Development, Vol 121, Issue 10 3279-3290, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation

D Acampora, S Mazan, Y Lallemand, V Avantaggiato, M Maury, A Simeone and P Brulet
International Institute of Genetics and Biophysics CNR, Naples, Italy.

We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of Otx2. By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. From the early to midstreak stages, endomesodermal cells expressing lacZ fail to be properly localized anteriorly. In the ectodermal layer, lacZ transcription is progressively extinguished, being barely detectable by the late streak stage. These data suggest that Otx2 expression in endomesoderm and ectoderm is required for anterior neuroectoderm specification. In gastrulating heterozygous embryos, a post-transcriptional repression acts on lacZ transcripts in the ectoderm, but not in the external layer, suggesting that different post-transcriptional mechanisms control Otx2 expression in both layers.
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				P. Tam and K. Steiner Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo Development, January 11, 1999; 126(22): 5171 - 5179. [Abstract] [PDF]

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				M Rhinn, A Dierich, M Le Meur, and S Ang Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain Development, January 10, 1999; 126(19): 4295 - 4304. [Abstract] [PDF]

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				K Hentges, K Thompson, and A Peterson The flat-top gene is required for the expansion and regionalization of the telencephalic primordium Development, January 4, 1999; 126(8): 1601 - 1609. [Abstract] [PDF]

				Y Suda, J Nakabayashi, I Matsuo, and S Aizawa Functional equivalency between Otx2 and Otx1 in development of the rostral head Development, January 2, 1999; 126(4): 743 - 757. [Abstract] [PDF]

				H Knoetgen, C Viebahn, and M Kessel Head induction in the chick by primitive endoderm of mammalian, but not avian origin Development, January 2, 1999; 126(4): 815 - 825. [Abstract] [PDF]

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				T. Nagao, S. Leuzinger, D. Acampora, A. Simeone, R. Finkelstein, H. Reichert, and K. Furukubo-Tokunaga Developmental rescue of Drosophila cephalic defects by the human Otx genes PNAS, March 31, 1998; 95(7): 3737 - 3742. [Abstract] [Full Text] [PDF]

				M Belaoussoff, S. Farrington, and M. Baron Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo Development, January 12, 1998; 125(24): 5009 - 5018. [Abstract] [PDF]

				D Acampora, V Avantaggiato, F Tuorto, P Briata, G Corte, and A Simeone Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation Development, January 12, 1998; 125(24): 5091 - 5104. [Abstract] [PDF]

				K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain Development, January 11, 1998; 125(21): 4273 - 4282. [Abstract] [PDF]

				D Dufort, L Schwartz, K Harpal, and J Rossant The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis Development, January 8, 1998; 125(16): 3015 - 3025. [Abstract] [PDF]

				M Hallonet, T Hollemann, R Wehr, N. Jenkins, N. Copeland, T Pieler, and P Gruss Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain Development, January 7, 1998; 125(14): 2599 - 2610. [Abstract] [PDF]

				D. Rowitch, Y Echelard, P. Danielian, K Gellner, S Brenner, and A. McMahon Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate Development, January 7, 1998; 125(14): 2735 - 2746. [Abstract] [PDF]

				D Acampora, V Avantaggiato, F Tuorto, P Barone, H Reichert, R Finkelstein, and A Simeone Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development Development, January 5, 1998; 125(9): 1691 - 1702. [Abstract] [PDF]

				S Leuzinger, F Hirth, D Gerlich, D Acampora, A Simeone, W. Gehring, R Finkelstein, K Furukubo-Tokunaga, and H Reichert Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila Development, January 5, 1998; 125(9): 1703 - 1710. [Abstract] [PDF]

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				C. Sirard, J. L. de la Pompa, A. Elia, A. Itie, C. Mirtsos, A. Cheung, S. Hahn, A. Wakeham, L. Schwartz, S. E. Kern, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo Genes & Dev., January 1, 1998; 12(1): 107 - 119. [Abstract] [Full Text]

				P. Bovolenta, A. Mallamaci, P. Briata, G. Corte, and E. Boncinelli Implication of OTX2 in Pigment Epithelium Determination and Neural Retina Differentiation J. Neurosci., June 1, 1997; 17(11): 4243 - 4252. [Abstract] [Full Text] [PDF]

				I Bach, C Carriere, H P Ostendorff, B Andersen, and M G Rosenfeld A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes & Dev., June 1, 1997; 11(11): 1370 - 1380. [Abstract] [PDF]

				T. Furukawa, C. A. Kozak, and C. L. Cepko rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina PNAS, April 1, 1997; 94(7): 3088 - 3093. [Abstract] [Full Text] [PDF]

				S C Farmer, C W Sun, G E Winnier, B L Hogan, and T M Townes The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes & Dev., March 15, 1997; 11(6): 786 - 798. [Abstract] [PDF]

				R Wehr, A Mansouri, T de Maeyer, and P Gruss Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body Development, January 11, 1997; 124(22): 4447 - 4456. [Abstract] [PDF]

				M Epstein, G Pillemer, R Yelin, J. Yisraeli, and A Fainsod Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes Development, January 10, 1997; 124(19): 3805 - 3814. [Abstract] [PDF]

				C Kimura, N Takeda, M Suzuki, M Oshimura, S Aizawa, and I Matsuo Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells Development, January 10, 1997; 124(20): 3929 - 3941. [Abstract] [PDF]

				D Acampora, V Avantaggiato, F Tuorto, and A Simeone Genetic control of brain morphogenesis through Otx gene dosage requirement Development, January 9, 1997; 124(18): 3639 - 3650. [Abstract] [PDF]

				K. Wassarman, M Lewandoski, K Campbell, A. Joyner, J. Rubenstein, S Martinez, and G. Martin Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function Development, January 8, 1997; 124(15): 2923 - 2934. [Abstract] [PDF]

				H Popperl, C Schmidt, V Wilson, C. Hume, J Dodd, R Krumlauf, and R. Beddington Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm Development, January 8, 1997; 124(15): 2997 - 3005. [Abstract] [PDF]

				M. Fan and S. Sokol A role for Siamois in Spemann organizer formation Development, January 7, 1997; 124(13): 2581 - 2589. [Abstract] [PDF]