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Development, Vol 121, Issue 10 3439-3446, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
X Yin, M Watanabe and U Rutishauser
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.
We have demonstrated previously that the polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) can regulate peripheral nerve branching during development. In particular, it was found that specific enzymatic removal of PSA from motor axons causes them to form tight fascicles that are less responsive to normal guidance cues. In the present study, the role of PSA in the behavior of axons in the central nervous system has been examined through an analysis of chick optic axons during development. Unlike peripheral axons, which generally grow in a PSA-free environment, PSA was found to be present both on retinal ganglion cell axons and their environment in the tract and tectum. Furthermore, the enzymatic removal of PSA from the optic axons caused them to defasciculate in the tract/tectal region. This response was morphologically similar to targeting corrections made by these axons at a later stage when PSA levels have decreased, suggesting that the PSA may serve to shield them from responding prematurely to some guidance cues in their target region.
This article has been cited by other articles:
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  A. K. Canger and U. Rutishauser Alteration of neural tissue structure by expression of polysialic acid induced by viral delivery of PST polysialyltransferase Glycobiology, January 1, 2004; 14(1): 83 - 93. [Abstract] [Full Text] [PDF]
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 B. Rolf, M. Bastmeyer, M. Schachner, and U. Bartsch Pathfinding Errors of Corticospinal Axons in Neural Cell Adhesion Molecule-Deficient Mice J. Neurosci., October 1, 2002; 22(19): 8357 - 8362. [Abstract] [Full Text] [PDF]
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F. Rashid-Doubell, I. McKinnell, A. R. Aricescu, G. Sajnani, and A. Stoker Chick PTPsigma Regulates the Targeting of Retinal Axons within the Optic Tectum J. Neurosci., June 15, 2002; 22(12): 5024 - 5033. [Abstract] [Full Text] [PDF]
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 M. Marx, U. Rutishauser, and M. Bastmeyer Dual function of polysialic acid during zebrafish central nervous system development Development, December 15, 2001; 128(24): 4949 - 4958. [Abstract] [Full Text] [PDF]
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N. Yamamoto, K. Inui, Y. Matsuyama, A. Harada, K. Hanamura, F. Murakami, E. S. Ruthazer, U. Rutishauser, and T. Seki Inhibitory Mechanism by Polysialic Acid for Lamina-Specific Branch Formation of Thalamocortical Axons J. Neurosci., December 15, 2000; 20(24): 9145 - 9151. [Abstract] [Full Text] [PDF]
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T. Seki and U. Rutishauser Removal of Polysialic Acid-Neural Cell Adhesion Molecule Induces Aberrant Mossy Fiber Innervation and Ectopic Synaptogenesis in the Hippocampus J. Neurosci., May 15, 1998; 18(10): 3757 - 3766. [Abstract] [Full Text] [PDF]
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H. Shen, M. Watanabe, H. Tomasiewicz, U. Rutishauser, T. Magnuson, and J. D. Glass Role of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function J. Neurosci., July 1, 1997; 17(13): 5221 - 5229. [Abstract] [Full Text] [PDF]
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