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Development, Vol 121, Issue 12 3923-3933, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

Longitudinal organization of the anterior neural plate and neural tube

K Shimamura, DJ Hartigan, S Martinez, L Puelles and JL Rubenstein
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143-0984, USA.

Over the last century, several morphological models of forebrain organization have been proposed that hypothesize alternative topological solutions for the relationships of the histogenic primordia. Central to all of these models are their definitions of the longitudinal axis and the longitudinal organization of the neural plate and neural tube. To understand the longitudinal organization of the anterior brain, we have sought to identify molecular properties that are continuous along the entire longitudinal axis of the embryonic CNS. In this essay, we describe studies of the expression of several genes in the mouse between 7.5 (presomite stage) and 10.5 days post coitum (dpc) that provide evidence for the trajectory of the anterior-posterior axis and the longitudinal organization of the anterior CNS. Specifically, we report that the expression of noggin, sonic hedgehog and Nkx-2.2 define longitudinal columns of cells that are present along the entire CNS axis. Within the forebrain, the expression of these genes, as well as that of Nkx-2.1 and BF-1, are in distinct longitudinal regions in the neural plate and tube. We demonstrate that the earliest longitudinal axon pathways of the forebrain are spatially correlated with the longitudinal domain defined by Nkx-2.2. Finally, expression of the former genes, and Otx-1 and Emx-2, suggests that the cephalic neural plate is organized into molecularly distinct domains delimited by longitudinal and transverse borders; these results provide a foundation for defining the mechanisms that pattern the neural plate.
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M. Depew, J. Liu, J. Long, R Presley, J. Meneses, R. Pedersen, and J. Rubenstein
Dlx5 regulates regional development of the branchial arches and sensory capsules
Development, January 9, 1999; 126(17): 3831 - 3846.
[Abstract] [PDF]

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 DevelopmentHome page
L Sussel, O Marin, S Kimura, and J. Rubenstein
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
Development, January 8, 1999; 126(15): 3359 - 3370.
[Abstract] [PDF]

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 DevelopmentHome page
H. Etchevers, G Couly, C Vincent, and N. Le Douarin
Anterior cephalic neural crest is required for forebrain viability
Development, January 8, 1999; 126(16): 3533 - 3543.
[Abstract] [PDF]

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 DevelopmentHome page
T Theil, G Alvarez-Bolado, A Walter, and U Ruther
Gli3 is required for Emx gene expression during dorsal telencephalon development
Development, January 8, 1999; 126(16): 3561 - 3571.
[Abstract] [PDF]

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 DevelopmentHome page
D Arendt and K Nubler-Jung
Comparison of early nerve cord development in insects and vertebrates
Development, January 6, 1999; 126(11): 2309 - 2325.
[Abstract] [PDF]

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 DevelopmentHome page
R Tuttle, Y Nakagawa, J. Johnson, and D. O'Leary
Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient mice
Development, January 5, 1999; 126(9): 1903 - 1916.
[Abstract] [PDF]

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 DevelopmentHome page
K Hentges, K Thompson, and A Peterson
The flat-top gene is required for the expansion and regionalization of the telencephalic primordium
Development, January 4, 1999; 126(8): 1601 - 1609.
[Abstract] [PDF]

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 DevelopmentHome page
H Toresson, A Mata de Urquiza, C Fagerstrom, T Perlmann, and K Campbell
Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation
Development, January 3, 1999; 126(6): 1317 - 1326.
[Abstract] [PDF]

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 DevelopmentHome page
S Casarosa, C Fode, and F Guillemot
Mash1 regulates neurogenesis in the ventral telencephalon
Development, January 2, 1999; 126(3): 525 - 534.
[Abstract] [PDF]

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 J. Neurosci.Home page
D. W. Sretavan and K. Kruger
Randomized Retinal Ganglion Cell Axon Routing at the Optic Chiasm of GAP-43-Deficient Mice: Association with Midline Recrossing and Lack of Normal Ipsilateral Axon Turning
J. Neurosci., December 15, 1998; 18(24): 10502 - 10513.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. M. Pedersen, B. Finsen, J. E. Celis, and N. A. Jensen
Expression of a Novel Murine Phospholipase D Homolog Coincides with Late Neuronal Development in the Forebrain
J. Biol. Chem., November 20, 1998; 273(47): 31494 - 31504.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
K. J. Lee, M. Mendelsohn, and T. M. Jessell
Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
Genes & Dev., November 1, 1998; 12(21): 3394 - 3407.
[Abstract] [Full Text]

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 J. Neurosci.Home page
L. Yang, H. Zhang, G. Hu, H. Wang, C. Abate-Shen, and M. M. Shen
An Early Phase of Embryonic Dlx5 Expression Defines the Rostral Boundary of the Neural Plate
J. Neurosci., October 15, 1998; 18(20): 8322 - 8330.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
J. A. McMahon, S. Takada, L. B. Zimmerman, C.-M. Fan, R. M. Harland, and A. P. McMahon
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
Genes & Dev., May 15, 1998; 12(10): 1438 - 1452.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
S. Guazzi, M. L. Pintonello, A. Vigano, and E. Boncinelli
Regulatory Interactions between the Human HOXB1, HOXB2, and HOXB3 Proteins and the Upstream Sequence of the Otx2 Gene in Embryonal Carcinoma Cells
J. Biol. Chem., May 1, 1998; 273(18): 11092 - 11099.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
N Takuma, H. Sheng, Y Furuta, J. Ward, K Sharma, B. Hogan, S. Pfaff, H Westphal, S Kimura, and K. Mahon
Formation of Rathke's pouch requires dual induction from the diencephalon
Development, January 12, 1998; 125(23): 4835 - 4840.
[Abstract] [PDF]

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 DevelopmentHome page
J. Kohtz, D. Baker, G Corte, and G Fishell
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
Development, January 12, 1998; 125(24): 5079 - 5089.
[Abstract] [PDF]

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 DevelopmentHome page
K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
Development, January 11, 1998; 125(21): 4273 - 4282.
[Abstract] [PDF]

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 DevelopmentHome page
Q Ding, J Motoyama, S Gasca, R Mo, H Sasaki, J Rossant, and C. Hui
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
Development, January 7, 1998; 125(14): 2533 - 2543.
[Abstract] [PDF]

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 DevelopmentHome page
R Tuttle, J. Braisted, L. Richards, and D. O'Leary
Retinal axon guidance by region-specific cues in diencephalon
Development, January 3, 1998; 125(5): 791 - 801.
[Abstract] [PDF]

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 DevelopmentHome page
H Wada, H Saiga, N Satoh, and P. Holland
Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
Development, January 3, 1998; 125(6): 1113 - 1122.
[Abstract] [PDF]

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 CROBMHome page
K.M. Weiss, D.W. Stock, and Z. Zhao
Dynamic Interactions and the Evolutionary Genetics of Dental Patterning
Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 369 - 398.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
C. Neyt, M. Welch, A. Langston, J. Kohtz, and G. Fishell
A Short-Range Signal Restricts Cell Movement between Telencephalic Proliferative Zones
J. Neurosci., December 1, 1997; 17(23): 9194 - 9203.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
H. S. A. van Schaick, M. P. Smidt, A. C. Rovescalli, M. Luijten, A. A. M. van der Kleij, S. Asoh, C. A. Kozak, M. Nirenberg, and J. P. H. Burbach
Homeobox gene Prx3 expression in rodent brain and extraneural tissues
PNAS, November 25, 1997; 94(24): 12993 - 12998.
[Abstract] [Full Text] [PDF]


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