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Development, Vol 121, Issue 10 3291-3301, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
C Oka, T Nakano, A Wakeham, JL de la Pompa, C Mori, T Sakai, S Okazaki, M Kawaichi, K Shiota, TW Mak and T Honjo
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
The RBP-J kappa protein is a transcription factor that recognizes the sequence C(T)GTGGGGA. The RBP-J kappa gene is highly conserved in a wide variety of species and the Drosophila homologue has been shown to be identical to Suppressor of Hairless [Su(H)] which plays important roles in the development of the peripheral nervous system. To explore the function of the RBP-J kappa gene in mouse embryogenesis, a mutation was introduced into the functional RBP-J kappa gene in embryonic stem (ES) cells by homologous recombination. Null mutant ES cells survived but null mutant mice showed embryonic lethality before 10.5 days of gestation. The mutant mice showed severe growth retardation as early as 8.5 days of gestation. Developmental abnormalities, including incomplete turning of the body axis, microencephaly, abnormal placental development, anterior neuropore opening and defective somitogenesis, were observed in the mutant mice at 9.5 days of gestation. RBP-J kappa mutant embryos expressed a posterior mesodermal marker FGFR1. Their irregularly shaped somites expressed a somite marker gene Mox 1 but failed to express myogenin. The RBP-J kappa gene was revealed to be essential for postimplantation development of mice.
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T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 13, 2001; (2001) 161269998. [Abstract] [Full Text] [PDF]
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Z. Tang and T. Kadesch Identification of a novel activation domain in the Notch-responsive transcription factor CSL Nucleic Acids Res., June 1, 2001; 29(11): 2284 - 2291. [Abstract] [Full Text] [PDF]
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S. Tani, H. Kurooka, T. Aoki, N. Hashimoto, and T. Honjo The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription Nucleic Acids Res., March 15, 2001; 29(6): 1373 - 1380. [Abstract] [Full Text] [PDF]
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S. Ansieau, L. J. Strobl, and A. Leutz Activation of the Notch-regulated transcription factor CBF1/RBP-J{kappa} through the 13SE1A oncoprotein Genes & Dev., February 15, 2001; 15(4): 380 - 385. [Abstract] [Full Text]
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E Hirsinger, P Malapert, J Dubrulle, M. Delfini, D Duprez, D Henrique, D Ish-Horowicz, and O Pourquie Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation Development, January 1, 2001; 128(1): 107 - 116. [Abstract] [PDF]
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J. K. Yoon and B. Wold The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm Genes & Dev., December 15, 2000; 14(24): 3204 - 3214. [Abstract] [Full Text]
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R. Kopan and A. Goate A common enzyme connects Notch signaling and Alzheimer's disease Genes & Dev., November 15, 2000; 14(22): 2799 - 2806. [Full Text]
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S. A. Holley, R. Geisler, and C. Nüsslein-Volhard Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity Genes & Dev., July 1, 2000; 14(13): 1678 - 1690. [Abstract] [Full Text]
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D. B. Donoviel, A.-K. Hadjantonakis, M. Ikeda, H. Zheng, P. S. G. Hyslop, and A. Bernstein Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects Genes & Dev., November 1, 1999; 13(21): 2801 - 2810. [Abstract] [Full Text]
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W.-C. Jen, V. Gawantka, N. Pollet, C. Niehrs, and C. Kintner Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos Genes & Dev., June 1, 1999; 13(11): 1486 - 1499. [Abstract] [Full Text]
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K. Kuroda, S. Tani, K. Tamura, S. Minoguchi, H. Kurooka, and T. Honjo Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis J. Biol. Chem., March 12, 1999; 274(11): 7238 - 7244. [Abstract] [Full Text] [PDF]
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Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF]
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C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
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J. J.-D. Hsieh, S. Zhou, L. Chen, D. B. Young, and S. D. Hayward CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex PNAS, January 5, 1999; 96(1): 23 - 28. [Abstract] [Full Text] [PDF]
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L. T. Lam and E. H. Bresnick Identity of the beta -Globin Locus Control Region Binding Protein HS2NF5 as the Mammalian Homolog of the Notch-regulated Transcription Factor Suppressor of Hairless J. Biol. Chem., September 11, 1998; 273(37): 24223 - 24231. [Abstract] [Full Text] [PDF]
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D. Sparrow, W. Jen, S Kotecha, N Towers, C Kintner, and T. Mohun Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway Development, January 6, 1998; 125(11): 2041 - 2051. [Abstract] [PDF]
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Y. Taniguchi, T. Furukawa, T. Tun, H. Han, and T. Honjo LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein Mol. Cell. Biol., January 1, 1998; 18(1): 644 - 654. [Abstract] [Full Text]
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Y Saga, N Hata, H Koseki, and M M Taketo Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes & Dev., July 15, 1997; 11(14): 1827 - 1839. [Abstract] [PDF]
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H Kato, Y Taniguchi, H Kurooka, S Minoguchi, T Sakai, S Nomura-Okazaki, K Tamura, and T Honjo Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives Development, January 10, 1997; 124(20): 4133 - 4141. [Abstract] [PDF]
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S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Development, January 8, 1997; 124(16): 3065 - 3076. [Abstract] [PDF]
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T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4 Development, January 4, 1997; 124(8): 1473 - 1483. [Abstract] [PDF]
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J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]
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W. Jen, D Wettstein, D Turner, A Chitnis, and C Kintner The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos Development, January 3, 1997; 124(6): 1169 - 1178. [Abstract] [PDF]
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Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 205 - 216. [Abstract] [PDF]
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S Christensen, V Kodoyianni, M Bosenberg, L Friedman, and J Kimble lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H) Development, January 5, 1996; 122(5): 1373 - 1383. [Abstract] [PDF]
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L. T. Lam, C. Ronchini, J. Norton, A. J. Capobianco, and E. H. Bresnick Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1 J. Biol. Chem., June 23, 2000; 275(26): 19676 - 19684. [Abstract] [Full Text] [PDF]
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T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 31, 2001; 98(16): 9026 - 9031. [Abstract] [Full Text] [PDF]
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