|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 11 3745-3752, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
V. Jennings, J. de Celis, C. Delidakis, A. Preiss and S. Bray
The proteins encoded by Notch and the Enhancer of split complex are components of a cell-cell interaction mechanism which is important in many cell fate decisions throughout development. One such decision is the formation of the sensory organ precursor cell during the development of the peripheral nervous system in Drosophila. Cells acquire the potential to be neural through the expression of the proneural genes, and the Notch pathway is required to limit neural fate to a single cell from a proneural cluster. However, despite extensive analysis, the precise pathways linking the proneural with Notch and Enhancer of split gene functions remain obscure. For example, it has been suggested that achaete-scute complex proteins directly activate Enhancer of split genes leaving the action of Notch in the pathway unclear. Using monoclonal antibodies that recognise products of the Enhancer of split complex, we show that these proteins accumulate in the cells surrounding the developing sensory organ precursor cell and that their expression is dependent on the activity of Notch and does not directly correlate with expression of Achaete. We further clarify the pathway by showing that ubiquitous expression of an activated Notch receptor leads to widespread accumulation of Enhancer of split proteins even in the absence of achaete-scute complex proteins. Thus Enhancer of split protein expression in response to Notch activity does not require achaete-scute complex proteins.
This article has been cited by other articles:
|
|
 |
|
  C.-P. Hsu, P.-H. Lee, C.-W. Chang, and C.-T. Lee Constructing quantitative models from qualitative mutant phenotypes: preferences in selecting sensory organ precursors Bioinformatics, June 1, 2006; 22(11): 1375 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-T. Ong, H.-T. Cheng, L.-W. Chang, T. Ohtsuka, R. Kageyama, G. D. Stormo, and R. Kopan Target Selectivity of Vertebrate Notch Proteins: COLLABORATION BETWEEN DISCRETE DOMAINS AND CSL-BINDING SITE ARCHITECTURE DETERMINES ACTIVATION PROBABILITY J. Biol. Chem., February 24, 2006; 281(8): 5106 - 5119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Castro, S. Barolo, A. M. Bailey, and J. W. Posakony Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless Development, August 1, 2005; 132(15): 3333 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Escudero, S.-Y. Wei, W.-H. Chiu, J. Modolell, and J.-C. Hsu Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning Development, December 22, 2003; 130(25): 6305 - 6316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Culi, E Martin-Blanco, and J Modolell The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning Development, January 1, 2001; 128(2): 299 - 308. [Abstract] [PDF]
|
|
|
|
 |
|
 C. S. Wesley Notch and Wingless Regulate Expression of Cuticle Patterning Genes Mol. Cell. Biol., August 1, 1999; 19(8): 5743 - 5758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Jennings, D. M. Tyler, and S. J. Bray Target Specificities of Drosophila Enhancer of split Basic Helix-Loop-Helix Proteins Mol. Cell. Biol., July 1, 1999; 19(7): 4600 - 4610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C Mol. Cell. Biol., April 1, 1999; 19(4): 2853 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P zur Lage and A. Jarman Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors Development, January 6, 1999; 126(14): 3149 - 3157. [Abstract] [PDF]
|
|
|
|
|
|
P Ligoxygakis, S. Bray, Y Apidianakis, and C Delidakis Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila Development, January 5, 1999; 126(10): 2205 - 2214. [Abstract] [PDF]
|
|
|
|
|
|
S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Jones, G. May, L. Healy, J. Brown, G. Hoyne, S. Delassus, and T. Enver Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells Blood, September 1, 1998; 92(5): 1505 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Culí and J. Modolell Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling Genes & Dev., July 1, 1998; 12(13): 2036 - 2047. [Abstract] [Full Text]
|
|
|
|
|
|
T Klein and A. Arias Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development Development, January 8, 1998; 125(15): 2951 - 2962. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Alifragis, G. Poortinga, S. M. Parkhurst, and C. Delidakis A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system PNAS, November 25, 1997; 94(24): 13099 - 13104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Sotillos, F Roch, and S Campuzano The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs Development, January 12, 1997; 124(23): 4769 - 4779. [Abstract] [PDF]
|
|
|
|
|
|
X Sun and S Artavanis-Tsakonas Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Development, January 9, 1997; 124(17): 3439 - 3448. [Abstract] [PDF]
|
|
|
|
|
|
J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]
|
|
|
|
|
|
L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin Inhibition of granulocytic differentiation by mNotch1 PNAS, November 12, 1996; 93(23): 13014 - 13019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Chitnis and C Kintner Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos Development, July 1, 1996; 122(7): 2295 - 2301. [Abstract] [PDF]
|
|
|
|
|
|
M. Dokucu, S. Zipursky, and R. Cagan Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina Development, January 12, 1996; 122(12): 4139 - 4147. [Abstract] [PDF]
|
|
|
|
|
|
X Sun and S Artavanis-Tsakonas The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands Development, January 8, 1996; 122(8): 2465 - 2474. [Abstract] [PDF]
|
|
|
|
|
|
M Gho, M Lecourtois, G Geraud, J. Posakony, and F Schweisguth Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling Development, January 6, 1996; 122(6): 1673 - 1682. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]
|
|
