|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 11 3637-3650, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
CP Austin, DE Feldman, JA Ida and CL Cepko
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
The first cells generated during development of the vertebrate retina are the ganglion cells, the projection neurons of the retina. Although they are one of the most intensively studied cell types within the central nervous system, little is known of the mechanisms that determine ganglion cell fate. We demonstrate that ganglion cells are selected from a large group of competent progenitors that comprise the majority of the early embryonic retina and that differentiation within this group is regulated by Notch. Notch activity in vivo was diminished using antisense oligonucleotides or augmented using a retrovirally transduced constitutively active allele of Notch. The number of ganglion cells produced was inversely related to the level of Notch activity. In addition, the Notch ligand Delta inhibited retinal progenitors from differentiating as ganglion cells to the same degree as did activated Notch in an in vitro assay. These results suggest a conserved strategy for neurogenesis in the retina and describe a versatile in vitro and in vivo system with which to examine the action of the Notch pathway in a specific cell fate decision in a vertebrate.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. N. Riesenberg, Z. Liu, R. Kopan, and N. L. Brown Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina J. Neurosci., October 14, 2009; 29(41): 12865 - 12877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakagami, L. Gan, and X.-J. Yang Distinct Effects of Hedgehog Signaling on Neuronal Fate Specification and Cell Cycle Progression in the Embryonic Mouse Retina J. Neurosci., May 27, 2009; 29(21): 6932 - 6944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Wong and D. H. Rapaport Defining retinal progenitor cell competence in Xenopus laevis by clonal analysis Development, May 15, 2009; 136(10): 1707 - 1715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chatzopoulou, A. Miguez, M. Savvaki, G. Levasseur, A. Muzerelle, M.-P. Muriel, O. Goureau, K. Watanabe, L. Goutebroze, P. Gaspar, et al. Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve J. Neurosci., July 23, 2008; 28(30): 7624 - 7636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Mu, X. Fu, P. D. Beremand, T. L. Thomas, and W. H. Klein Gene-regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2 PNAS, May 13, 2008; 105(19): 6942 - 6947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Das, J. James, S. Bhattacharya, A. N. Imbalzano, M. L. Antony, G. Hegde, X. Zhao, K. Mallya, F. Ahmad, E. Knudsen, et al. SWI/SNF Chromatin Remodeling ATPase Brm Regulates the Differentiation of Early Retinal Stem Cells/Progenitors by Influencing Brn3b Expression and Notch Signaling J. Biol. Chem., November 30, 2007; 282(48): 35187 - 35201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhattacharya, A. Das, K. Mallya, and I. Ahmad Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling J. Cell Sci., August 1, 2007; 120(15): 2652 - 2662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Levesque, S. Zhou, L. Shan, P. Johnston, Y. Kong, S. Degan, and M. E. Sunday NPAS1 Regulates Branching Morphogenesis in Embryonic Lung Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shan, J. C. Aster, J. Sklar, and M. E. Sunday Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L500 - L509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Jadhav, S.-H. Cho, and C. L. Cepko Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property PNAS, December 12, 2006; 103(50): 18998 - 19003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Solter, M. Locker, S. Boy, V. Taelman, E. J. Bellefroid, M. Perron, and T. Pieler Characterization and function of the bHLH-O protein XHes2: insight into the mechanisms controlling retinal cell fate decision Development, October 15, 2006; 133(20): 4097 - 4108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Cho and C. L. Cepko Wnt2b/{beta}-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye Development, August 15, 2006; 133(16): 3167 - 3177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gao and R. H. Miller Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. J. Neurosci., July 19, 2006; 26(29): 7619 - 7628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hashimoto, X.-M. Zhang, B. Y.-k. Chen, and X.-J. Yang VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation Development, June 1, 2006; 133(11): 2201 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. V. Taranova, S. T. Magness, B. M. Fagan, Y. Wu, N. Surzenko, S. R. Hutton, and L. H. Pevny SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes & Dev., May 1, 2006; 20(9): 1187 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Yaron, C. Farhy, T. Marquardt, M. Applebury, and R. Ashery-Padan Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina Development, April 1, 2006; 133(7): 1367 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Jadhav, H. A. Mason, and C. L. Cepko Notch 1 inhibits photoreceptor production in the developing mammalian retina Development, March 1, 2006; 133(5): 913 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, G. D. Dakubo, S. Thurig, C. J. Mazerolle, and V. A. Wallace Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina Development, November 15, 2005; 132(22): 5103 - 5113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kubo, M. Takeichi, and S. Nakagawa Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes Development, June 15, 2005; 132(12): 2759 - 2770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Liu and R. M. Harland Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein Development, April 1, 2005; 132(7): 1511 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Halfter, M. Willem, and U. Mayer Basement Membrane-Dependent Survival of Retinal Ganglion Cells Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 1000 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Xie, R.-T. Yan, W. Ma, and S.-Z. Wang Enhanced Retinal Ganglion Cell Differentiation by ath5 and NSCL1 Coexpression Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 2922 - 2928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S.-M. Zhang, J. Wei, H. Qin, L. Zhang, B. Xie, P. Hui, A. Deisseroth, C. J. Barnstable, and X.-Y. Fu STAT3-Mediated Signaling in the Determination of Rod Photoreceptor Cell Fate in Mouse Retina Invest. Ophthalmol. Vis. Sci., July 1, 2004; 45(7): 2407 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kong, J. Glickman, M. Subramaniam, A. Shahsafaei, K. P. Allamneni, J. C. Aster, J. Sklar, and M. E. Sunday Functional diversity of notch family genes in fetal lung development Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1075 - L1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Mu, P. D. Beremand, S. Zhao, R. Pershad, H. Sun, A. Scarpa, S. Liang, T. L. Thomas, and W. H. Klein Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina Development, March 15, 2004; 131(6): 1197 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. James, A. V. Das, S. Bhattacharya, D. M. Chacko, X. Zhao, and I. Ahmad In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors J. Neurosci., September 10, 2003; 23(23): 8193 - 8203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Esteve, F. Trousse, J. Rodriguez, and P. Bovolenta SFRP1 modulates retina cell differentiation through a {beta}-catenin-independent mechanism J. Cell Sci., June 15, 2003; 116(12): 2471 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Frankfort and G. Mardon R8 development in the Drosophila eye: a paradigm for neural selection and differentiation Development, March 5, 2003; 129(6): 1295 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor Notch1 is required for neuronal and glial differentiation in the cerebellum Development, March 3, 2003; 129(2): 373 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chojnacki, T. Shimazaki, C. Gregg, G. Weinmaster, and S. Weiss Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells J. Neurosci., March 1, 2003; 23(5): 1730 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kubo, M. Takeichi, and S. Nakagawa Wnt2b controls retinal cell differentiation at the ciliary marginal zone Development, February 1, 2003; 130(3): 587 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Eglen and D. J. Willshaw Influence of cell fate mechanisms upon retinal mosaic formation: a modelling study Development, January 12, 2002; 129(23): 5399 - 5408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Adler and T. L. Belecky-Adams The role of bone morphogenetic proteins in the differentiation of the ventral optic cup Development, January 7, 2002; 129(13): 3161 - 3171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Mu, S. Zhao, R. Pershad, T.-F. Hsieh, A. Scarpa, S. W. Wang, R. A. White, P. D. Beremand, T. L. Thomas, L. Gan, et al. Gene expression in the developing mouse retina by EST sequencing and microarray analysis Nucleic Acids Res., December 15, 2001; 29(24): 4983 - 4993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Faux, A. M. Turnley, R. Epa, R. Cappai, and P. F. Bartlett Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation J. Neurosci., August 1, 2001; 21(15): 5587 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Brown, S. Patel, J. Brzezinski, and T. Glaser Math5 is required for retinal ganglion cell and optic nerve formation Development, July 1, 2001; 128(13): 2497 - 2508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Liu, Z. Mo, and M. Xiang The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development PNAS, February 13, 2001; 98(4): 1649 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Scheer, A Groth, S Hans, and J. Campos-Ortega An instructive function for Notch in promoting gliogenesis in the zebrafish retina Development, January 4, 2001; 128(7): 1099 - 1107. [Abstract] [PDF]
|
|
|
|
|
|
X. Zhang and X. Yang Regulation of retinal ganglion cell production by Sonic hedgehog Development, January 3, 2001; 128(6): 943 - 957. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Wang, B. S. Kim, K. Ding, H. Wang, D. Sun, R. L. Johnson, W. H. Klein, and L. Gan Requirement for math5 in the development of retinal ganglion cells Genes & Dev., January 1, 2001; 15(1): 24 - 29. [Abstract] [Full Text]
|
|
|
|
|
|
M Gonzalez-Hoyuela, J. Barbas, and A Rodriguez-Tebar The autoregulation of retinal ganglion cell number Development, January 1, 2001; 128(1): 117 - 124. [Abstract] [PDF]
|
|
|
|
|
|
B. A. Link, J. M. Fadool, J. Malicki, and J. E. Dowling The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells Development, May 15, 2000; 127(10): 2177 - 2188. [Abstract] [PDF]
|
|
|
|
|
|
B. Pimentel, C. Sanz, I. Varela-Nieto, U. R. Rapp, F. De Pablo, and E. J. de la Rosa c-Raf Regulates Cell Survival and Retinal Ganglion Cell Morphogenesis during Neurogenesis J. Neurosci., May 1, 2000; 20(9): 3254 - 3262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Belliveau, T. L. Young, and C. L. Cepko Late Retinal Progenitor Cells Show Intrinsic Limitations in the Production of Cell Types and the Kinetics of Opsin Synthesis J. Neurosci., March 15, 2000; 20(6): 2247 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Schulte and C. Cepko Two homeobox genes define the domain of EphA3 expression in the developing chick retina Development, January 12, 2000; 127(23): 5033 - 5045. [Abstract] [PDF]
|
|
|
|
|
|
T. Maynard, Y Wakamatsu, and J. Weston Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors Development, January 11, 2000; 127(21): 4561 - 4572. [Abstract] [PDF]
|
|
|
|
|
|
M. Rones, K. McLaughlin, M Raffin, and M Mercola Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis Development, January 9, 2000; 127(17): 3865 - 3876. [Abstract] [PDF]
|
|
|
|
|
|
W Liu, S. Khare, X Liang, M. Peters, X Liu, C. Cepko, and M Xiang All Brn3 genes can promote retinal ganglion cell differentiation in the chick Development, January 8, 2000; 127(15): 3237 - 3247. [Abstract] [PDF]
|
|
|
|
|
|
A Zine, T. Van De Water, and F de Ribaupierre Notch signaling regulates the pattern of auditory hair cell differentiation in mammals Development, January 8, 2000; 127(15): 3373 - 3383. [Abstract] [PDF]
|
|
|
|
|
|
Y Wakamatsu, T. Maynard, and J. Weston Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis Development, January 7, 2000; 127(13): 2811 - 2821. [Abstract] [PDF]
|
|
|
|
|
|
B Diaz, J Serna, F De Pablo, and E. de la Rosa In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis Development, January 4, 2000; 127(8): 1641 - 1649. [Abstract] [PDF]
|
|
|
|
|
|
K. McCabe, E. Gunther, and T. Reh The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation Development, January 12, 1999; 126(24): 5713 - 5724. [Abstract] [PDF]
|
|
|
|
|
|
R. Widelitz, T. Jiang, C. Chen, N. Stott, and C. Chuong Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model Development, January 6, 1999; 126(12): 2577 - 2587. [Abstract] [PDF]
|
|
|
|
|
|
M. Belliveau and C. Cepko Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina Development, January 2, 1999; 126(3): 555 - 566. [Abstract] [PDF]
|
|
|
|
|
|
J. Stone and E. Rubel Delta1 expression during avian hair cell regeneration Development, January 2, 1999; 126(5): 961 - 973. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zhao and G Lemke Selective disruption of neuregulin-1 function in vertebrate embryos using ribozyme-tRNA transgenes Development, January 5, 1998; 125(10): 1899 - 1907. [Abstract] [PDF]
|
|
|
|
|
|
S Anant, S Roy, and K VijayRaghavan Twist and Notch negatively regulate adult muscle differentiation in Drosophila Development, January 4, 1998; 125(8): 1361 - 1369. [Abstract] [PDF]
|
|
|
|
|
|
D. Waid and S. McLoon Ganglion cells influence the fate of dividing retinal cells in culture Development, January 3, 1998; 125(6): 1059 - 1066. [Abstract] [PDF]
|
|
|
|
|
|
C Haddon, L Smithers, S Schneider-Maunoury, T Coche, D Henrique, and J Lewis Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis Development, January 2, 1998; 125(3): 359 - 370. [Abstract] [PDF]
|
|
|
|
|
|
B Appel and J. Eisen Regulation of neuronal specification in the zebrafish spinal cord by Delta function Development, January 2, 1998; 125(3): 371 - 380. [Abstract] [PDF]
|
|
|
|
|
|
R Crowe, D Henrique, D Ish-Horowicz, and L Niswander A new role for Notch and Delta in cell fate decisions: patterning the feather array Development, January 2, 1998; 125(4): 767 - 775. [Abstract] [PDF]
|
|
|
|
|
|
E. J. A. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins Genes & Dev., December 1, 1997; 11(23): 3182 - 3193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Z. Liu, L. Q. Zhu, and F. F. Eide Critical Role of TrkB and Brain-Derived Neurotrophic Factor in the Differentiation and Survival of Retinal Pigment Epithelium J. Neurosci., November 15, 1997; 17(22): 8749 - 8755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bovolenta, A. Mallamaci, P. Briata, G. Corte, and E. Boncinelli Implication of OTX2 in Pigment Epithelium Determination and Neural Retina Differentiation J. Neurosci., June 1, 1997; 17(11): 4243 - 4252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jkappa or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jkappa and Activate Transcription J. Biol. Chem., April 25, 1997; 272(17): 11336 - 11343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Z. Bao and C. L. Cepko The Expression and Function of Notch Pathway Genes in the Developing Rat Eye J. Neurosci., February 15, 1997; 17(4): 1425 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Frade, P Bovolenta, J. Martinez-Morales, A Arribas, J. Barbas, and A Rodriguez-Tebar Control of early cell death by BDNF in the chick retina Development, January 9, 1997; 124(17): 3313 - 3320. [Abstract] [PDF]
|
|
|
|
|
|
C Neophytou, A. Vernallis, A Smith, and M. Raff Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development Development, January 6, 1997; 124(12): 2345 - 2354. [Abstract] [PDF]
|
|
|
|
|
|
Z. Ezzeddine, X Yang, T DeChiara, G Yancopoulos, and C. Cepko Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina Development, January 3, 1997; 124(5): 1055 - 1067. [Abstract] [PDF]
|
|
|
|
|
|
M. Alexiades and C. Cepko Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny Development, January 3, 1997; 124(6): 1119 - 1131. [Abstract] [PDF]
|
|
|
|
|
|
J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]
|
|
|
|
|
|
A. Jensen and V. Wallace Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina Development, January 1, 1997; 124(2): 363 - 371. [Abstract] [PDF]
|
|
|
|
|
|
X. Yang and C. L. Cepko Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells J. Neurosci., October 1, 1996; 16(19): 6089 - 6099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Larkin, K Holder, C Yost, E Giniger, and H Ruohola-Baker Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte Development, January 11, 1996; 122(11): 3639 - 3650. [Abstract] [PDF]
|
|
