|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 11 3519-3527, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
JE Treisman and GM Rubin
Department of Molecular and Cell Biology, UC Berkeley 94720, USA.
Differentiation of the Drosophila eye imaginal disc is an asynchronous, repetitive process which proceeds across the disc from posterior to anterior. Its propagation correlates with the expression of decapentaplegic at the front of differentiation, in the morphogenetic furrow. Both differentiation and decapentaplegic expression are maintained by Hedgehog protein secreted by the differentiated cells posterior to the furrow. However, their initiation at the posterior margin occurs prior to hedgehog expression by an unknown mechanism. We show here that the wingless gene contributes to the correct spatial localization of initiation. Initiation of the morphogenetic furrow is restricted to the posterior margin by the presence of wingless at the lateral margins; removal of wingless allows lateral initiation. Ectopic expression of wingless at the posterior margin can also inhibit normal initiation. In addition, the presence of wingless in the center of the disc can prevent furrow progression. These effects of wingless are achieved without altering the expression of decapentaplegic.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Song, K. R. Schwab, L. T. Patterson, T. Yamaguchi, X. Lin, S. S. Potter, and R. A. Lang pygopus 2 has a crucial, Wnt pathway-independent function in lens induction Development, May 15, 2007; 134(10): 1873 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Erezyilmaz Imperfect eggs and oviform nymphs: a history of ideas about the origins of insect metamorphosis Integr. Comp. Biol., December 1, 2006; 46(6): 795 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, X. Shi, and K.-W. Choi Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development, December 1, 2006; 133(23): 4771 - 4781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Ekas, G.-H. Baeg, M. S. Flaherty, A. Ayala-Camargo, and E. A. Bach JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila Development, December 1, 2006; 133(23): 4721 - 4729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bras-Pereira, J. Bessa, and F. Casares Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila Development, November 1, 2006; 133(21): 4145 - 4149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Lim and A. Tomlinson Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis Development, September 15, 2006; 133(18): 3529 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Cho and C. L. Cepko Wnt2b/{beta}-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye Development, August 15, 2006; 133(16): 3167 - 3177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jones, R. Reifegerste, and K. Moses Characterization of Drosophila mini-me, a Gene Required for Cell Proliferation and Survival Genetics, June 1, 2006; 173(2): 793 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rogers, C. A. Brennan, N. T. Mortimer, S. Cook, A. R. Morris, and K. Moses Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow Development, November 1, 2005; 132(21): 4833 - 4843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ouchi, Y. Tabata, K.-i. Arai, and S. Watanabe Negative regulation of retinal-neurite extension by {beta}-catenin signaling pathway J. Cell Sci., October 1, 2005; 118(19): 4473 - 4483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, J. Chan, J. J. Chern, and K.-W. Choi Genetic Interaction of Lobe With Its Modifiers in Dorsoventral Patterning and Growth of the Drosophila Eye Genetics, September 1, 2005; 171(1): 169 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Pappu, E. J. Ostrin, B. W. Middlebrooks, B. T. Sili, R. Chen, M. R. Atkins, R. Gibbs, and G. Mardon Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund Development, June 15, 2005; 132(12): 2895 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Grzeschik and E. Knust IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherin Development, May 1, 2005; 132(9): 2035 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. T. Cox and M. K. Baylies Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling Development, February 15, 2005; 132(4): 713 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Silver and I. Rebay Signaling circuitries in development: insights from the retinal determination gene network Development, January 1, 2005; 132(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Kumar, T. Jamal, A. Doetsch, F. R. Turner, and J. B. Duffy CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila Genetics, October 1, 2004; 168(2): 877 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Treisman How to make an eye Development, August 15, 2004; 131(16): 3823 - 3827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Janody, J. D. Lee, N. Jahren, D. J. Hazelett, A. Benlali, G. I. Miura, I. Draskovic, and J. E. Treisman A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development Genetics, January 1, 2004; 166(1): 187 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thomas and P. W. Ingham Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes Genetics, December 1, 2003; 165(4): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Friedrich Evolution of Insect Eye Development: First Insights from Fruit Fly, Grasshopper and Flour Beetle Integr. Comp. Biol., August 1, 2003; 43(4): 508 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Lin, D. B. Doroquez, S. Cho, F. Chen, I. Rebay, and K. M. Cadigan Splits ends is a tissue/promoter specific regulator of Wingless signaling Development, July 15, 2003; 130(14): 3125 - 3135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development Development, July 1, 2003; 130(13): 2939 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Pappu, R. Chen, B. W. Middlebrooks, C. Woo, U. Heberlein, and G. Mardon Mechanism of hedgehog signaling during Drosophila eye development Development, July 1, 2003; 130(13): 3053 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms Development, March 14, 2003; 129(24): 5697 - 5706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, M. Kango-Singh, and Y. H. Sun Eye suppression, a novel function of teashirt, requires Wingless signaling Development, March 11, 2003; 129(18): 4271 - 4280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Cadigan, A. D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development, March 9, 2003; 129(14): 3393 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bessa, B. Gebelein, F. Pichaud, F. Casares, and R. S. Mann Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt Genes & Dev., September 15, 2002; 16(18): 2415 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Chern and K.-W. Choi Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc Development, September 1, 2002; 129(17): 4005 - 4013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, A. Friedman, S. Heaney, P. Purcell, and R. L. Maas Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis Genes & Dev., August 15, 2002; 16(16): 2097 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Saller, A. Kelley, and M. Bienz The transcriptional repressor Brinker antagonizes Wingless signaling Genes & Dev., July 15, 2002; 16(14): 1828 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baonza and M. Freeman Control of Drosophila eye specification by Wingless signalling Development, January 12, 2002; 129(23): 5313 - 5322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ahmed, A. Nouri, and E. Wieschaus Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development Development, January 4, 2002; 129(7): 1751 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Kumar and K. Moses The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow during Drosophila eye development Development, July 15, 2001; 128(14): 2689 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee and J. Treisman The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc Development, January 5, 2001; 128(9): 1519 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]
|
|
|
|
|
|
I. Rebay, F. Chen, F. Hsiao, P. A. Kolodziej, B. H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G. M. Rubin A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein Genetics, February 1, 2000; 154(2): 695 - 712. [Abstract] [Full Text]
|
|
|
|
|
|
C Maurel-Zaffran and J. Treisman pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila Development, January 3, 2000; 127(5): 1007 - 1016. [Abstract] [PDF]
|
|
|
|
|
|
S. Greaves, B. Sanson, P. White, and J.-P. Vincent A Screen for Identifying Genes Interacting With Armadillo, the Drosophila Homolog of {beta}-Catenin Genetics, December 1, 1999; 153(4): 1753 - 1766. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Haug-Collet, B. Pearson, R. Webel, R.T. Szerencsei, R.J. Winkfein, P.P.M. Schnetkamp, and N.J. Colley Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila J. Cell Biol., November 1, 1999; 147(3): 659 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Zeidler, N. Perrimon, and D. I. Strutt Polarity determination in the Drosophila eye: a novel role for Unpaired and JAK/STAT signaling Genes & Dev., May 15, 1999; 13(10): 1342 - 1353. [Abstract] [Full Text]
|
|
|
|
|
|
K. McCabe, E. Gunther, and T. Reh The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation Development, January 12, 1999; 126(24): 5713 - 5724. [Abstract] [PDF]
|
|
|
|
|
|
F Cavodeassi, R Diez Del Corral, S Campuzano, and M Dominguez Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins Development, January 11, 1999; 126(22): 4933 - 4942. [Abstract] [PDF]
|
|
|
|
|
|
A Amin, Y Li, and R Finkelstein Hedgehog activates the EGF receptor pathway during Drosophila head development Development, January 6, 1999; 126(12): 2623 - 2630. [Abstract] [PDF]
|
|
|
|
|
|
R Chen, G Halder, Z Zhang, and G Mardon Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila Development, January 2, 1999; 126(5): 935 - 943. [Abstract] [PDF]
|
|
|
|
|
|
C.-Y. Pai, T.-S. Kuo, T. J. Jaw, E. Kurant, C.-T. Chen, D. A. Bessarab, A. Salzberg, and Y. H. Sun The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila Genes & Dev., February 1, 1998; 12(3): 435 - 446. [Abstract] [Full Text]
|
|
|
|
|
|
J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation Development, January 10, 1998; 125(19): 3875 - 3885. [Abstract] [PDF]
|
|
|
|
|
|
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc Development, January 9, 1998; 125(18): 3741 - 3751. [Abstract] [PDF]
|
|
|
|
|
|
J Zhang and R. Carthew Interactions between Wingless and DFz2 during Drosophila wing development Development, January 8, 1998; 125(16): 3075 - 3085. [Abstract] [PDF]
|
|
|
|
|
|
G Halder, P Callaerts, S Flister, U Walldorf, U Kloter, and W. Gehring Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development Development, January 6, 1998; 125(12): 2181 - 2191. [Abstract] [PDF]
|
|
|
|
|
|
M Wehrli and A Tomlinson Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis Development, January 4, 1998; 125(8): 1421 - 1432. [Abstract] [PDF]
|
|
|
|
|
|
P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling Development, January 4, 1998; 125(8): 1519 - 1528. [Abstract] [PDF]
|
|
|
|
|
|
E Kurant, C. Pai, R Sharf, N Halachmi, Y. Sun, and A Salzberg Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS Development, January 3, 1998; 125(6): 1037 - 1048. [Abstract] [PDF]
|
|
|
|
|
|
P Rorth, K Szabo, A Bailey, T Laverty, J Rehm, G. Rubin, K Weigmann, M Milan, V Benes, W Ansorge, et al. Systematic gain-of-function genetics in Drosophila Development, January 3, 1998; 125(6): 1049 - 1057. [Abstract] [PDF]
|
|
|
|
|
|
U Heberlein, E. Borod, and F. Chanut Dorsoventral patterning in the Drosophila retina by wingless Development, January 2, 1998; 125(4): 567 - 577. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins Genes & Dev., August 1, 1997; 11(15): 1949 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Royet and R Finkelstein Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog Development, January 12, 1997; 124(23): 4793 - 4800. [Abstract] [PDF]
|
|
|
|
|
|
A Tomlinson, W. Strapps, and J Heemskerk Linking Frizzled and Wnt signaling in Drosophila development Development, January 11, 1997; 124(22): 4515 - 4521. [Abstract] [PDF]
|
|
|
|
|
|
D. Strutt and M Mlodzik Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc Development, January 9, 1997; 124(17): 3233 - 3240. [Abstract] [PDF]
|
|
|
|
|
|
T. Heslip, H Theisen, H Walker, and J. Marsh Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs Development, January 3, 1997; 124(5): 1069 - 1078. [Abstract] [PDF]
|
|
|
|
|
|
W Shen and G Mardon Ectopic eye development in Drosophila induced by directed dachshund expression Development, January 1, 1997; 124(1): 45 - 52. [Abstract] [PDF]
|
|
|
|
|
|
F Pignoni and S. Zipursky Induction of Drosophila eye development by decapentaplegic Development, January 1, 1997; 124(2): 271 - 278. [Abstract] [PDF]
|
|
|
|
|
|
F Chanut and U Heberlein Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina Development, January 1, 1997; 124(2): 559 - 567. [Abstract] [PDF]
|
|
|
|
|
|
V. Wiersdorff, T. Lecuit, S. M. Cohen, and M. Mlodzik Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye Development, July 1, 1996; 122(7): 2153 - 2162. [Abstract] [PDF]
|
|
|
|
|
|
H Theisen, T. Haerry, M. O'Connor, and J. Marsh Developmental territories created by mutual antagonism between Wingless and Decapentaplegic Development, January 12, 1996; 122(12): 3939 - 3948. [Abstract] [PDF]
|
|
|
|
|
|
C. Neumann and S. Cohen A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing Development, January 11, 1996; 122(11): 3477 - 3485. [Abstract] [PDF]
|
|
|
|
|
|
K. Cadigan and R Nusse wingless signaling in the Drosophila eye and embryonic epidermis Development, January 9, 1996; 122(9): 2801 - 2812. [Abstract] [PDF]
|
|
|
|
|
|
F Chanut and U Heberlein Role of the morphogenetic furrow in establishing polarity in the Drosophila eye Development, January 12, 1995; 121(12): 4085 - 4094. [Abstract] [PDF]
|
|
