|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 11 3561-3572, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
J Royet and R Finkelstein
University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia 19104, USA.
Significant progress has been made towards understanding how pattern formation occurs in the imaginal discs that give rise to the limbs of Drosophila melanogaster. Here, we examine the process of regional specification that occurs in the eye-antennal discs, which form the head of the adult fruitfly. We demonstrate genetically that there is a graded requirement for the activity of the orthodenticle homeobox gene in forming specific structures of the developing head. Consistent with this result, we show that OTD protein is expressed in a graded fashion across the disc primordia of these structures and that different threshold levels of OTD are required for the formation of specific subdomains of the head. Finally, we provide evidence suggesting that otd acts through the segment polarity gene engrailed to specify medial head development.
This article has been cited by other articles:
|
|
 |
|
  S. J. Macdonald and A. D. Long Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster Genetics, June 1, 2007; 176(2): 1261 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bucher and M. Klingler Divergent segmentation mechanism in the short germ insect Tribolium revealed by giant expression and function Development, April 15, 2004; 131(8): 1729 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Friedrich Evolution of Insect Eye Development: First Insights from Fruit Fly, Grasshopper and Flour Beetle Integr. Comp. Biol., August 1, 2003; 43(4): 508 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu Patterning of the mammalian cochlea PNAS, October 24, 2000; 97(22): 11707 - 11713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Breen Mutant Alleles of the Drosophila trithorax Gene Produce Common and Unusual Homeotic and Other Developmental Phenotypes Genetics, May 1, 1999; 152(1): 319 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu Otx1 and Otx2 activities are required for the normal development of the mouse inner ear Development, January 6, 1999; 126(11): 2335 - 2343. [Abstract] [PDF]
|
|
|
|
|
|
T. Nagao, S. Leuzinger, D. Acampora, A. Simeone, R. Finkelstein, H. Reichert, and K. Furukubo-Tokunaga Developmental rescue of Drosophila cephalic defects by the human Otx genes PNAS, March 31, 1998; 95(7): 3737 - 3742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Acampora, V Avantaggiato, F Tuorto, P Barone, H Reichert, R Finkelstein, and A Simeone Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development Development, January 5, 1998; 125(9): 1691 - 1702. [Abstract] [PDF]
|
|
|
|
|
|
S Leuzinger, F Hirth, D Gerlich, D Acampora, A Simeone, W. Gehring, R Finkelstein, K Furukubo-Tokunaga, and H Reichert Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila Development, January 5, 1998; 125(9): 1703 - 1710. [Abstract] [PDF]
|
|
|
|
|
|
J Royet and R Finkelstein Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog Development, January 12, 1997; 124(23): 4793 - 4800. [Abstract] [PDF]
|
|
|
|
|
|
D Acampora, V Avantaggiato, F Tuorto, and A Simeone Genetic control of brain morphogenesis through Otx gene dosage requirement Development, January 9, 1997; 124(18): 3639 - 3650. [Abstract] [PDF]
|
|
|
|
|
|
L. Gammill and H Sive Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation Development, January 1, 1997; 124(2): 471 - 481. [Abstract] [PDF]
|
|
|
|
|
|
S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts Development, January 12, 1996; 122(12): 3785 - 3797. [Abstract] [PDF]
|
|
|
|
|
|
J Royet and R Finkelstein hedgehog, wingless and orthodenticle specify adult head development in Drosophila Development, January 6, 1996; 122(6): 1849 - 1858. [Abstract] [PDF]
|
|
|
|
|
|
C. Mao, A. Wikramanayake, L Gan, C. Chuang, R. Summers, and W. Klein Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein Development, January 5, 1996; 122(5): 1489 - 1498. [Abstract] [PDF]
|
|
