H C Ee, G R Martin, and M S German Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes & Dev., July 1, 1997; 11(13): 1662 - 1673. [Abstract] [PDF]
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B. Duvillie, N. Cordonnier, L. Deltour, F. Dandoy-Dron, J.-M. Itier, E. Monthioux, J. Jami, R. L. Joshi, and D. Bucchini Phenotypic alterations in insulin-deficient mutant mice PNAS, May 13, 1997; 94(10): 5137 - 5140. [Abstract] [Full Text] [PDF]
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S. Marshak, H. Totary, E. Cerasi, and D. Melloul Purification of the beta -cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells PNAS, December 24, 1996; 93(26): 15057 - 15062. [Abstract] [Full Text] [PDF]
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M. Knofler, A. Krapp, O. Hagenbuchle, and P. K. Wellauer Constitutive Expression of the Gene for the Cell-specific p48 DNA-binding Subunit of Pancreas Transcription Factor 1in Cultured Cells Is under Control of Binding Sites for Transcription Factors Sp1 and alpha Cbf J. Biol. Chem., September 6, 1996; 271(36): 21993 - 22002. [Abstract] [Full Text] [PDF]
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