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Development, Vol 121, Issue 11 3529-3537, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Lack of beta-catenin affects mouse development at gastrulation

H Haegel, L Larue, M Ohsugi, L Fedorov, K Herrenknecht and R Kemler
Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.

Molecular analysis of the cadherin-catenin complex elucidated the central role of beta-catenin in this adhesion complex, as it binds to the cytoplasmic domain of E-cadherin and to alpha-catenin. beta-Catenin may also function in signalling pathways, given its homology to the gene product of the Drosophila segment polarity gene armadillo, which is known to be involved in the wingless signalling cascade. To study the function of beta-catenin during mouse development, gene knock-out experiments were performed in embryonic stem cells and transgenic mice were generated. beta-Catenin null-mutant embryos formed blastocysts, implanted and developed into egg-cylinder-stage embryos. At day 7 post coitum, the development of the embryonic ectoderm was affected in mutant embryos. Cells detached from the ectodermal cell layer and were dispersed into the proamniotic cavity. No mesoderm formation was observed in mutant embryos. The development of extraembryonic structures appeared less dramatically or not at all affected. Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer.
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 GeneticsHome page
L. Natarajan, N. E. Witwer, and D. M. Eisenmann
The Divergent Caenorhabditis elegans {beta}-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy in Vivo
Genetics, September 1, 2001; 159(1): 159 - 172.
[Abstract] [Full Text] [PDF]

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 JCBHome page
A. Imbert, R. Eelkema, S. Jordan, H. Feiner, and P. Cowin
{Delta}n89{beta}-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland
J. Cell Biol., April 30, 2001; 153(3): 555 - 568.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
L. Snider, H. Thirlwell, J. R. Miller, R. T. Moon, M. Groudine, and S. J. Tapscott
Inhibition of Tcf3 Binding by I-mfa Domain Proteins
Mol. Cell. Biol., March 1, 2001; 21(5): 1866 - 1873.
[Abstract] [Full Text]

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 DevelopmentHome page
V Brault, R Moore, S Kutsch, M Ishibashi, D. Rowitch, A. McMahon, L Sommer, O Boussadia, and R Kemler
Inactivation of the (&bgr;)-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
Development, January 4, 2001; 128(8): 1253 - 1264.
[Abstract] [PDF]

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 CROBMHome page
L. Lo Muzio
A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis
Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(2): 152 - 165.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
W. M. Blankesteijn, M. E. van Gijn, Y. P. G. Essers-Janssen, M. J. A. P. Daemen, and J. F. M. Smits
{beta}-Catenin, an Inducer of Uncontrolled Cell Proliferation and Migration in Malignancies, Is Localized in the Cytoplasm of Vascular Endothelium during Neovascularization after Myocardial Infarction
Am. J. Pathol., September 1, 2000; 157(3): 877 - 883.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev
Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by beta -Catenin and Plakoglobin
Mol. Cell. Biol., June 15, 2000; 20(12): 4238 - 4252.
[Abstract] [Full Text]

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 Arterioscler. Thromb. Vasc. Bio.Home page
G. Balconi, R. Spagnuolo, and E. Dejana
Development of Endothelial Cell Lines From Embryonic Stem Cells : A Tool for Studying Genetically Manipulated Endothelial Cells In Vitro
Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1443 - 1451.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
F. T. Kolligs, B. Kolligs, K. M. Hajra, G. Hu, M. Tani, K. R. Cho, and E. R. Fearon
gamma -Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta -catenin
Genes & Dev., June 1, 2000; 14(11): 1319 - 1331.
[Abstract] [Full Text]

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 JCBHome page
E. Charpentier, R. M. Lavker, E. Acquista, and P. Cowin
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo
J. Cell Biol., April 17, 2000; 149(2): 503 - 520.
[Abstract] [Full Text] [PDF]

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 JCBHome page
J. Huelsken, R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier
Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice
J. Cell Biol., February 7, 2000; 148(3): 567 - 578.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
J Zhurinsky, M Shtutman, and A Ben-Ze'ev
Plakoglobin and beta-catenin: protein interactions, regulation and biological roles
J. Cell Sci., January 9, 2000; 113(18): 3127 - 3139.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
S. Kodama, S. Ikeda, T. Asahara, M. Kishida, and A. Kikuchi
Axin Directly Interacts with Plakoglobin and Regulates Its Stability
J. Biol. Chem., September 24, 1999; 274(39): 27682 - 27688.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
J. Cerdà, S. Reidenbach, S. Prätzel, and W. W. Franke
Cadherin-Catenin Complexes During Zebrafish Oogenesis: Heterotypic Junctions Between Oocytes and Follicle Cells
Biol Reprod, September 1, 1999; 61(3): 692 - 704.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
V. Vasioukhin, L. Degenstein, B. Wise, and E. Fuchs
The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
PNAS, July 20, 1999; 96(15): 8551 - 8556.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Hecht, C. M. Litterst, O. Huber, and R. Kemler
Functional Characterization of Multiple Transactivating Elements in beta -Catenin, Some of Which Interact with the TATA-binding Protein in Vitro
J. Biol. Chem., June 18, 1999; 274(25): 18017 - 18025.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
E. Pötter, C. Bergwitz, and G. Brabant
The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues
Endocr. Rev., April 1, 1999; 20(2): 207 - 239.
[Abstract] [Full Text]

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 DevelopmentHome page
C. Logan, J. Miller, M. Ferkowicz, and D. McClay
Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo
Development, January 1, 1999; 126(2): 345 - 357.
[Abstract] [PDF]

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 JCBHome page
G. I. Gallicano, P. Kouklis, C. Bauer, M. Yin, V. Vasioukhin, L. Degenstein, and E. Fuchs
Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage
J. Cell Biol., December 28, 1998; 143(7): 2009 - 2022.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. Gotz, A. Probst, E. Ehler, B. Hemmings, and W. Kues
Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha
PNAS, October 13, 1998; 95(21): 12370 - 12375.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
D. L. Benson and H. Tanaka
N-Cadherin Redistribution during Synaptogenesis in Hippocampal Neurons
J. Neurosci., September 1, 1998; 18(17): 6892 - 6904.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
J. A. Efstathiou and M. Pignatelli
Modulation of Epithelial Cell Adhesion in Gastrointestinal Homeostasis
Am. J. Pathol., August 1, 1998; 153(2): 341 - 347.
[Full Text] [PDF]

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 JCBHome page
I. Simcha, M. Shtutman, D. Salomon, J. Zhurinsky, E. Sadot, B. Geiger, and A. Ben-Ze'ev
Differential Nuclear Translocation and Transactivation Potential of {beta}-Catenin and Plakoglobin
J. Cell Biol., June 15, 1998; 141(6): 1433 - 1448.
[Abstract] [Full Text] [PDF]

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 JCBHome page
M. H. Wong, B. Rubinfeld, and J. I. Gordon
Effects of Forced Expression of an NH2-terminal Truncated {beta}-Catenin on Mouse Intestinal Epithelial Homeostasis
J. Cell Biol., May 4, 1998; 141(3): 765 - 777.
[Abstract] [Full Text] [PDF]

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 JCBHome page
M. Costa, W. Raich, C. Agbunag, B. Leung, J. Hardin, and J. R. Priess
A Putative Catenin-Cadherin System Mediates Morphogenesis of the Caenorhabditis elegans Embryo
J. Cell Biol., April 6, 1998; 141(1): 297 - 308.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
Z. Gu, M. Nomura, B. B. Simpson, H. Lei, A. Feijen, J. van den Eijnden-van Raaij, P. K. Donahoe, and E. Li
The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
Genes & Dev., March 15, 1998; 12(6): 844 - 857.
[Abstract] [Full Text]

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 JCBHome page
P. White, H. Aberle, and J.-P. Vincent
Signaling and Adhesion Activities of Mammalian {beta}-Catenin and Plakoglobin in Drosophila
J. Cell Biol., January 12, 1998; 140(1): 183 - 195.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Tang, P. Hoodless, Z Lu, M. Breitman, R. McInnes, J. Wrana, and M Buchwald
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
Development, January 5, 1998; 125(10): 1877 - 1887.
[Abstract] [PDF]


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