spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Curtiss, J.
Right arrow Articles by Heilig, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Curtiss, J.
Right arrow Articles by Heilig, J. S.

Development, Vol 121, Issue 11 3819-3828, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Establishment of Drosophila imaginal precursor cells is controlled by the Arrowhead gene

J Curtiss and JS Heilig
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309, USA.

Metamorphosis in Drosophila melanogaster requires synchronization of numerous developmental events that occur in isolated imaginal precursor tissues. The imaginal primordia are established during embryonic stages and are quiescent for much of larval life. The Arrowhead gene is necessary for establishment of proper numbers of cells within a subset of imaginal precursor tissues. Loss-of-function mutations in Arrowhead reduce the number of abdominal histoblasts and salivary gland imaginal ring cells before the proliferative stages of their development. The number of abdominal histoblasts in mutant animals is approximately half that of wild-type, as might result from failure of a single early division of these cells. A neomorphic Arrowhead allele results in the specific loss of the retinal precursors by the early third instar, before they have begun to differentiate. Since Arrowhead mutations affect only subsets of imaginal tissue, there must be distinctions in the developmental regulation of different imaginal precursors. Arrowhead may be part of a regulatory pathway responsible for establishing the proper number of abdominal histoblasts and salivary gland imaginal ring cells. The neomorphic Arrowhead allele, which may cause misexpression of the Arrowhead gene in the eye-antenna imaginal disc, interferes with the establishment or proliferation of retinal precursor cells.


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
A. Heyland and L. L. Moroz
Signaling mechanisms underlying metamorphic transitions in animals
Integr. Comp. Biol., December 1, 2006; 46(6): 743 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
P. Morcillo, C. Rosen, M. K. Baylies, and D. Dorsett
Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
Genes & Dev., October 15, 1997; 11(20): 2729 - 2740.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1995