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Development, Vol 121, Issue 1 11-18, Copyright © 1995 by Company of Biologists


JOURNAL ARTICLES

Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

Y Guz, MR Montminy, R Stein, J Leonard, LW Gamer, CV Wright and G Teitelman
Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn 11203.

The XlHbox 8 homeodomain protein of Xenopus and STF-1, its mammalian homolog, are selectively expressed by beta cells of adult mouse pancreatic islets, where they are likely to regulate insulin expression. We sought to determine whether the expression of the homeobox protein/s during mouse embryonic development was specific to beta cells or, alternatively, whether XlHbox 8/STF-1 protein/s were initially expressed by multipotential precursors and only later became restricted to the insulin-containing cells. With two antibodies, we studied the localization of STF-1 during murine pancreatic development. In embryos, as in adults, STF-1 was expressed by most beta cells, by subsets of the other islet cell types and by mucosal epithelial cells of the duodenum. In addition, most epithelial cells of the pancreatic duct and exocrine cells of the pancreas transiently contained STF-1. We conclude that in mouse, STF-1 not only labels a domain of intestinal epithelial cells but also provides a spatial and temporal marker of endodermal commitment to a pancreatic and subsequently, to an endocrine beta cell fate. We propose a model of pancreatic cell development that suggests that exocrine and endocrine (alpha, beta, delta and PP) cells arise from a common precursor pool of STF-1+ cells and that progression towards a defined monospecific non-beta cell type is correlated with loss of STF-1 expression.
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A. Bhushan, N. Itoh, S. Kato, J. P. Thiery, P. Czernichow, S. Bellusci, and R. Scharfmann
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
Development, December 15, 2001; 128(24): 5109 - 5117.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. Gerrish, M. A. Cissell, and R. Stein
The Role of Hepatic Nuclear Factor 1alpha and PDX-1 in Transcriptional Regulation of the pdx-1 Gene
J. Biol. Chem., December 14, 2001; 276(51): 47775 - 47784.
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Genes Dev.Home page
Z. Sun and N. Hopkins
vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain
Genes & Dev., December 1, 2001; 15(23): 3217 - 3229.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
J. M. Rossi, N. R. Dunn, B. L.M. Hogan, and K. S. Zaret
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
Genes & Dev., August 1, 2001; 15(15): 1998 - 2009.
[Abstract] [Full Text] [PDF]


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J. Histochem. Cytochem.Home page
C. Roberts, G. A. Roberts, K. Löbner, M. Bearzatto, A. Clark, E. Bonifacio, and M. R. Christie
Expression of the Protein Tyrosine Phosphatase-like Protein IA-2 During Pancreatic Islet Development
J. Histochem. Cytochem., June 1, 2001; 49(6): 767 - 776.
[Abstract] [Full Text]


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DevelopmentHome page
G Deutsch, J Jung, M Zheng, J Lora, and K. Zaret
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Development, January 3, 2001; 128(6): 871 - 881.
[Abstract] [PDF]


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Mol. Endocrinol.Home page
M. Peshavaria, M. A. Cissell, E. Henderson, H. V. Petersen, and R. Stein
The PDX-1 Activation Domain Provides Specific Functions Necessary for Transcriptional Stimulation in Pancreatic {beta}-Cells
Mol. Endocrinol., December 1, 2000; 14(12): 1907 - 1917.
[Abstract] [Full Text]


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Mol. Cell. Biol.Home page
S. Marshak, E. Benshushan, M. Shoshkes, L. Havin, E. Cerasi, and D. Melloul
Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3beta Transcription Factors Mediate beta -Cell-Specific Expression
Mol. Cell. Biol., October 15, 2000; 20(20): 7583 - 7590.
[Abstract] [Full Text]


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Proc. Natl. Acad. Sci. USAHome page
S. Bonner-Weir, M. Taneja, G. C. Weir, K. Tatarkiewicz, K.-H. Song, A. Sharma, and J. J. O'Neil
In vitro cultivation of human islets from expanded ductal tissue
PNAS, July 5, 2000; 97(14): 7999 - 8004.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. Gerrish, M. Gannon, D. Shih, E. Henderson, M. Stoffel, C. V. E. Wright, and R. Stein
Pancreatic beta Cell-specific Transcription of the pdx-1 Gene. THE ROLE OF CONSERVED UPSTREAM CONTROL REGIONS AND THEIR HEPATIC NUCLEAR FACTOR 3beta SITES
J. Biol. Chem., February 4, 2000; 275(5): 3485 - 3492.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
V. Schwitzgebel, D. Scheel, J. Conners, J Kalamaras, J. Lee, D. Anderson, L Sussel, J. Johnson, and M. German
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
Development, January 8, 2000; 127(16): 3533 - 3542.
[Abstract] [PDF]


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DevelopmentHome page
P. Herrera
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
Development, January 6, 2000; 127(11): 2317 - 2322.
[Abstract] [PDF]


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EndocrinologyHome page
D. A. Stoffers, R. S. Heller, C. P. Miller, and J. F. Habener
Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter
Endocrinology, November 1, 1999; 140(11): 5374 - 5381.
[Abstract] [Full Text]


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EndocrinologyHome page
R. Seijffers, O. Ben-David, Y. Cohen, A. Karasik, M. Berezin, C. B. Newgard, and S. Ferber
Increase in PDX-1 Levels Suppresses Insulin Gene Expression in RIN 1046-38 Cells
Endocrinology, July 1, 1999; 140(7): 3311 - 3317.
[Abstract] [Full Text]


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ScienceHome page
J. Jung, M. Zheng, M. Goldfarb, and K. S. Zaret
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Science, June 18, 1999; 284(5422): 1998 - 2003.
[Abstract] [Full Text]


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Mol. Endocrinol.Home page
S. Beimesche, A. Neubauer, S. Herzig, R. Grzeskowiak, T. Diedrich, I. Cierny, D. Scholz, T. Alejel, and W. Knepel
Tissue-Specific Transcriptional Activity of a Pancreatic Islet Cell-Specific Enhancer Sequence/Pax6-Binding Site Determined in Normal Adult Tissues in Vivo Using Transgenic Mice
Mol. Endocrinol., May 1, 1999; 13(5): 718 - 728.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
W. M. Macfarlane, C. M. McKinnon, Z. A. Felton-Edkins, H. Cragg, R. F. L. James, and K. Docherty
Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic beta -Cells
J. Biol. Chem., January 8, 1999; 274(2): 1011 - 1016.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
T. L. Jetton, J. M. Moates, J. Lindner, C. V. E. Wright, and M. A. Magnuson
Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells
PNAS, July 21, 1998; 95(15): 8654 - 8659.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
U. Ahlgren, J. Jonsson, L. Jonsson, K. Simu, and H. Edlund
beta -Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta -cell phenotype and maturity onset diabetes
Genes & Dev., June 15, 1998; 12(12): 1763 - 1768.
[Abstract] [Full Text]


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J. Histochem. Cytochem.Home page
A. Øster, J. Jensen, P. Serup, P. Galante, O. D. Madsen, and L.-I. Larsson
Rat Endocrine Pancreatic Development in Relation to Two Homeobox Gene Products (Pdx-1 and Nkx 6.1)
J. Histochem. Cytochem., June 1, 1998; 46(6): 707 - 716.
[Abstract] [Full Text]


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Mol. Cell. Biol.Home page
Y. Qiu, A. Sharma, and R. Stein
p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene
Mol. Cell. Biol., May 1, 1998; 18(5): 2957 - 2964.
[Abstract] [Full Text]


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EndocrinologyHome page
W. M. Milewski, S. J. Duguay, S. J. Chan, and D. F. Steiner
Conservation of PDX-1 Structure, Function, and Expression in Zebrafish
Endocrinology, March 1, 1998; 139(3): 1440 - 1449.
[Abstract] [Full Text] [PDF]


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Mol. Endocrinol.Home page
L. K. Olson, J. Qian, and V. Poitout
Glucose Rapidly and Reversibly Decreases INS-1 Cell Insulin Gene Transcription via Decrements in STF-1 and C1 Activator Transcription Factor Activity
Mol. Endocrinol., February 1, 1998; 12(2): 207 - 219.
[Abstract] [Full Text]


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DevelopmentHome page
L Sussel, J Kalamaras, D. Hartigan-O'Connor, J. Meneses, R. Pedersen, J. Rubenstein, and M. German
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
Development, January 6, 1998; 125(12): 2213 - 2221.
[Abstract] [PDF]


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J. Biol. Chem.Home page
H. Kaneto, J.-i. Miyagawa, Y. Kajimoto, K. Yamamoto, H. Watada, Y. Umayahara, T. Hanafusa, Y. Matsuzawa, Y. Yamasaki, S. Higashiyama, et al.
Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development. A POTENTIAL ROLE OF PDX-1 IN TRANSCRIPTIONAL ACTIVATION
J. Biol. Chem., November 14, 1997; 272(46): 29137 - 29143.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
M. Jackerott and L.-I. Larsson
Immunocytochemical Localization of the NPY/PYY Y1 Receptor in the Developing Pancreas
Endocrinology, November 1, 1997; 138(11): 5013 - 5018.
[Abstract] [Full Text] [PDF]


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Mol. Endocrinol.Home page
A. Sharma, E. Henderson, L. Gamer, Y. Zhuang, and R. Stein
Analysis of the Role of E2A-Encoded Proteins in Insulin Gene Transcription
Mol. Endocrinol., October 1, 1997; 11(11): 1608 - 1617.
[Abstract] [Full Text]


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Genes Dev.Home page
F. J. Naya, H.-P. Huang, Y. Qiu, H. Mutoh, F. J. DeMayo, A. B. Leiter, and M.-J. Tsai
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
Genes & Dev., September 15, 1997; 11(18): 2323 - 2334.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K.-M. Yao, M. Sha, Z. Lu, and G. G. Wong
Molecular Analysis of a Novel Winged Helix Protein, WIN. EXPRESSION PATTERN, DNA BINDING PROPERTY, AND ALTERNATIVE SPLICING WITHIN THE DNA BINDING DOMAIN
J. Biol. Chem., August 8, 1997; 272(32): 19827 - 19836.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
M Sander, A Neubuser, J Kalamaras, H C Ee, G R Martin, and M S German
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
Genes & Dev., July 1, 1997; 11(13): 1662 - 1673.
[Abstract] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
B. Duvillie, N. Cordonnier, L. Deltour, F. Dandoy-Dron, J.-M. Itier, E. Monthioux, J. Jami, R. L. Joshi, and D. Bucchini
Phenotypic alterations in insulin-deficient mutant mice
PNAS, May 13, 1997; 94(10): 5137 - 5140.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
S. Marshak, H. Totary, E. Cerasi, and D. Melloul
Purification of the beta -cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
PNAS, December 24, 1996; 93(26): 15057 - 15062.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. Knofler, A. Krapp, O. Hagenbuchle, and P. K. Wellauer
Constitutive Expression of the Gene for the Cell-specific p48 DNA-binding Subunit of Pancreas Transcription Factor 1in Cultured Cells Is under Control of Binding Sites for Transcription Factors Sp1 and alpha Cbf
J. Biol. Chem., September 6, 1996; 271(36): 21993 - 22002.
[Abstract] [Full Text] [PDF]




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